Relationship between invariant chain expression and major histocompatibility complex class II transport into early and late endocytic compartments.
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Cell surface HLA-DR-invariant chain complexes are targeted to endosomes by rapid internalizationMajor histocompatibility complex class II-associated p41 invariant chain fragment is a strong inhibitor of lysosomal cathepsin LAn isoform of the Golgi t-SNARE, syntaxin 5, with an endoplasmic reticulum retrieval signalA role for acidic residues in di-leucine motif-based targeting to the endocytic pathwayEndosomal aspartic proteinases are required for invariant-chain processingEndosomal proteolysis of internalized proteinsPhagocytic antigen processing and effects of microbial products on antigen processing and T-cell responses.Mtv-1 superantigen trafficks independently of major histocompatibility complex class II directly to the B-cell surface by the exocytic pathway.Intracellular traffic to compartments for MHC class II peptide loading: signals for endosomal and polarized sorting.Proteolysis of major histocompatibility complex class II-associated invariant chain is regulated by the alternatively spliced gene product, p41.The cytoplasmic tail of invariant chain regulates endosome fusion and morphologyUncoating ATPase Hsc70 is recruited by invariant chain and controls the size of endocytic compartmentsExpression of endogenous peptide-major histocompatibility complex class II complexes derived from invariant chain-antigen fusion proteinsPhagocytic processing of antigens for presentation by class II major histocompatibility complex molecules.Human immunodeficiency virus type 1 endocytic trafficking through macrophage bridging conduits facilitates spread of infection.Parasite Manipulation of the Invariant Chain and the Peptide Editor H2-DM Affects Major Histocompatibility Complex Class II Antigen Presentation during Toxoplasma gondii Infection.In the absence of the invariant chain, HLA-DR molecules display a distinct array of peptides which is influenced by the presence or absence of HLA-DMEfficient endosomal localization of major histocompatibility complex class II-invariant chain complexes requires multimerization of the invariant chain targeting sequence.Isoforms of the invariant chain regulate transport of MHC class II molecules to antigen processing compartmentsEnhanced antigen presentation in the absence of the invariant chain endosomal localization signal.The CLIP region of invariant chain plays a critical role in regulating major histocompatibility complex class II folding, transport, and peptide occupancyInhibition of invariant chain (Ii)-calnexin interaction results in enhanced degradation of Ii but does not prevent the assembly of alpha beta Ii complexesEvidence that binding site occupancy is necessary and sufficient for effective major histocompatibility complex (MHC) class II transport through the secretory pathway redefines the primary function of class II-associated invariant chain peptides (CLInvariant chain controls H2-M proteolysis in mouse splenocytes and dendritic cellsRelated leucine-based cytoplasmic targeting signals in invariant chain and major histocompatibility complex class II molecules control endocytic presentation of distinct determinants in a single protein.Degradation of mouse invariant chain: roles of cathepsins S and D and the influence of major histocompatibility complex polymorphismA lysosomal targeting signal in the cytoplasmic tail of the beta chain directs HLA-DM to MHC class II compartments.Sorting signals in the MHC class II invariant chain cytoplasmic tail and transmembrane region determine trafficking to an endocytic processing compartment.Presentation of phagocytosed antigens by MHC class I and II.Transport and intracellular distribution of MHC class II molecules and associated invariant chain in normal and antigen-processing mutant cell lines.Functionality of major histocompatibility complex class II molecules in mice doubly deficient for invariant chain and H-2M complexesEarly endosomes are required for major histocompatiblity complex class II transport to peptide-loading compartments.Exposing the Specific Roles of the Invariant Chain Isoforms in Shaping the MHC Class II Peptidome.Association with BiP and aggregation of class II MHC molecules synthesized in the absence of invariant chain.Re-Directing CD4(+) T Cell Responses with the Flanking Residues of MHC Class II-Bound Peptides: The Core is Not Enough.TAPBPR: a new player in the MHC class I presentation pathway.Invariant Chain Complexes and Clusters as Platforms for MIF Signaling.The biochemistry and cell biology of antigen presentation by MHC class I and class II molecules. Implications for development of combination vaccines.Physiological functions of endosomal proteolysis.An N-terminal double-arginine motif maintains type II membrane proteins in the endoplasmic reticulum
P2860
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P2860
Relationship between invariant chain expression and major histocompatibility complex class II transport into early and late endocytic compartments.
description
1993 nî lūn-bûn
@nan
1993年の論文
@ja
1993年学术文章
@wuu
1993年学术文章
@zh-cn
1993年学术文章
@zh-hans
1993年学术文章
@zh-my
1993年学术文章
@zh-sg
1993年學術文章
@yue
1993年學術文章
@zh
1993年學術文章
@zh-hant
name
Relationship between invariant ...... d late endocytic compartments.
@ast
Relationship between invariant ...... d late endocytic compartments.
@en
type
label
Relationship between invariant ...... d late endocytic compartments.
@ast
Relationship between invariant ...... d late endocytic compartments.
@en
prefLabel
Relationship between invariant ...... d late endocytic compartments.
@ast
Relationship between invariant ...... d late endocytic compartments.
@en
P2093
P2860
P356
P1476
Relationship between invariant ...... nd late endocytic compartments
@en
P2093
P2860
P304
P356
10.1084/JEM.177.3.583
P407
P577
1993-03-01T00:00:00Z