Mitochondrial medicine: pharmacological targeting of mitochondria in disease
about
Combinatorial drug design targeting multiple cancer signaling networks controlled by mitochondrial Hsp90Paralog Specific Hsp90 Inhibitors - A Brief History and a Bright FutureMitochondria as a target in treatmentMitochondria and reactive oxygen species: physiology and pathophysiologyAsiatic acid, a pentacyclic triterpene in Centella asiatica, attenuates glutamate-induced cognitive deficits in mice and apoptosis in SH-SY5Y cells.Mitochondrial superoxide dismutase SOD2, but not cytosolic SOD1, plays a critical role in protection against glutamate-induced oxidative stress and cell death in HT22 neuronal cellsTargeted delivery of radioprotective agents to mitochondriaPotential therapeutic benefits of strategies directed to mitochondria.Mitochondrial dysfunction in retinal diseasesDanthron triggers ROS and mitochondria-mediated apoptotic death in C6 rat glioma cells through caspase cascades, apoptosis-inducing factor and endonuclease G multiple signaling.Exploiting the mitochondrial unfolded protein response for cancer therapy in mice and human cellsInvestigation of cyanine dyes for in vivo optical imaging of altered mitochondrial membrane potential in tumors.Mitochondrial Medicine and the Neurodegenerative Mitochondriopathies.High-throughput screening of FDA-approved drugs using oxygen biosensor plates reveals secondary mitofunctional effects.Role and treatment of mitochondrial DNA-related mitochondrial dysfunction in sporadic neurodegenerative diseases.Phenethyl Isothiocyanate (PEITC) Inhibits the Growth of Human Oral Squamous Carcinoma HSC-3 Cells through G(0)/G(1) Phase Arrest and Mitochondria-Mediated Apoptotic Cell Death.The Roots of Atractylodes macrocephala Koidzumi Enhanced Glucose and Lipid Metabolism in C2C12 Myotubes via Mitochondrial Regulation.Unique antitumor property of the Mg-Ca-Sr alloys with addition of Zn.Mitochondrial functions on oocytes and preimplantation embryosMeclizine inhibits mitochondrial respiration through direct targeting of cytosolic phosphoethanolamine metabolism.Compartmentalized cancer drug discovery targeting mitochondrial Hsp90 chaperones.The emerging role of cardiovascular risk factor-induced mitochondrial dysfunction in atherogenesis.3'-Daidzein sulfonate sodium improves mitochondrial functions after cerebral ischemia/reperfusion injury.Targeting the mitochondrial permeability transition: cardiac ischemia-reperfusion versus carcinogenesis.Mitochondria as a pharmacological target: magnum overview.Nanopreparations for organelle-specific delivery in cancerDelivery aspects of antioxidants in diabetes management.Inhibition of stress-inducible HSP70 impairs mitochondrial proteostasis and function.Targeting adipose tissue in the treatment of obesity-associated diabetes.Hydrophobized triphenyl phosphonium derivatives for the preparation of mitochondriotropic liposomes: choice of hydrophobic anchor influences cytotoxicity but not mitochondriotropic effect.Mitochondrial delivery of doxorubicin by triphenylphosphonium-functionalized hyperbranched nanocarriers results in rapid and severe cytotoxicity.Mitochondrial function is involved in regulation of cholesterol efflux to apolipoprotein (apo)A-I from murine RAW 264.7 macrophages.Prospects for therapeutic mitochondrial transplantation.Mitochondria-Targeted Triphenylphosphonium-Based Compounds: Syntheses, Mechanisms of Action, and Therapeutic and Diagnostic Applications.Gold(I) complexes of water-soluble diphos-type ligands: synthesis, anticancer activity, apoptosis and thioredoxin reductase inhibition.Bz-423 superoxide signals apoptosis via selective activation of JNK, Bak, and BaxSynthesis of triphenylphosphonium vitamin E derivatives as mitochondria-targeted antioxidants.Toxicity of Arsenic (III) on Isolated Liver Mitochondria: A New Mechanistic Approach.Synthesis and characterization of mitoQ and idebenone analogues as mediators of oxygen consumption in mitochondria.MitoBlue: a nontoxic and photostable blue-emitting dye that selectively labels functional mitochondria.
P2860
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P2860
Mitochondrial medicine: pharmacological targeting of mitochondria in disease
description
2007 nî lūn-bûn
@nan
2007年の論文
@ja
2007年学术文章
@wuu
2007年学术文章
@zh-cn
2007年学术文章
@zh-hans
2007年学术文章
@zh-my
2007年学术文章
@zh-sg
2007年學術文章
@yue
2007年學術文章
@zh
2007年學術文章
@zh-hant
name
Mitochondrial medicine: pharmacological targeting of mitochondria in disease
@ast
Mitochondrial medicine: pharmacological targeting of mitochondria in disease
@en
type
label
Mitochondrial medicine: pharmacological targeting of mitochondria in disease
@ast
Mitochondrial medicine: pharmacological targeting of mitochondria in disease
@en
prefLabel
Mitochondrial medicine: pharmacological targeting of mitochondria in disease
@ast
Mitochondrial medicine: pharmacological targeting of mitochondria in disease
@en
P2860
P356
P1476
Mitochondrial medicine: pharmacological targeting of mitochondria in disease
@en
P2093
J S Armstrong
P2860
P304
P356
10.1038/SJ.BJP.0707288
P407
P577
2007-05-21T00:00:00Z