Mechanisms of arsenical and diamidine uptake and resistance in Trypanosoma brucei.
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Structure-Based Design and Synthesis of Antiparasitic Pyrrolopyrimidines Targeting Pteridine Reductase 1Exploiting the Achilles' heel of membrane trafficking in trypanosomesNew Approaches to Overcome Transport Related Drug Resistance in Trypanosomatid ParasitesPreclinical assessment of the treatment of second-stage African trypanosomiasis with cordycepin and deoxycoformycinGenotypic status of the TbAT1/P2 adenosine transporter of Trypanosoma brucei gambiense isolates from Northwestern Uganda following melarsoprol withdrawalAquaporin 2 mutations in Trypanosoma brucei gambiense field isolates correlate with decreased susceptibility to pentamidine and melarsoprolMelarsoprol sensitivity profile of Trypanosoma brucei gambiense isolates from cured and relapsed sleeping sickness patients from the Democratic Republic of the CongoSpecific Cell Targeting Therapy Bypasses Drug Resistance Mechanisms in African TrypanosomiasisAn Atypical Mitochondrial Carrier That Mediates Drug Action in Trypanosoma bruceiTransport proteins determine drug sensitivity and resistance in a protozoan parasite, Trypanosoma bruceiA luciferase based viability assay for ATP detection in 384-well format for high throughput whole cell screening of Trypanosoma brucei brucei bloodstream form strain 427.2,N6-disubstituted adenosine analogs with antitrypanosomal and antimalarial activities.Evaluation of nucleoside hydrolase inhibitors for treatment of African trypanosomiasisPredictive computational models of substrate binding by a nucleoside transporter.Functional and genetic evidence that nucleoside transport is highly conserved in Leishmania species: Implications for pyrimidine-based chemotherapy.Multiple genetic mechanisms lead to loss of functional TbAT1 expression in drug-resistant trypanosomes.Immunobiology of African trypanosomes: need of alternative interventionsSymmetrical choline-derived dications display strong anti-kinetoplastid activity.In vitro and in vivo evaluation of 28DAP010, a novel diamidine for treatment of second-stage African sleeping sicknessAn essential farnesylated kinesin in Trypanosoma brucei.Selective delivery of 2-hydroxy APA to Trypanosoma brucei using the melamine motif.Pharmacological validation of Trypanosoma brucei phosphodiesterases as novel drug targets.Interaction of monobenzamidine-linked trypanocides with the Trypanosoma brucei P2 aminopurine transporterGenetic dissection of drug resistance in trypanosomesEstablishment of ATP-based luciferase viability assay in 96-well plate for Trypanosoma congolense.Trypanocidal furamidine analogues: influence of pyridine nitrogens on trypanocidal activity, transport kinetics, and resistance patterns.Understanding mixed sequence DNA recognition by novel designed compounds: the kinetic and thermodynamic behavior of azabenzimidazole diamidinesThe diamidine diminazene aceturate is a substrate for the high-affinity pentamidine transporter: implications for the development of high resistance levels in trypanosomesNutrient transport and pathogenesis in selected parasitic protozoa.A new nonpolar N-hydroxy imidazoline lead compound with improved activity in a murine model of late-stage Trypanosoma brucei brucei infection is not cross-resistant with diamidines.Buparvaquone is active against Neospora caninum in vitro and in experimentally infected mice.Antitrypanosomal activity of fexinidazole, a new oral nitroimidazole drug candidate for treatment of sleeping sicknessChimerization at the AQP2-AQP3 locus is the genetic basis of melarsoprol-pentamidine cross-resistance in clinical Trypanosoma brucei gambiense isolates.Nucleoside and nucleobase transporters in parasitic protozoa.Mitochondrial DNA sequence divergence and diversity of Glossina fuscipes fuscipes in the Lake Victoria basin of Uganda: implications for control.Aquaglyceroporin 2 controls susceptibility to melarsoprol and pentamidine in African trypanosomesThe Role of Folate Transport in Antifolate Drug Action in Trypanosoma brucei.Targeting the parasite's DNA with methyltriazenyl purine analogs is a safe, selective, and efficacious antitrypanosomal strategyPurine and pyrimidine transport in pathogenic protozoa: from biology to therapy.Aromatic diamidines as antiparasitic agents.
P2860
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P2860
Mechanisms of arsenical and diamidine uptake and resistance in Trypanosoma brucei.
description
2003 nî lūn-bûn
@nan
2003年の論文
@ja
2003年学术文章
@wuu
2003年学术文章
@zh-cn
2003年学术文章
@zh-hans
2003年学术文章
@zh-my
2003年学术文章
@zh-sg
2003年學術文章
@yue
2003年學術文章
@zh
2003年學術文章
@zh-hant
name
Mechanisms of arsenical and diamidine uptake and resistance in Trypanosoma brucei.
@ast
Mechanisms of arsenical and diamidine uptake and resistance in Trypanosoma brucei.
@en
type
label
Mechanisms of arsenical and diamidine uptake and resistance in Trypanosoma brucei.
@ast
Mechanisms of arsenical and diamidine uptake and resistance in Trypanosoma brucei.
@en
prefLabel
Mechanisms of arsenical and diamidine uptake and resistance in Trypanosoma brucei.
@ast
Mechanisms of arsenical and diamidine uptake and resistance in Trypanosoma brucei.
@en
P2093
P2860
P50
P1433
P1476
Mechanisms of arsenical and diamidine uptake and resistance in Trypanosoma brucei.
@en
P2093
Federico Geiser
John C K Enyaru
Lynsey J M Wallace
Mhairi L Stewart
Michael P Barrett
Ronald Kaminsky
Thomas Seebeck
P2860
P304
P356
10.1128/EC.2.5.1003-1008.2003
P577
2003-10-01T00:00:00Z