Higher autoantibody levels and recognition of a linear NH2-terminal epitope in the autoantigen GAD65, distinguish stiff-man syndrome from insulin-dependent diabetes mellitus.
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Homozygosity for a missense mutation in the 67 kDa isoform of glutamate decarboxylase in a family with autosomal recessive spastic cerebral palsy: parallels with Stiff-Person Syndrome and other movement disordersAntigen Presentation, Autoantigens, and Immune Regulation in Multiple Sclerosis and Other Autoimmune DiseasesProduction of the islet cell antigen ICA69 (p69) with baculovirus expression system: analysis with a solid-phase time-resolved fluorescence method of sera from patients with IDDM and rheumatoid arthritisAutoimmune stiff person syndrome and related myelopathies: understanding of electrophysiological and immunological processes.Phosphorylation of serine residues 3, 6, 10, and 13 distinguishes membrane anchored from soluble glutamic acid decarboxylase 65 and is restricted to glutamic acid decarboxylase 65alphaRarity of autoantibodies to a major autoantigen, thyroid peroxidase, that interact with denatured antigen or with epitopes outside the immunodominant region.Distinct antigenic features of linear epitopes at the N-terminus and C-terminus of 65 kDa glutamic acid decarboxylase (GAD65): implications for autoantigen modification during pathogenesis.High titers of autoantibodies to glutamate decarboxylase in type 1 diabetes patients: epitope analysis and inhibition of enzyme activity.Stiff-man syndrome: from the bedside to the bench.Epilepsy in mice deficient in the 65-kDa isoform of glutamic acid decarboxylase.An analysis of the cross-reactivity of autoantibodies to GAD65 and GAD67 in diabetes.A versatile protein microarray platform enabling antibody profiling against denatured proteinsPathogenic Roles of Glutamic Acid Decarboxylase 65 Autoantibodies in Cerebellar AtaxiasHigh definition profiling of autoantibodies to glutamic acid decarboxylases GAD65/GAD67 in stiff-person syndrome.Antibodies to inhibitory synaptic proteins in neurological syndromes associated with glutamic acid decarboxylase autoimmunity.Autoimmune diabetes: more than just one flavor?Detection of Antibodies Directed to the N-Terminal Region of GAD Is Dependent on Assay Format and Contributes to Differences in the Specificity of GAD Autoantibody Assays for Type 1 Diabetes.A Case of Stiff Person Syndrome: Immunomodulatory Effect of Benzodiazepines: Successful Rituximab and Tizanidine Therapy.Antigen presentation of detergent-free glutamate decarboxylase (GAD65) is affected by human serum albumin as carrier protein.Immunobiology of stiff-person syndrome.Islet autoantibody testing: an end to the trials and tribulations?Immunology of stiff person syndrome and other GAD-associated neurological disorders.Stiff-person syndrome: insights into a complex autoimmune disorder.Relationship of the 37,000- and 40,000-M(r) tryptic fragments of islet antigens in insulin-dependent diabetes to the protein tyrosine phosphatase-like molecule IA-2 (ICA512).Adaptive Immunity Is the Key to the Understanding of Autoimmune and Paraneoplastic Inflammatory Central Nervous System Disorders.The clinical significance of an autoimmune response against glutamic acid decarboxylase.Islet cell autoantigens in type 1 diabetes.Immune-mediated cerebellar ataxias: from bench to bedside.Epilepsy and behavioral changes, type 1 diabetes mellitus and a high titer of glutamic acid decarboxylase antibodies.Human peptidome display.Preservation of enzyme activity and antigenicity after mutagenesis of the membrane anchoring domain of GAD65.Review of the potential health impact of β-casomorphins and related peptidesMultiplex family with GAD65-Abs neurologic syndromes.Activity-dependent cleavage of brain glutamic acid decarboxylase 65 by calpain.Detection of anti-glutamic acid decarboxylase antibodies in immunoglobulin products.Epitope-specific glutamic acid decarboxylase-65 autoantibodies in intravenous immunoglobulin preparations.GAD65 autoantibody characteristics in patients with co-occurring type 1 diabetes and epilepsy may help identify underlying epilepsy etiologies.
P2860
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P2860
Higher autoantibody levels and recognition of a linear NH2-terminal epitope in the autoantigen GAD65, distinguish stiff-man syndrome from insulin-dependent diabetes mellitus.
description
1994 nî lūn-bûn
@nan
1994年の論文
@ja
1994年学术文章
@wuu
1994年学术文章
@zh-cn
1994年学术文章
@zh-hans
1994年学术文章
@zh-my
1994年学术文章
@zh-sg
1994年學術文章
@yue
1994年學術文章
@zh
1994年學術文章
@zh-hant
name
Higher autoantibody levels and ...... n-dependent diabetes mellitus.
@ast
Higher autoantibody levels and ...... n-dependent diabetes mellitus.
@en
type
label
Higher autoantibody levels and ...... n-dependent diabetes mellitus.
@ast
Higher autoantibody levels and ...... n-dependent diabetes mellitus.
@en
prefLabel
Higher autoantibody levels and ...... n-dependent diabetes mellitus.
@ast
Higher autoantibody levels and ...... n-dependent diabetes mellitus.
@en
P2093
P2860
P356
P1476
Higher autoantibody levels and ...... in-dependent diabetes mellitus
@en
P2093
H J Aanstoot
P2860
P304
P356
10.1084/JEM.180.2.595
P407
P577
1994-08-01T00:00:00Z