CD80 cytoplasmic domain controls localization of CD28, CTLA-4, and protein kinase Ctheta in the immunological synapse
about
Action and Traction: Cytoskeletal Control of Receptor Triggering at the Immunological SynapseCell Type-Specific Regulation of Immunological Synapse Dynamics by B7 Ligand RecognitionInvestigative and clinical applications of synthetic immune synapsesMicro- and nanoscale engineering of cell signalingT cell receptor microcluster transport through molecular mazes reveals mechanism of translocation.Micropatterning of costimulatory ligands enhances CD4+ T cell function.Spatiotemporal regulation of T cell costimulation by TCR-CD28 microclusters and protein kinase C theta translocation.Signals and sequences that control CD28 localization to the central region of the immunological synapse.Nanoscale increases in CD2-CD48-mediated intermembrane spacing decrease adhesion and reorganize the immunological synapseCD80 and CD86 differentially regulate mechanical interactions of T-cells with antigen-presenting dendritic cells and B-cells.T cell-dendritic cell immunological synapses contain TCR-dependent CD28-CD80 clusters that recruit protein kinase C theta.Nanoengineering of Immune Cell Function.The dendritic cell cytoskeleton promotes T cell adhesion and activation by constraining ICAM-1 mobilityTumor cell programmed death ligand 1-mediated T cell suppression is overcome by coexpression of CD80Substrate rigidity regulates human T cell activation and proliferationA microfluidic platform reveals differential response of regulatory T cells to micropatterned costimulation arrays.Distinct sites within the vascular cell adhesion molecule-1 (VCAM-1) cytoplasmic domain regulate VCAM-1 activation of calcium fluxes versus Rac1 during leukocyte transendothelial migration.Th1 and Th2 cells form morphologically distinct immunological synapses.The role of integrins and coreceptors in refining thresholds for B-cell responses.T-cell activation through immunological synapses and kinapses.Coordinate control of cytoskeletal remodeling and calcium mobilization during T-cell activationSelf-aligned supported lipid bilayers for patterning the cell-substrate interface.Cutting edge: NKG2D-dependent cytotoxicity is controlled by ligand distribution in the target cell membrane.Tethering of intercellular adhesion molecule on target cells is required for LFA-1-dependent NK cell adhesion and granule polarization.Dynamic regulation of T-cell costimulation through TCR-CD28 microclusters.Regulating the regulators: costimulatory signals control the homeostasis and function of regulatory T cells.The yin and yang of protein kinase C-theta (PKCθ): a novel drug target for selective immunosuppression.Cross talk between CD3 and CD28 is spatially modulated by protein lateral mobilityDiversity in immunological synapse structure.Microfabricated platforms to modulate and monitor T cell synapse assembly.T cell-encoded CD80 and 4-1BBL induce auto- and transcostimulation, resulting in potent tumor rejection.Visualization of Cell-Cell Interaction Contacts: Synapses and Kinapses.The bullseye synapse formed between CD4+ T-cell and staphylococcal enterotoxin B-pulsed dendritic cell is a suppressive synapse in T-cell response.
P2860
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P2860
CD80 cytoplasmic domain controls localization of CD28, CTLA-4, and protein kinase Ctheta in the immunological synapse
description
2005 nî lūn-bûn
@nan
2005 թուականի Դեկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2005 թվականի դեկտեմբերին հրատարակված գիտական հոդված
@hy
2005年の論文
@ja
2005年論文
@yue
2005年論文
@zh-hant
2005年論文
@zh-hk
2005年論文
@zh-mo
2005年論文
@zh-tw
2005年论文
@wuu
name
CD80 cytoplasmic domain contro ...... a in the immunological synapse
@ast
CD80 cytoplasmic domain contro ...... a in the immunological synapse
@en
type
label
CD80 cytoplasmic domain contro ...... a in the immunological synapse
@ast
CD80 cytoplasmic domain contro ...... a in the immunological synapse
@en
prefLabel
CD80 cytoplasmic domain contro ...... a in the immunological synapse
@ast
CD80 cytoplasmic domain contro ...... a in the immunological synapse
@en
P2860
P1476
CD80 cytoplasmic domain contro ...... a in the immunological synapse
@en
P2093
Su-Yi Tseng
P2860
P304
P356
10.4049/JIMMUNOL.175.12.7829
P407
P577
2005-12-01T00:00:00Z