Developmentally regulated expression of CD3 components independent of clonotypic T cell antigen receptor complexes on immature thymocytes.
about
Incomplete endoplasmic reticulum (ER) retention in immature thymocytes as revealed by surface expression of "ER-resident" molecular chaperonesCalnexin associates exclusively with individual CD3 delta and T cell antigen receptor (TCR) alpha proteins containing incompletely trimmed glycans that are not assembled into multisubunit TCR complexesThe CD3gamma chain is essential for development of both the TCRalphabeta and TCRgammadelta lineages.Essential and partially overlapping role of CD3gamma and CD3delta for development of alphabeta and gammadelta T lymphocytesAn orderly inactivation of intracellular retention signals controls surface expression of the T cell antigen receptor.Specific requirement for CD3epsilon in T cell development.Alterations in the expression pattern of TCR zeta chain in T cells from patients with hematological diseases.The molecular chaperone calnexin is expressed on the surface of immature thymocytes in association with clonotype-independent CD3 complexes.Altered T cell development in mice with a targeted mutation of the CD3-epsilon gene.A comprehensive characterization of the T-cell antigen receptor complex composition by microcapillary liquid chromatography-tandem mass spectrometry.The related molecular chaperones calnexin and calreticulin differentially associate with nascent T cell antigen receptor proteins within the endoplasmic reticulum.Insights into T cell development and signal transduction provided by TCR-zeta chain deficient mice.Conformational changes in the T cell receptor differentially determine T cell subset development in mice.Developmentally regulated expression of the transmembrane adaptor protein trim in fetal and adult T cells.CD4-CD8-C.B-17 SCID thymocytes enter the CD4+CD8+ stage in the presence of neonatally grafted T cells.Calnexin associates with monomeric and oligomeric (disulfide-linked) CD3delta proteins in murine T lymphocytes.Immature thymocytes that fail to express TCRbeta and/or TCRgamma delta proteins die by apoptotic cell death in the CD44(-)CD25(-) (DN4) subset.
P2860
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P2860
Developmentally regulated expression of CD3 components independent of clonotypic T cell antigen receptor complexes on immature thymocytes.
description
1994 nî lūn-bûn
@nan
1994年の論文
@ja
1994年学术文章
@wuu
1994年学术文章
@zh-cn
1994年学术文章
@zh-hans
1994年学术文章
@zh-my
1994年学术文章
@zh-sg
1994年學術文章
@yue
1994年學術文章
@zh
1994年學術文章
@zh-hant
name
Developmentally regulated expr ...... plexes on immature thymocytes.
@ast
Developmentally regulated expr ...... plexes on immature thymocytes.
@en
type
label
Developmentally regulated expr ...... plexes on immature thymocytes.
@ast
Developmentally regulated expr ...... plexes on immature thymocytes.
@en
prefLabel
Developmentally regulated expr ...... plexes on immature thymocytes.
@ast
Developmentally regulated expr ...... plexes on immature thymocytes.
@en
P2093
P2860
P356
P1476
Developmentally regulated expr ...... plexes on immature thymocytes.
@en
P2093
P2860
P304
P356
10.1084/JEM.180.4.1375
P407
P577
1994-10-01T00:00:00Z