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Advances in pancreatic islet monolayer culture on glass surfaces enable super-resolution microscopy and insights into beta cell ciliogenesis and proliferation.Does GAD have a unique role in triggering IDDM?Increased anxiety and altered responses to anxiolytics in mice deficient in the 65-kDa isoform of glutamic acid decarboxylase.Compartmentalization of GABA synthesis by GAD67 differs between pancreatic beta cells and neuronsA combination of three distinct trafficking signals mediates axonal targeting and presynaptic clustering of GAD65Higher autoantibody levels and recognition of a linear NH2-terminal epitope in the autoantigen GAD65, distinguish stiff-man syndrome from insulin-dependent diabetes mellitus.Homing of GAD65 specific autoimmunity and development of insulitis requires expression of both DQ8 and human GAD65 in transgenic mice.Identification and characterization of glima 38, a glycosylated islet cell membrane antigen, which together with GAD65 and IA2 marks the early phases of autoimmune response in type 1 diabetes.Palmitoylation cycles and regulation of protein function (Review).Primary Human and Rat β-Cells Release the Intracellular Autoantigens GAD65, IA-2, and Proinsulin in Exosomes Together With Cytokine-Induced Enhancers of Immunity.Aberrant Accumulation of the Diabetes Autoantigen GAD65 in Golgi Membranes in Conditions of ER Stress and AutoimmunityBioengineering strategies for inducing tolerance in autoimmune diabetes.Local GABA circuit control of experience-dependent plasticity in developing visual cortex.The glutamate decarboxylase and 38KD autoantigens in type 1 diabetes: aspects of structure and epitope recognition.Cellular and subcellular localization of an Mr 64,000 protein autoantigen in insulin-dependent diabetes.Differential expression of GAD65 and GAD67 in human, rat, and mouse pancreatic islets.Glutamate decarboxylase and GABA in pancreatic islets: lessons from knock-out mice.A non-cleavable mutant of Fas ligand does not prevent neutrophilic destruction of islet transplants.Increased expression of GAD65 and GABA in pancreatic beta-cells impairs first-phase insulin secretion.Coordinate expression of the endogenous p53 gene in beta cells of transgenic mice expressing hybrid insulin-SV40 T antigen genesCorrigendum: Advances in pancreatic islet monolayer culture on glass surfaces enable super-resolution microscopy and insights into beta cell ciliogenesis and proliferation.Palmitoylation controls trafficking of GAD65 from Golgi membranes to axon-specific endosomes and a Rab5a-dependent pathway to presynaptic clusters.Differential protection in two transgenic lines of NOD/Lt mice hyperexpressing the autoantigen GAD65 in pancreatic beta-cells.Autoantibodies in newly diagnosed diabetic children immunoprecipitate human pancreatic islet cell proteinsHigh-resolution autoreactive epitope mapping and structural modeling of the 65 kDa form of human glutamic acid decarboxylaseAntibodies to a Mr-64000 islet cell protein in Swedish children with newly diagnosed Type 1 (insulin-dependent) diabetesPancreatic beta cells express two autoantigenic forms of glutamic acid decarboxylase, a 65-kDa hydrophilic form and a 64-kDa amphiphilic form which can be both membrane-bound and solubleImmunoreactivity to a 64,000 Mr human islet cell antigen in sera from insulin-dependent diabetes mellitus patients and individuals with abnormal glucose toleranceIslet cell and 64K autoantibodies are associated with plasma IgG in newly diagnosed insulin-dependent diabetic childrenRevelation of specificity of 64K autoantibodies in IDDM serums by high-resolution 2-D gel electrophoresis. Unambiguous identification of 64K target antigenStudies of the isolation and viability of human islets of LangerhansIslet cell antibodies-theoretical and practical implicationsA beta-cell glycoprotein of Mr 40 000 is the major rat islet cell immunogen following xenogenic immunisationRodent islet cell antigens recognized by antibodies in sera from diabetic patientsIslet transplantation in mice differing in the I and S subregions of the H-2 complexGlucose stimulates the biosynthesis of a human pancreatic islet cell protein detected by an antiserum against the human erythrocyte glucose transporterTransfer of type 1 (insulin-dependent) diabetes mellitus associated autoimmunity to mice with severe combined immunodeficiency (SCID)Sub-cellular fractionation of Trypanosoma brucei. Isolation and characterization of plasma membranes
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description
Forscher
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Baekkeskov S
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Baekkeskov S
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Baekkeskov S
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Steinunn Baekkeskov
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Steinunn Baekkeskov
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Baekkeskov S
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Baekkeskov S
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Baekkeskov S
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Baekkeskov S
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Steinunn Baekkeskov
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P31
P496
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