A single germline VH gene segment of normal A/J mice encodes autoantibodies characteristic of systemic lupus erythematosus
about
Natural antibody and complement mediate neutralization of influenza virus in the absence of prior immunityRole of Natural Autoantibodies and Natural IgM Anti-Leucocyte Autoantibodies in Health and DiseaseTwo murine natural polyreactive autoantibodies are encoded by nonmutated germ-line genesSpecific recognition of a dsDNA sequence motif by an immunoglobulin VH homodimer.The BALB/c mouse B-cell response to pigeon cytochrome c initiates as a heteroclitic response specific for the self antigen mouse cytochrome c.Redemption of autoantibodies on anergic B cells by variable-region glycosylation and mutation away from self-reactivity.Population and family studies of three disease-related polymorphic genes in systemic lupus erythematosus.Molecular basis of an autoantibody-associated restriction fragment length polymorphism that confers susceptibility to autoimmune diseasesMolecular characterization of a somatically mutated anti-DNA antibody bearing two systemic lupus erythematosus-related idiotypesImmunochemistry of DNA.Human autoantibody recognition of DNAExpression in systemic lupus erythematosus of an idiotype common to DNA-binding and nonbinding monoclonal antibodies produced by normal human lymphoid cells.Epstein-Barr virus-induced autoimmune responses. II. Immunoglobulin G autoantibodies to mimicking and nonmimicking epitopes. Presence in autoimmune diseaseCellular competition independent of BAFF/B lymphocyte stimulator results in low frequency of an autoreactive clonotype in mature polyclonal B cell compartmentsAutoantibody activity and V gene usage by B-cell malignancies.Genetic regulation of CD5+ B cells in autoimmune disease and in chronic lymphocytic leukemia.VH-gene representation in autoantibodies reflects the normal human B-cell repertoire.Activation of clones producing self-reactive antibodies by foreign antigen and antiidiotype antibody carrying the internal image of the antigenAntibodies elicited by pneumococcal antigens bear an anti-DNA--associated idiotype.Ontogeny of the immune system and the invisible frontier to immune regulation.Dock8 mutations cripple B cell immunological synapses, germinal centers and long-lived antibody production.A novel class of anti-DNA antibodies identified in BALB/c mice.Characterization of somatically mutated S107 VH11-encoded anti-DNA autoantibodies derived from autoimmune (NZB x NZW)F1 mice.Structure of the VH and VL segments of polyreactive and monoreactive human natural antibodies to HIV-1 and Escherichia coli beta-galactosidaseClonal analysis of a human antibody response. Quantitation of precursors of antibody-producing cells and generation and characterization of monoclonal IgM, IgG, and IgA to rabies virusA conserved human germline V kappa gene directly encodes rheumatoid factor light chains.Autoantibodies of various specificities encoded by genes from the VH J558 family bind to foreign antigens and share idiotopes of antibodies specific for self and foreign antigens.Isolation and characterization of a light chain variable region gene for human rheumatoid factorsRandom mutagenesis of two complementarity determining region amino acids yields an unexpectedly high frequency of antibodies with increased affinity for both cognate antigen and autoantigen.VH genes of human autoantibodies.Monoclonal IgM rheumatoid factors bind IgG at a discontinuous epitope comprised of amino acid loops from heavy-chain constant-region domains 2 and 3.Genetic analysis of the variable region genes encoding a monospecific human natural anti-DNA antibody.Self tolerance in the B-cell repertoire.Population dynamics of natural antibodies in normal and autoimmune individuals.Pathogenic anti-DNA antibodies in SLE: idiotypic families and genetic origins.Elucidating the pathogenesis of autoimmune disease: recent advances at the molecular level and relevance to oral mucosal disease.Autoantibodies and antibacterial antibodies: from both sides now.The role of somatic hypermutation in the generation of pathogenic antibodies in SLE.Natural autoantibodies and associated B cells in immunity and autoimmunity.The molecular origin of anti-DNA antibodies.
P2860
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P2860
A single germline VH gene segment of normal A/J mice encodes autoantibodies characteristic of systemic lupus erythematosus
description
1986 nî lūn-bûn
@nan
1986年の論文
@ja
1986年学术文章
@wuu
1986年学术文章
@zh-cn
1986年学术文章
@zh-hans
1986年学术文章
@zh-my
1986年学术文章
@zh-sg
1986年學術文章
@yue
1986年學術文章
@zh
1986年學術文章
@zh-hant
name
A single germline VH gene segm ...... f systemic lupus erythematosus
@ast
A single germline VH gene segm ...... f systemic lupus erythematosus
@en
type
label
A single germline VH gene segm ...... f systemic lupus erythematosus
@ast
A single germline VH gene segm ...... f systemic lupus erythematosus
@en
prefLabel
A single germline VH gene segm ...... f systemic lupus erythematosus
@ast
A single germline VH gene segm ...... f systemic lupus erythematosus
@en
P2093
P2860
P356
P1476
A single germline VH gene segm ...... f systemic lupus erythematosus
@en
P2093
B D Stollar
J André-Schwartz
L Breitman
L J Wysocki
R S Schwartz
Y Naparstek
P2860
P304
P356
10.1084/JEM.164.2.614
P407
P577
1986-08-01T00:00:00Z