A conserved human germline V kappa gene directly encodes rheumatoid factor light chains.
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Autoantibody-associated kappa light chain variable region gene expressed in chronic lymphocytic leukemia with little or no somatic mutation. Implications for etiology and immunotherapyRheumatoid factors isolated from patients with autoimmune disorders are derived from germline genes distinct from those encoding the Wa, Po, and Bla cross-reactive idiotypes.Molecular mimicry between bacterial and self antigen in a patient with systemic lupus erythematosus.Human combinatorial antibody libraries to hepatitis B surface antigen.Cloning of a human autoimmune response: preparation and sequencing of a human anti-thyroglobulin autoantibody using a combinatorial approach.Physical map of the 3' region of the human immunoglobulin heavy chain locus: clustering of autoantibody-related variable segments in one haplotypeIdiotypes and anti-idiotypes: what are they trying to tell us?Reaction of rheumatoid factors with IgG3 monoclonal anti-Rh(D) antibodies: more frequent reactivity to a monoclonal antibody of the Gm allotype G3m(5) in rheumatoid patients negative for G3m(5).Somatic hypermutations confer rheumatoid factor activity in hepatitis C virus-associated mixed cryoglobulinemiaPossible deletion of a developmentally regulated heavy-chain variable region gene in autoimmune diseases.A novel upstream element compensates for an ineffectual octamer motif in an immunoglobulin V kappa promoter.Evidence of antigen receptor-influenced oligoclonal B lymphocyte expansion in the synovium of a patient with longstanding rheumatoid arthritis.Evidence that the V kappa III gene usage is nonstochastic in both adult and newborn peripheral B cells and that peripheral CD5+ adult B cells are oligoclonal.The complete nucleotide sequences of the heavy chain variable regions of six monospecific rheumatoid factors derived from Epstein-Barr virus-transformed B cells isolated from the synovial tissue of patients with rheumatoid arthritis. Further evidencRelationship of the CD5 B cell to human tonsillar lymphocytes that express autoantibody-associated cross-reactive idiotypesDevelopmentally restricted immunoglobulin heavy chain variable region gene expressed at high frequency in chronic lymphocytic leukemia.Nucleotidic sequence analysis of the variable domains of four human monoclonal IgM with an antibody activity to myelin-associated glycoprotein.Variable region sequences of a protective human monoclonal antibody specific for the Haemophilus influenzae type b capsular polysaccharideIdiotypic and subgroup analysis of human monoclonal rheumatoid factors. Implications for structural and genetic basis of autoantibodies in humans.High-frequency expression of a conserved kappa light-chain variable-region gene in chronic lymphocytic leukemia.B cell receptor light chain repertoires show signs of selection with differences between groups of healthy individuals and SLE patients.Immunoglobulin V gene expression in CD5 B-cell malignancies.Genetic regulation of CD5+ B cells in autoimmune disease and in chronic lymphocytic leukemia.Specificity and idiotope expression of IgM produced by CD5+ and CD5- cord blood B-cell clones.Rheumatoid factor V genes from patients with rheumatoid arthritis are diverse and show evidence of an antigen-driven response.Characterization of the cDNA of a broadly reactive neutralizing human anti-gp120 monoclonal antibody.Nucleotide sequence analysis of rheumatoid factors and polyreactive antibodies derived from patients with rheumatoid arthritis reveals diverse use of VH and VL gene segments and extensive variability in CDR-3.Somatic mutation and CDR3 lengths of immunoglobulin kappa light chains expressed in patients with rheumatoid arthritis and in normal individualsCD5-positive B-cell malignancies frequently express cross-reactive idiotypes associated with IgM autoantibodiesA transgenic mouse that expresses a diversity of human sequence heavy and light chain immunoglobulinsControl of autoantibody affinity by selection against amino acid replacements in the complementarity-determining regionsThe antigen-binding domain of a human IgG-anti-F(ab')2 autoantibody.Evidence for somatic selection of natural autoantibodies.Complete sequence of the genes encoding the VH and VL regions of low- and high-affinity monoclonal IgM and IgA1 rheumatoid factors produced by CD5+ B cells from a rheumatoid arthritis patient.Uniform high frequency expression of autoantibody-associated crossreactive idiotypes in the primary B cell follicles of human fetal spleen.Isolation and characterization of a light chain variable region gene for human rheumatoid factorsMonoreactive high affinity and polyreactive low affinity rheumatoid factors are produced by CD5+ B cells from patients with rheumatoid arthritis.Expression of a public idiotype by human monoclonal IgM directed to myelin-associated glycoprotein and characterization of the variability subgroup of their heavy and light chains.Cloning and characterisation of TPO autoantibodies using combinatorial phage display libraries.Malignant CD5 B cells--biased immunoglobulin variable gene usage and autoantibody production.
P2860
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P2860
A conserved human germline V kappa gene directly encodes rheumatoid factor light chains.
description
1986 nî lūn-bûn
@nan
1986年の論文
@ja
1986年学术文章
@wuu
1986年学术文章
@zh-cn
1986年学术文章
@zh-hans
1986年学术文章
@zh-my
1986年学术文章
@zh-sg
1986年學術文章
@yue
1986年學術文章
@zh
1986年學術文章
@zh-hant
name
A conserved human germline V kappa gene directly encodes rheumatoid factor light chains.
@ast
A conserved human germline V kappa gene directly encodes rheumatoid factor light chains.
@en
type
label
A conserved human germline V kappa gene directly encodes rheumatoid factor light chains.
@ast
A conserved human germline V kappa gene directly encodes rheumatoid factor light chains.
@en
prefLabel
A conserved human germline V kappa gene directly encodes rheumatoid factor light chains.
@ast
A conserved human germline V kappa gene directly encodes rheumatoid factor light chains.
@en
P2093
P2860
P356
P1476
A conserved human germline V kappa gene directly encodes rheumatoid factor light chains.
@en
P2093
P2860
P304
P356
10.1084/JEM.164.6.2119
P407
P577
1986-12-01T00:00:00Z