Selective positive modulator of calcium-activated potassium channels exerts beneficial effects in a mouse model of spinocerebellar ataxia type 2 - Wikidata - wikimedia - TriplyDB

Selective positive modulator of calcium-activated potassium channels exerts beneficial effects in a mouse model of spinocerebellar ataxia type 2

Selective positive modulator of calcium-activated potassium channels exerts beneficial effects in a mouse model of spinocerebellar ataxia type 2

http://www.wikidata.org/entity/Q36354944

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Precision medicine in spinocerebellar ataxias: treatment based on common mechanisms of disease Integration of modeling with experimental and clinical findings synthesizes and refines the central role of inositol 1,4,5-trisphosphate receptor 1 in spinocerebellar ataxia The riluzole derivative 2-amino-6-trifluoromethylthio-benzothiazole (SKA-19), a mixed KCa2 activator and NaV blocker, is a potent novel anticonvulsant.Unstructured to structured transition of an intrinsically disordered protein peptide in coupling Ca2+-sensing and SK channel activation Motor Dysfunctions and Neuropathology in Mouse Models of Spinocerebellar Ataxia Type 2: A Comprehensive Review Pharmacological gating modulation of small- and intermediate-conductance Ca(2+)-activated K(+) channels (KCa2.x and KCa3.1)Alterations in cerebellar physiology are associated with a stiff-legged gait in Atcay(ji-hes) mice A positive feedback loop linking enhanced mGluR function and basal calcium in spinocerebellar ataxia type 2 New positive Ca2+-activated K+ channel gating modulators with selectivity for KCa3.1.Physiologic changes associated with cerebellar dystonia.Computational neurobiology is a useful tool in translational neurology: the example of ataxia NeuroGeM, a knowledgebase of genetic modifiers in neurodegenerative diseases Targeting the Small- and Intermediate-Conductance Ca-Activated Potassium Channels: The Drug-Binding Pocket at the Channel/Calmodulin Interface The role for alterations in neuronal activity in the pathogenesis of polyglutamine repeat disorders.Selective phosphorylation modulates the PIP2 sensitivity of the CaM-SK channel complex Differential cerebellar GABAA receptor expression in mice with mutations in CaV2.1 (P/Q-type) calcium channels.Molecular overlap in the regulation of SK channels by small molecules and phosphoinositides Calcium signaling, excitability, and synaptic plasticity defects in a mouse model of Alzheimer's disease Mitochondrial small conductance SK2 channels prevent glutamate-induced oxytosis and mitochondrial dysfunction.In vivo analysis of cerebellar Purkinje cell activity in SCA2 transgenic mouse model.4-aminopyridine reverses ataxia and cerebellar firing deficiency in a mouse model of spinocerebellar ataxia type 6.The therapeutic potential of small-conductance KCa2 channels in neurodegenerative and psychiatric diseases Consensus paper: pathological mechanisms underlying neurodegeneration in spinocerebellar ataxias.Endothelial small-conductance and intermediate-conductance KCa channels: an update on their pharmacology and usefulness as cardiovascular targets.Cellular and circuit mechanisms underlying spinocerebellar ataxias.Translating cerebellar Purkinje neuron physiology to progress in dominantly inherited ataxia.IP3 receptor mutations and brain diseases in human and rodents.Downregulation of Purkinje Cell Activity by Modulators of Small Conductance Calcium-Activated Potassium Channels In Rat Cerebellum.Neuronal Atrophy Early in Degenerative Ataxia Is a Compensatory Mechanism to Regulate Membrane Excitability.Structural insights into the potency of SK channel positive modulators.Polyglutamine spinocerebellar ataxias - from genes to potential treatments.Transient cerebellar alterations during development prior to obvious motor phenotype in a mouse model of spinocerebellar ataxia type 6.Ion channel dysfunction in cerebellar ataxia.Potassium channel dysfunction underlies Purkinje neuron spiking abnormalities in spinocerebellar ataxia type 2.Targeting potassium channels to treat cerebellar ataxia.Dendritic potassium channel dysfunction may contribute to dendrite degeneration in spinocerebellar ataxia type 1.A V-to-F substitution in SK2 channels causes Ca2+ hypersensitivity and improves locomotion in a C. elegans ALS model.Altered synaptic and firing properties of cerebellar Purkinje cells in a mouse model of ARSACS

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P2860

Selective positive modulator of calcium-activated potassium channels exerts beneficial effects in a mouse model of spinocerebellar ataxia type 2

http://www.wikidata.org/entity/Q36354944

description

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2012年学术文章

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name

Selective positive modulator o ...... spinocerebellar ataxia type 2

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Selective positive modulator o ...... spinocerebellar ataxia type 2

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Selective positive modulator o ...... spinocerebellar ataxia type 2

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J.CHEMBIOL.2012.07.013

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Chemistry and Biology

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Selective positive modulator o ...... spinocerebellar ataxia type 2

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Adebimpe W Kasumu

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Birgitte L Eriksen

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Charlotte Hougaard

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Dasha Vorontsova

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Dorte Strøbæk

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Frederik Rode

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Ilya Bezprozvanny

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Jean Marc Sabatier

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Lars Christian B Rønn

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Palle Christophersen

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P2860

Nuclear localization or inclusion body formation of ataxin-2 are not necessary for SCA2 pathogenesis in mouse or human

Electrophysiological properties of in vitro Purkinje cell somata in mammalian cerebellar slices

Selective positive modulation of the SK3 and SK2 subtypes of small conductance Ca2+-activated K+ channels

Small conductance Ca2+-activated K+ channels modulate synaptic plasticity and memory encoding

Small-conductance Ca2+-activated K+ channels: form and function

Ca(2+)-activated K+ channels: molecular determinants and function of the SK family

Activation of human IK and SK Ca2+ -activated K+ channels by NS309 (6,7-dichloro-1H-indole-2,3-dione 3-oxime)

SK2 channel expression and function in cerebellar Purkinje cells

Decreases in the precision of Purkinje cell pacemaking cause cerebellar dysfunction and ataxia

Trinucleotide Repeat Disorders

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1340-1353

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10.1016/J.CHEMBIOL.2012.07.013

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10

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19

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