Arginase II Promotes Macrophage Inflammatory Responses Through Mitochondrial Reactive Oxygen Species, Contributing to Insulin Resistance and Atherogenesis
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Arginase as a Critical Prooxidant Mediator in the Binomial Endothelial Dysfunction-AtherosclerosisReactive oxygen species in inflammation and tissue injuryLong term exposure to L-arginine accelerates endothelial cell senescence through arginase-II and S6K1 signalingHuman papillomavirus e7 oncoprotein transgenic skin develops an enhanced inflammatory response to 2,4-dinitrochlorobenzene by an arginase-1-dependent mechanism.Functions of arginase isoforms in macrophage inflammatory responses: impact on cardiovascular diseases and metabolic disorders.Label-free quantitative urinary proteomics identifies the arginase pathway as a new player in congenital obstructive nephropathy.Arginase inhibition augments nitric oxide production and facilitates left ventricular systolic function in doxorubicin-induced cardiomyopathy in mice.Increased endothelial inflammation, sTie-2 and arginase activity in umbilical cords obtained from gestational diabetic mothersRole of p38 mitogen-activated protein kinase in vascular endothelial aging: interaction with Arginase-II and S6K1 signaling pathwayp38 mitogen-activated protein kinase is involved in arginase-II-mediated eNOS-uncoupling in obesityARG2 impairs endothelial autophagy through regulation of MTOR and PRKAA/AMPK signaling in advanced atherosclerosis.Arginase inhibition attenuates arteriogenesis and interferes with M2 macrophage accumulation.Arginase-I enhances vascular endothelial inflammation and senescence through eNOS-uncoupling.Targeting arginase-II protects mice from high-fat-diet-induced hepatic steatosis through suppression of macrophage inflammation.Mincle-mediated translational regulation is required for strong nitric oxide production and inflammation resolution.Role of arginase in vessel wall remodeling.Arginase promotes skeletal muscle arteriolar endothelial dysfunction in diabetic ratsArginase: the emerging therapeutic target for vascular oxidative stress and inflammation.Arginase inhibition mediates renal tissue protection in diabetic nephropathy by a nitric oxide synthase 3-dependent mechanismArginase-II induces vascular smooth muscle cell senescence and apoptosis through p66Shc and p53 independently of its l-arginine ureahydrolase activity: implications for atherosclerotic plaque vulnerabilityGenetic Targeting of Arginase-II in Mouse Prevents Renal Oxidative Stress and Inflammation in Diet-Induced Obesity.Molecular biology of atherosclerosis.Molecular pathways of arterial aging.PKCη deficiency improves lipid metabolism and atherosclerosis in apolipoprotein E-deficient mice.Arginase-II Deficiency Extends Lifespan in Mice.Microbiota of Chronic Diabetic Wounds: Ecology, Impact, and Potential for Innovative Treatment Strategies.Polarization of Macrophages toward M2 Phenotype Is Favored by Reduction in iPLA2β (Group VIA Phospholipase A2)Arginase II: atherogenesis beyond enzyme activity.Increased levels of circulating arginase I in overweight compared to normal weight adolescents.Arginase II inhibition prevents interleukin-8 production through regulation of p38 MAPK phosphorylation activated by loss of mitochondrial membrane potential in nLDL-stimulated hAoSMCs.Long-term dietary restriction up-regulates activity and expression of renal arginase II in aging mice.Deficient Arginase II Expression without Alteration in Arginase I Expression Attenuated Experimental Autoimmune Encephalomyelitis in Mice.Kidney Mass Reduction Leads to l-Arginine Metabolism-Dependent Blood Pressure Increase in Mice.Arginase inhibition prevents the development of hypertension and improves insulin resistance in obese rats.Asymmetric dimethylarginine (ADMA) elevation and arginase up-regulation contribute to endothelial dysfunction related to insulin resistance in rats and morbidly obese humans.Elevated levels of plasma symmetric dimethylarginine and increased arginase activity as potential indicators of cardiovascular comorbidity in rheumatoid arthritis.
P2860
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P2860
Arginase II Promotes Macrophage Inflammatory Responses Through Mitochondrial Reactive Oxygen Species, Contributing to Insulin Resistance and Atherogenesis
description
2012 nî lūn-bûn
@nan
2012年の論文
@ja
2012年学术文章
@wuu
2012年学术文章
@zh-cn
2012年学术文章
@zh-hans
2012年学术文章
@zh-my
2012年学术文章
@zh-sg
2012年學術文章
@yue
2012年學術文章
@zh
2012年學術文章
@zh-hant
name
Arginase II Promotes Macrophag ...... n Resistance and Atherogenesis
@ast
Arginase II Promotes Macrophag ...... n Resistance and Atherogenesis
@en
type
label
Arginase II Promotes Macrophag ...... n Resistance and Atherogenesis
@ast
Arginase II Promotes Macrophag ...... n Resistance and Atherogenesis
@en
prefLabel
Arginase II Promotes Macrophag ...... n Resistance and Atherogenesis
@ast
Arginase II Promotes Macrophag ...... n Resistance and Atherogenesis
@en
P2093
P2860
P356
P1476
Arginase II Promotes Macrophag ...... n Resistance and Atherogenesis
@en
P2093
Angana G Rajapakse
Brenda R Kwak
Claudio Sartori
Isabelle Scerri
Jean Ruffieux
Jean-Pierre Montani
Jianhui Li
Katja Popp
Urs Scherrer
Xiu-Fen Ming
P2860
P304
P356
10.1161/JAHA.112.000992
P577
2012-08-24T00:00:00Z