Leukemia-Associated Cohesin Mutants Dominantly Enforce Stem Cell Programs and Impair Human Hematopoietic Progenitor Differentiation.
about
Molecular landscape of acute myeloid leukemia in younger adults and its clinical relevanceEmerging concepts of epigenetic dysregulation in hematological malignanciesEpigenetics in Cancer: A Hematological PerspectiveComprehensive mutational profiling of core binding factor acute myeloid leukemia.The genetics of myelodysplastic syndrome: from clonal haematopoiesis to secondary leukaemiaThe three-dimensional cancer genome.HDAC8 Inhibition Blocks SMC3 Deacetylation and Delays Cell Cycle Progression without Affecting Cohesin-dependent Transcription in MCF7 Cancer Cells.ChREBP promotes the differentiation of leukemia-initiating cells to inhibit leukemogenesis through the TXNIP/RUNX1 pathways.DNA methylation heterogeneity defines a disease spectrum in Ewing sarcoma.The role of mutations in the cohesin complex in acute myeloid leukemia.Cohesin mutations in human cancerAdvancing haematopoietic stem and progenitor cell biology through single-cell profiling.Clinical Implications of Genetic Mutations in Myelodysplastic Syndrome.ASXL1 interacts with the cohesin complex to maintain chromatid separation and gene expression for normal hematopoiesis.MLL-AF9 and MLL-AF4 oncofusion proteins bind a distinct enhancer repertoire and target the RUNX1 program in 11q23 acute myeloid leukemia.Cohesin Mutations in Myeloid Malignancies.Epigenetics and Cancer Stem Cells: Unleashing, Hijacking, and Restricting Cellular Plasticity.The cohesin subunit Rad21 is a negative regulator of hematopoietic self-renewal through epigenetic repression of Hoxa7 and Hoxa9.Synthetic lethality between the cohesin subunits STAG1 and STAG2 in diverse cancer contexts.Integrating Enhancer Mechanisms to Establish a Hierarchical Blood Development Program.GATA Factor-Dependent Positive-Feedback Circuit in Acute Myeloid Leukemia Cells.Cohesin complex is a major player on the stage of leukemogenesis.Multiplexed genetic engineering of human hematopoietic stem and progenitor cells using CRISPR/Cas9 and AAV6.A DNA Contact Map for the Mouse Runx1 Gene Identifies Novel Haematopoietic EnhancersThe Cohesin Complex Is Necessary for Epidermal Progenitor Cell Function through Maintenance of Self-Renewal Genes.Preleukemic Hematopoietic Stem Cells in Human Acute Myeloid Leukemia.Cohesin mutations: contributors to myeloid malignancies.Down-syndrome-like acute megakaryoblastic leukemia in a patient with Cornelia de Lange syndrome.HDAC8 regulates long-term hematopoietic stem-cell maintenance under stress by modulating p53 activity.Multiplex CRISPR/Cas9-Based Genome Editing in Human Hematopoietic Stem Cells Models Clonal Hematopoiesis and Myeloid Neoplasia.Prognostic impacts and dynamic changes of cohesin complex gene mutations in de novo acute myeloid leukemia.Enhancer dysfunction in leukemia.Chromatin Accessibility Landscape of Cutaneous T Cell Lymphoma and Dynamic Response to HDAC Inhibitors.Therapeutic targeting of leukemic stem cells in acute myeloid leukemia - the biological background for possible strategies.
P2860
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P2860
Leukemia-Associated Cohesin Mutants Dominantly Enforce Stem Cell Programs and Impair Human Hematopoietic Progenitor Differentiation.
description
2015 nî lūn-bûn
@nan
2015年の論文
@ja
2015年学术文章
@wuu
2015年学术文章
@zh-cn
2015年学术文章
@zh-hans
2015年学术文章
@zh-my
2015年学术文章
@zh-sg
2015年學術文章
@yue
2015年學術文章
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2015年學術文章
@zh-hant
name
Leukemia-Associated Cohesin Mu ...... ic Progenitor Differentiation.
@ast
Leukemia-Associated Cohesin Mu ...... ic Progenitor Differentiation.
@en
type
label
Leukemia-Associated Cohesin Mu ...... ic Progenitor Differentiation.
@ast
Leukemia-Associated Cohesin Mu ...... ic Progenitor Differentiation.
@en
prefLabel
Leukemia-Associated Cohesin Mu ...... ic Progenitor Differentiation.
@ast
Leukemia-Associated Cohesin Mu ...... ic Progenitor Differentiation.
@en
P2093
P2860
P1433
P1476
Leukemia-Associated Cohesin Mu ...... ic Progenitor Differentiation.
@en
P2093
Claire Mazumdar
Daniel Thomas
Feifei Zhao
Howard Y Chang
Jason D Buenrostro
Julie L Koenig
M Ryan Corces
Ravindra Majeti
Seethu Xavy
P2860
P304
P356
10.1016/J.STEM.2015.09.017
P407
P577
2015-10-20T00:00:00Z