Cytolytic T cell granules. Isolation, structural, biochemical, and functional characterization
about
Medical immunology: a new journal for a new subspecialty.Perforin-low memory CD8+ cells are the predominant T cells in normal humans that synthesize the beta -chemokine macrophage inflammatory protein-1betaRecombinant human granzyme A binds to two putative HLA-associated proteins and cleaves one of themOn the mechanism of unidirectional killing in mixtures of two cytotoxic T lymphocytes. Unidirectional polarization of cytoplasmic organelles and the membrane-associated cytoskeleton in the effector cellNatural killer activity: early days, advances, and seminal observationsKilling of Microbes and Cancer by the Immune System with Three Mammalian Pore-Forming Killer ProteinsPurification and characterization of a T cell specific serine proteinase (TSP-1) from cloned cytolytic T lymphocytesThe MACPF/CDC family of pore-forming toxins.Early events in target-cell lysis by cytotoxic T cells.Cytotoxic T lymphocyte-induced killing in the absence of granzymes A and B is unique and distinct from both apoptosis and perforin-dependent lysis.Granzyme A and B-deficient killer lymphocytes are defective in eliciting DNA fragmentation but retain potent in vivo anti-tumor capacity.Enrichment and analysis of secretory lysosomes from lymphocyte populationsAnti-viral strategies of cytotoxic T lymphocytes are manifested through a variety of granule-bound pathways of apoptosis induction.Identification and sequencing of cDNA clones encoding the granule-associated serine proteases granzymes D, E, and F of cytolytic T lymphocytesSelf-protection of cytotoxic lymphocytes: a soluble form of homologous restriction factor in cytoplasmic granules.Molecular cloning of an inducible serine esterase gene from human cytotoxic lymphocytesCasein expression in cytotoxic T lymphocytes.Granules of cytolytic T-lymphocytes contain two serine esterases.Cognate peptides induce self-destruction of CD8+ cytolytic T lymphocytesStepwise maturation of lytic granules during differentiation and activation of human CD8+ T lymphocytes.Aberrant maturation of mutant perforin underlies the clinical diversity of hemophagocytic lymphohistiocytosis.Perforin evolved from a gene duplication of MPEG1, followed by a complex pattern of gene gain and loss within EuteleostomiFunctional assessment of perforin C2 domain mutations illustrates the critical role for calcium-dependent lipid binding in perforin cytotoxic functionPerforin: structure, function, and role in human immunopathology.High activity of N-alpha-benzyloxycarbonyl-L-lysine thiobenzyl ester serine esterase and cytolytic perforin in cloned cell lines is not demonstrable in in-vivo-induced cytotoxic effector cells.Functional channel formation associated with cytotoxic T-cell granules.Cloning of two genes that are specifically expressed in activated cytotoxic T lymphocytesMechanism of cytotoxicity of human large granular lymphocytes: relationship of the cytotoxic lymphocyte protein to the ninth component (C9) of human complement.Consensus nomenclature for CD8(+) T cell phenotypes in cancerGranzyme B-inhibitor serpina3n induces neuroprotection in vitro and in vivo.Phenotypic evolution of CTL B-lines in vitro.Perforin-2/Mpeg1 and other pore-forming proteins throughout evolutionPerforin-2 is essential for intracellular defense of parenchymal cells and phagocytes against pathogenic bacteria.The Thy-1-bearing cell of murine epidermis. A distinctive leukocyte perhaps related to natural killer cellsThe action of leucyl-leucine methyl ester on cytotoxic lymphocytes requires uptake by a novel dipeptide-specific facilitated transport system and dipeptidyl peptidase I-mediated conversion to membranolytic products.Properties of a purified pore-forming protein (perforin 1) isolated from H-2-restricted cytotoxic T cell granules.Calcium ion concentrations and DNA fragmentation in target cell destruction by murine cloned cytotoxic T lymphocytes.Serine esterase and hemolytic activity in human cloned cytotoxic T lymphocytes.Resistance of cytotoxic T lymphocytes to the lytic effects of their toxic granulesGranzyme B (GraB) autonomously crosses the cell membrane and perforin initiates apoptosis and GraB nuclear localization.
P2860
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P2860
Cytolytic T cell granules. Isolation, structural, biochemical, and functional characterization
description
1984 nî lūn-bûn
@nan
1984年の論文
@ja
1984年学术文章
@wuu
1984年学术文章
@zh-cn
1984年学术文章
@zh-hans
1984年学术文章
@zh-my
1984年学术文章
@zh-sg
1984年學術文章
@yue
1984年學術文章
@zh
1984年學術文章
@zh-hant
name
Cytolytic T cell granules. Iso ...... nd functional characterization
@ast
Cytolytic T cell granules. Iso ...... nd functional characterization
@en
type
label
Cytolytic T cell granules. Iso ...... nd functional characterization
@ast
Cytolytic T cell granules. Iso ...... nd functional characterization
@en
prefLabel
Cytolytic T cell granules. Iso ...... nd functional characterization
@ast
Cytolytic T cell granules. Iso ...... nd functional characterization
@en
P2860
P356
P1476
Cytolytic T cell granules. Iso ...... nd functional characterization
@en
P2093
E R Podack
P J Konigsberg
P2860
P304
P356
10.1084/JEM.160.3.695
P407
P577
1984-09-01T00:00:00Z