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Exploiting the mitochondrial unfolded protein response for cancer therapy in mice and human cells

Exploiting the mitochondrial unfolded protein response for cancer therapy in mice and human cells

http://www.wikidata.org/entity/Q34755334

about

Cancer cells exploit adaptive mitochondrial dynamics to increase tumor cell invasion Mitochondrial signaling: forwards, backwards, and in between Metabolic stress regulates cytoskeletal dynamics and metastasis of cancer cells.Mitochondrial Hsp90s suppress calcium-mediated stress signals propagating from mitochondria to the ER in cancer cells Combination treatment with doxorubicin and gamitrinib synergistically augments anticancer activity through enhanced activation of Bim.Signaling the mitochondrial unfolded protein response.Utilization of the cellular stress response to sensitize cancer cells to TRAIL-mediated apoptosis.SirT3 regulates the mitochondrial unfolded protein response.TRAP1 controls mitochondrial fusion/fission balance through Drp1 and Mff expression Targeted protein destabilization reveals an estrogen-mediated ER stress response.The complex interplay between autophagy and NF-κB signaling pathways in cancer cells Hyperactivation of oxidative mitochondrial metabolism in epithelial cancer cells in situ: visualizing the therapeutic effects of metformin in tumor tissue.Induction of dsRNA-activated protein kinase links mitochondrial unfolded protein response to the pathogenesis of intestinal inflammation.Unfolded protein stress in the endoplasmic reticulum and mitochondria: a role in neurodegeneration Combined inhibition of Bcl-2/Bcl-xL and Usp9X/Bag3 overcomes apoptotic resistance in glioblastoma in vitro and in vivo.The Mitochondrial Unfoldase-Peptidase Complex ClpXP Controls Bioenergetics Stress and Metastasis.Disabling mitochondrial reprogramming in cancer Molecular Pathways: Mitochondrial Reprogramming in Tumor Progression and Therapy.TIC10/ONC201 synergizes with Bcl-2/Bcl-xL inhibition in glioblastoma by suppression of Mcl-1 and its binding partners in vitro and in vivo.Cyclophilin D extramitochondrial signaling controls cell cycle progression and chemokine-directed cell motility.Control of tumor bioenergetics and survival stress signaling by mitochondrial HSP90s.Inhibition of the mitochondrial unfolded protein response by acetylcholine alleviated hypoxia/reoxygenation-induced apoptosis of endothelial cells Inhibition of deubiquitinases primes glioblastoma cells to apoptosis in vitro and in vivo.Hsp90 regulation of mitochondrial protein folding: from organelle integrity to cellular homeostasis Landscape of the mitochondrial Hsp90 metabolome in tumours Metabolic reprogramming of glioblastoma cells by L-asparaginase sensitizes for apoptosis in vitro and in vivo Down-modulation of SEL1L, an unfolded protein response and endoplasmic reticulum-associated degradation protein, sensitizes glioma stem cells to the cytotoxic effect of valproic acid.Inhibition of human mitochondrial peptide deformylase causes apoptosis in c-myc-overexpressing hematopoietic cancers.Mitochondrial compartmentalized protein folding and tumor cell survival.TRAP-1, the mitochondrial Hsp90.New insights into TRAP1 pathway.Targeting malignant mitochondria with therapeutic peptides.TRAP1: a viable therapeutic target for future cancer treatments?Inhibition of stress-inducible HSP70 impairs mitochondrial proteostasis and function.PARP inhibition restores extrinsic apoptotic sensitivity in glioblastoma.Mitochondrial dysfunction in cancer: Potential roles of ATF5 and the mitochondrial UPR.TRAP1 and the proteasome regulatory particle TBP7/Rpt3 interact in the endoplasmic reticulum and control cellular ubiquitination of specific mitochondrial proteins.A Synthetic Cell-Penetrating Dominant-Negative ATF5 Peptide Exerts Anticancer Activity against a Broad Spectrum of Treatment-Resistant Cancers.Mitochondrial matrix chaperone and c-myc inhibition causes enhanced lethality in glioblastoma.Resistance to paclitxel in breast carcinoma cells requires a quality control of mitochondrial antiapoptotic proteins by TRAP1.

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Exploiting the mitochondrial unfolded protein response for cancer therapy in mice and human cells

http://www.wikidata.org/entity/Q34755334

description

2011 nî lūn-bûn

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2011 թուականի Ապրիլին հրատարակուած գիտական յօդուած

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2011 թվականի ապրիլին հրատարակված գիտական հոդված

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2011年の論文

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2011年論文

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2011年論文

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Exploiting the mitochondrial u ...... erapy in mice and human cells

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Exploiting the mitochondrial u ...... erapy in mice and human cells

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Exploiting the mitochondrial u ...... erapy in mice and human cells

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Exploiting the mitochondrial u ...... erapy in mice and human cells

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Alonzo H Ross

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Candace A Gilbert

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Christine M Powers

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Christopher M Raskett

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Dario C Altieri

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Gregory M Orlowski

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Janet Plescia

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Markus D Siegelin

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Takehiko Dohi

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P2860

Molecular chaperones Hsp90 and Hsp70 deliver preproteins to the mitochondrial import receptor Tom70

Pharmacological manipulation of cell death: clinical applications in sight?

Is NF-kappaB a good target for cancer therapy? Hopes and pitfalls

Combinatorial drug design targeting multiple cancer signaling networks controlled by mitochondrial Hsp90

Autophagy suppresses tumorigenesis through elimination of p62

Autophagy in the Pathogenesis of Disease

Signal integration in the endoplasmic reticulum unfolded protein response

Functional and genomic analyses reveal an essential coordination between the unfolded protein response and ER-associated degradation

Sigma-1 receptor chaperones at the ER-mitochondrion interface regulate Ca(2+) signaling and cell survival

Targeting the dynamic HSP90 complex in cancer

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1349-1360

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10.1172/JCI44855

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4

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21364280

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