Chloroquine affects biosynthesis of Ia molecules by inhibiting dissociation of invariant (gamma) chains from alpha-beta dimers in B cells.
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Structure of the human Ia-associated invariant (gamma)-chain gene: identification of 5' sequences shared with major histocompatibility complex class II genesEndosomal aspartic proteinases are required for invariant-chain processingDecreased endosomal delivery of major histocompatibility complex class II-invariant chain complexes in dynamin-deficient cellsAntigen presentation to HLA class II-restricted measles virus-specific T-cell clones can occur in the absence of the invariant chain.Role for intracellular proteases in the processing and transport of class II HLA antigens.Why functional pre-erythrocytic and bloodstage malaria vaccines fail: a meta-analysis of fully protective immunizations and novel immunological model.Chloroquine inhibits Ca2+ permeable ion channels-mediated Ca2+ signaling in primary B lymphocytesMouse B lymphocyte specific endocytosis and recycling of MHC class II moleculesPrimary structure of the gene for the murine Ia antigen-associated invariant chains (Ii). An alternatively spliced exon encodes a cysteine-rich domain highly homologous to a repetitive sequence of thyroglobulinNew concepts in antimalarial use and mode of action in dermatology.Antimalarials in cutaneous lupus erythematosus: mechanisms of therapeutic benefit.The relationship between antigen concentration, antigen internalization, and antigenic complexes: modeling insights into antigen processing and presentationEnhanced binding of peptide antigen to purified class II major histocompatibility glycoproteins at acidic pH.Separation of subcellular compartments containing distinct functional forms of MHC class IIEfficient endosomal localization of major histocompatibility complex class II-invariant chain complexes requires multimerization of the invariant chain targeting sequence.The human invariant chain is the core protein of the human class II-associated proteoglycan.An endogenous processing pathway in vaccinia virus-infected cells for presentation of cytoplasmic antigens to class II-restricted T cellsAntigen processing by epidermal Langerhans cells correlates with the level of biosynthesis of major histocompatibility complex class II molecules and expression of invariant chainRelationship between invariant chain expression and major histocompatibility complex class II transport into early and late endocytic compartments.Inhibition of invariant chain (Ii)-calnexin interaction results in enhanced degradation of Ii but does not prevent the assembly of alpha beta Ii complexesA structural transition in class II major histocompatibility complex proteins at mildly acidic pH.The specific direct interaction of helper T cells and antigen-presenting B cells. II. Reorientation of the microtubule organizing center and reorganization of the membrane-associated cytoskeleton inside the bound helper T cells.Transport and intracellular distribution of MHC class II molecules and associated invariant chain in normal and antigen-processing mutant cell lines.The cell biology of antigen processing.Proteolysis of the class II-associated invariant chain generates a peptide binding site in intracellular HLA-DR molecules.How MHC class II molecules reach the endocytic pathway.Hydroxychloroquine in systemic lupus erythematosus and rheumatoid arthritis and its safety in pregnancy.Non-antigen-specific triggering signals for human cytotoxic T lymphocytes.Class II antigen processing compartments and the function of HLA-DM.The endogenous pathway of MHC class II antigen presentation.Intracellular transport and localization of major histocompatibility complex class II molecules and associated invariant chain.Presentation of Salmonella antigens by peritoneal cells of normal and Salmonella-infected mice.Accessory cell-T lymphocyte interactions. Antigen-dependent and -independent clustering.MHC class II presentation of endogenous tumor antigen by cellular vaccines depends on the endocytic pathway but not H2-M.Epitope-specific enhancement of antigen presentation by invariant chain.T cell stimulation by staphylococcal enterotoxins. Clonally variable response and requirement for major histocompatibility complex class II molecules on accessory or target cells.Major histocompatibility complex class II-dependent unfolding, transport, and degradation of endogenous proteins.Invariant chain distinguishes between the exogenous and endogenous antigen presentation pathways.The antiphospholipid syndrome and SLE: is there a clue in the link between complement and coagulation?
P2860
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P2860
Chloroquine affects biosynthesis of Ia molecules by inhibiting dissociation of invariant (gamma) chains from alpha-beta dimers in B cells.
description
1985 nî lūn-bûn
@nan
1985年の論文
@ja
1985年学术文章
@wuu
1985年学术文章
@zh-cn
1985年学术文章
@zh-hans
1985年学术文章
@zh-my
1985年学术文章
@zh-sg
1985年學術文章
@yue
1985年學術文章
@zh
1985年學術文章
@zh-hant
name
Chloroquine affects biosynthes ...... alpha-beta dimers in B cells.
@ast
Chloroquine affects biosynthes ...... alpha-beta dimers in B cells.
@en
type
label
Chloroquine affects biosynthes ...... alpha-beta dimers in B cells.
@ast
Chloroquine affects biosynthes ...... alpha-beta dimers in B cells.
@en
prefLabel
Chloroquine affects biosynthes ...... alpha-beta dimers in B cells.
@ast
Chloroquine affects biosynthes ...... alpha-beta dimers in B cells.
@en
P2860
P356
P1476
Chloroquine affects biosynthes ...... alpha-beta dimers in B cells.
@en
P2093
P2860
P304
P356
10.1084/JEM.162.4.1371
P407
P577
1985-10-01T00:00:00Z