Vaccination with minigenes encoding V(H)-derived major histocompatibility complex class I-binding epitopes activates cytotoxic T cells that ablate autoantibody-producing B cells and inhibit lupus.
about
Genes, tolerance and systemic autoimmunityHomeostatic regulation of marginal zone B cells by invariant natural killer T cells.Pathogenic and Epiphenomenal Anti-DNA Antibodies in SLE.Invariant NKT cells inhibit autoreactive B cells in a contact- and CD1d-dependent manner.Vectors for the treatment of autoimmune disease.Therapeutic potential of CD8+ cytotoxic T lymphocytes in SLEGene therapy for autoimmune diseases: quo vadis?Disparate effects of depletion of CD1d-reactive T cells during early versus late stages of disease in a genetically susceptible model of lupus.Brief treatment with iNKT cell ligand α-galactosylceramide confers a long-term protection against lupus.Cellular and molecular mechanisms of regulation of autoantibody production in lupus.SLE: translating lessons from model systems to human diseaseAn ACE inhibitor reduces Th2 cytokines and TGF-beta1 and TGF-beta2 isoforms in murine lupus nephritis.The natural killer T cell ligand alpha-galactosylceramide prevents or promotes pristane-induced lupus in miceCD1d deficiency exacerbates inflammatory dermatitis in MRL-lpr/lpr mice.Differences between CD8+ T cells in lupus-prone (NZB x NZW) F1 mice and healthy (BALB/c x NZW) F1 mice may influence autoimmunity in the lupus model.Dual roles of immunoregulatory cytokine TGF-beta in the pathogenesis of autoimmunity-mediated organ damageExamining the role of CD1d and natural killer T cells in the development of nephritis in a genetically susceptible lupus modelA female preponderance for chemically induced lupus in SJL/J mice.Differential contribution of IL-4 and STAT6 vs STAT4 to the development of lupus nephritis.A role for sex chromosome complement in the female bias in autoimmune disease.In vivo maturation of allo-specific CD8 CTL and prevention of lupus-like graft-versus-host disease is critically dependent on T cell signaling through the TNF p75 receptor but not the TNF p55 receptor.Germline deletion of β2 microglobulin or CD1d reduces anti-phospholipid antibody, but increases autoantibodies against non-phospholipid antigens in the NZB/W F1 model of lupusDevelopment of biologicals for the therapy of lupus erythematosus.CTL-promoting effects of CD40 stimulation outweigh B cell-stimulatory effects resulting in B cell elimination and disease improvement in a murine model of lupus.Fas expression on antigen-specific T cells has costimulatory, helper, and down-regulatory functions in vivo for cytotoxic T cell responses but not for T cell-dependent B cell responses.
P2860
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P2860
Vaccination with minigenes encoding V(H)-derived major histocompatibility complex class I-binding epitopes activates cytotoxic T cells that ablate autoantibody-producing B cells and inhibit lupus.
description
2002 nî lūn-bûn
@nan
2002年の論文
@ja
2002年学术文章
@wuu
2002年学术文章
@zh-cn
2002年学术文章
@zh-hans
2002年学术文章
@zh-my
2002年学术文章
@zh-sg
2002年學術文章
@yue
2002年學術文章
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2002年學術文章
@zh-hant
name
Vaccination with minigenes enc ...... ing B cells and inhibit lupus.
@ast
Vaccination with minigenes enc ...... ing B cells and inhibit lupus.
@en
type
label
Vaccination with minigenes enc ...... ing B cells and inhibit lupus.
@ast
Vaccination with minigenes enc ...... ing B cells and inhibit lupus.
@en
prefLabel
Vaccination with minigenes enc ...... ing B cells and inhibit lupus.
@ast
Vaccination with minigenes enc ...... ing B cells and inhibit lupus.
@en
P2860
P356
P1476
Vaccination with minigenes enc ...... ing B cells and inhibit lupus.
@en
P2093
Guo-Chang Fan
Ram Raj Singh
P2860
P304
P356
10.1084/JEM.20020223
P407
P577
2002-09-01T00:00:00Z