CTLA-4 engagement inhibits IL-2 accumulation and cell cycle progression upon activation of resting T cells
about
Down-regulation of CTLA-4 by HIV-1 Nef proteinMigration of Th1 lymphocytes is regulated by CD152 (CTLA-4)-mediated signaling via PI3 kinase-dependent Akt activationICOS is an inducible T-cell co-stimulator structurally and functionally related to CD28B7-H3: a costimulatory molecule for T cell activation and IFN-gamma productionFc-dependent depletion of tumor-infiltrating regulatory T cells co-defines the efficacy of anti-CTLA-4 therapy against melanomaMolecular modeling and functional mapping of B7-H1 and B7-DC uncouple costimulatory function from PD-1 interactionLigand binding sites of inducible costimulator and high avidity mutants with improved functionCytotoxic T lymphocyte-associated antigen 4 plays an essential role in the function of CD25(+)CD4(+) regulatory cells that control intestinal inflammationCancer regression and autoimmunity induced by cytotoxic T lymphocyte-associated antigen 4 blockade in patients with metastatic melanomaMultiple functions for CD28 and cytotoxic T lymphocyte antigen-4 during different phases of T cell responses: implications for arthritis and autoimmune diseasesClinical Development of the E75 Vaccine in Breast CancerCheckpoint Inhibitors and Their Application in Breast CancerInduction of CD4(+) Regulatory and Polarized Effector/helper T Cells by Dendritic CellsThe Role of Alternative Splicing in the Control of Immune Homeostasis and Cellular DifferentiationCTLA-4 and PD-1 Pathways: Similarities, Differences, and Implications of Their InhibitionImmune Checkpoint Blockade in Cancer TherapyA bispecific protein capable of engaging CTLA-4 and MHCII protects non-obese diabetic mice from autoimmune diabetesRationale for a Multimodality Strategy to Enhance the Efficacy of Dendritic Cell-Based Cancer Immunotherapy.T-cell exhaustion in chronic hepatitis B infection: current knowledge and clinical significanceCostimulation of T cellsThe two SH2-domain-containing inositol 5-phosphatases SHIP1 and SHIP2 are coexpressed in human T lymphocytesA cellular calculus for signal integration by T cellsUnifying concepts in CD28, ICOS and CTLA4 co-receptor signallingImmune dysregulation in human subjects with heterozygous germline mutations in CTLA4Biologic and immunomodulatory events after CTLA-4 blockade with ticilimumab in patients with advanced malignant melanomaCombination CTLA-4 blockade and 4-1BB activation enhances tumor rejection by increasing T-cell infiltration, proliferation, and cytokine productionModulation of cell signaling networks after CTLA4 blockade in patients with metastatic melanomaFunctional analysis of the T-cell-restricted protein tyrosine kinase Txk.CD80 cytoplasmic domain controls localization of CD28, CTLA-4, and protein kinase Ctheta in the immunological synapseMolecular characterization and applications of recombinant scFv antibodies to CD152 co-stimulatory molecule.CTLA-4 interacts with STAT5 and inhibits STAT5-mediated transcription.Co-expression of sCD40LIg and CTLA4Ig mediated by adenovirus prolonged mouse skin allograft survival.Site-directed in vitro immunization leads to a complete human monoclonal IgG4 lambda that binds specifically to the CDR2 region of CTLA-4 (CD152) without interfering the engagement of natural ligandsCD152 (CTLA-4) determines CD4 T cell migration in vitro and in vivo.Expression of the costimulatory molecule B7-H3 is associated with prolonged survival in human pancreatic cancerThe role of CTLA-4 in the regulation of T cell immune responses.Mechanism of tumor rejection with doublets of CTLA-4, PD-1/PD-L1, or IDO blockade involves restored IL-2 production and proliferation of CD8(+) T cells directly within the tumor microenvironment.Genetic analysis of the exon 1 position 49 CD152 dimorphism in multiple sclerosisPlacental immunopathology in the FIV-infected cat: a role for inflammation in compromised pregnancy?Role of CTLA-4, IL-18 and IL-10 on the Induction of Low Dose Oral Tolerance.
P2860
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P2860
CTLA-4 engagement inhibits IL-2 accumulation and cell cycle progression upon activation of resting T cells
description
1996 nî lūn-bûn
@nan
1996年の論文
@ja
1996年学术文章
@wuu
1996年学术文章
@zh-cn
1996年学术文章
@zh-hans
1996年学术文章
@zh-my
1996年学术文章
@zh-sg
1996年學術文章
@yue
1996年學術文章
@zh
1996年學術文章
@zh-hant
name
CTLA-4 engagement inhibits IL- ...... activation of resting T cells
@ast
CTLA-4 engagement inhibits IL- ...... activation of resting T cells
@en
type
label
CTLA-4 engagement inhibits IL- ...... activation of resting T cells
@ast
CTLA-4 engagement inhibits IL- ...... activation of resting T cells
@en
prefLabel
CTLA-4 engagement inhibits IL- ...... activation of resting T cells
@ast
CTLA-4 engagement inhibits IL- ...... activation of resting T cells
@en
P2860
P356
P1476
CTLA-4 engagement inhibits IL- ...... activation of resting T cells
@en
P2093
M F Krummel
P2860
P304
P356
10.1084/JEM.183.6.2533
P407
P577
1996-06-01T00:00:00Z