Chronic overexpression of PNPLA3I148M in mouse liver causes hepatic steatosis. - Wikidata - wikimedia - TriplyDB

Chronic overexpression of PNPLA3I148M in mouse liver causes hepatic steatosis.

Chronic overexpression of PNPLA3I148M in mouse liver causes hepatic steatosis.

http://www.wikidata.org/entity/Q36357941

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PNPLA3 mediates hepatocyte triacylglycerol remodeling Composite prognostic models across the non-alcoholic fatty liver disease spectrum: Clinical application in developing countries Non-alcoholic fatty liver disease and type 2 diabetes mellitus: the liver disease of our age?Pediatric fatty liver disease: role of ethnicity and genetics How Useful Are Monogenic Rodent Models for the Study of Human Non-Alcoholic Fatty Liver Disease?Nonalcoholic Fatty Liver Disease: Pathophysiology and Management.Omic studies reveal the pathogenic lipid droplet proteins in non-alcoholic fatty liver disease.Pediatric non-alcoholic fatty liver disease: New insights and future directions Molecular mechanisms and new treatment strategies for non-alcoholic steatohepatitis (NASH)The Association between Pediatric NAFLD and Common Genetic Variants.Mechanisms of Liver Injury in Non-Alcoholic Steatohepatitis Exome-wide association study identifies a TM6SF2 variant that confers susceptibility to nonalcoholic fatty liver disease.Inactivation of Tm6sf2, a Gene Defective in Fatty Liver Disease, Impairs Lipidation but Not Secretion of Very Low Density Lipoproteins.Pnpla3I148M knockin mice accumulate PNPLA3 on lipid droplets and develop hepatic steatosis PNPLA3 I148M variant in nonalcoholic fatty liver disease: demographic and ethnic characteristics and the role of the variant in nonalcoholic fatty liver fibrosis Identification of eQTLs for hepatic Xbp1s and Socs3 gene expression in mice fed a high-fat, high-caloric diet.Physiology and pathophysiology of liver lipid metabolism.PNPLA3 genetic variation in alcoholic steatosis and liver disease progression.DAG tales: the multiple faces of diacylglycerol--stereochemistry, metabolism, and signaling Oxidized metabolites of linoleic acid as biomarkers of liver injury in nonalcoholic steatohepatitis.Role of patatin-like phospholipase domain-containing 3 on lipid-induced hepatic steatosis and insulin resistance in rats Kcne2 deletion causes early-onset nonalcoholic fatty liver disease via iron deficiency anemia Biochemistry and pathophysiology of intravascular and intracellular lipolysis.The association between hepatic fat content and liver injury in obese children and adolescents: effects of ethnicity, insulin resistance, and common gene variants Mechanisms of hepatic triglyceride accumulation in non-alcoholic fatty liver disease.Overexpression of variant PNPLA3 gene at I148M position causes malignant transformation of hepatocytes via IL-6-JAK2/STAT3 pathway in low dose free fatty acid exposure: a laboratory investigation in vitro and in vivo.Diversity and population-genetic properties of copy number variations and multicopy genes in cattle.Functions of autophagy in normal and diseased liver.Functional validation of GWAS gene candidates for abnormal liver function during zebrafish liver development Interactions of a PPARGC1A Variant and a PNPLA3 Variant Affect Nonalcoholic Steatohepatitis in Severely Obese Taiwanese Patients.PNPLA3 I148M polymorphism and progressive liver disease.Genetic architecture of human fibrotic diseases: disease risk and disease progression.Altered gene expression patterns in muscle ring finger 1 null mice during denervation- and dexamethasone-induced muscle atrophy.Transcriptional regulation of PNPLA3 and its impact on susceptibility to nonalcoholic fatty liver Disease (NAFLD) in humans.The PNPLA3 Ile148Met interacts with overweight and dietary intakes on fasting triglyceride levels Serum TAG analysis differentiates between genetic and obesity-associated NAFLD Expression of SREBP-1c Requires SREBP-2-mediated Generation of a Sterol Ligand for LXR in Livers of Mice.Lipoprotein metabolism, dyslipidemia, and nonalcoholic fatty liver disease.Balancing the fat: lipid droplets and human disease.Non-alcoholic steatohepatitis: pathogenesis and novel therapeutic approaches.

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P2860

Chronic overexpression of PNPLA3I148M in mouse liver causes hepatic steatosis.

http://www.wikidata.org/entity/Q36357941

description

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2012年の論文

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2012年学术文章

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2012年学术文章

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2012年学术文章

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2012年学术文章

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2012年學術文章

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2012年學術文章

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2012年學術文章

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name

Chronic overexpression of PNPLA3I148M in mouse liver causes hepatic steatosis.

@ast

Chronic overexpression of PNPLA3I148M in mouse liver causes hepatic steatosis.

@en

type

label

Chronic overexpression of PNPLA3I148M in mouse liver causes hepatic steatosis.

@ast

Chronic overexpression of PNPLA3I148M in mouse liver causes hepatic steatosis.

@en

prefLabel

Chronic overexpression of PNPLA3I148M in mouse liver causes hepatic steatosis.

@ast

Chronic overexpression of PNPLA3I148M in mouse liver causes hepatic steatosis.

@en

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Journal of Clinical Investigation

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Chronic overexpression of PNPLA3I148M in mouse liver causes hepatic steatosis

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H Alex Brown

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Helen H Hobbs

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Jonathan C Cohen

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Jose Castro-Perez

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Pavlina T Ivanova

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Thomas Roddy

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Yongcheng Huang

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P2860

Identification, cloning, expression, and purification of three novel human calcium-independent phospholipase A2 family members possessing triacylglycerol lipase and acylglycerol transacylase activities

Expression of a novel human apolipoprotein (apoC-IV) causes hypertriglyceridemia in transgenic mice

Triacsin C blocks de novo synthesis of glycerolipids and cholesterol esters but not recycling of fatty acid into phospholipid: evidence for functionally separate pools of acyl-CoA

Identification of a gene encoding MGAT1, a monoacylglycerol acyltransferase.

Overexpression of Insig-1 in the livers of transgenic mice inhibits SREBP processing and reduces insulin-stimulated lipogenesis

SIRT4 regulates fatty acid oxidation and mitochondrial gene expression in liver and muscle cells

A RAPID METHOD OF TOTAL LIPID EXTRACTION AND PURIFICATION

A simple method for the isolation and purification of total lipides from animal tissues

The crystal structure, mutagenesis, and activity studies reveal that patatin is a lipid acyl hydrolase with a Ser-Asp catalytic dyad

Nonalcoholic steatohepatitis: Mayo Clinic experiences with a hitherto unnamed disease

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