Physiological beta cell death triggers priming of self-reactive T cells by dendritic cells in a type-1 diabetes model. - Wikidata - wikimedia - TriplyDB

Physiological beta cell death triggers priming of self-reactive T cells by dendritic cells in a type-1 diabetes model.

Physiological beta cell death triggers priming of self-reactive T cells by dendritic cells in a type-1 diabetes model.

http://www.wikidata.org/entity/Q36371477

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Central role of defective interleukin-2 production in the triggering of islet autoimmune destruction Interleukin-1 stimulates beta-cell necrosis and release of the immunological adjuvant HMGB1 Human leukocyte Antigen-DM polymorphisms in autoimmune diseases The Role of the Immune Response in Chlamydia trachomatis Infection of the Male Genital Tract: A Double-Edged Sword Treatment of autoimmune diabetes by inhibiting the initial event A novel CD93 polymorphism in non-obese diabetic (NOD) and NZB/W F1 mice is linked to a CD4+ iNKT cell deficient state Genetics, pathogenesis and clinical interventions in type 1 diabetes Apoptosis of NOD.H2 h4 thyrocytes by low concentrations of iodide is associated with impaired control of oxidative stress Where CD4+CD25+ T reg cells impinge on autoimmune diabetes How dying cells alert the immune system to danger The role of dendritic cells in autoimmunity Resolving the conundrum of islet transplantation by linking metabolic dysregulation, inflammation, and immune regulation.Dendritic cells in islets of Langerhans constitutively present beta cell-derived peptides bound to their class II MHC molecules Real-time immune cell interactions in target tissue during autoimmune-induced damage and graft tolerance.An evolving autoimmune microenvironment regulates the quality of effector T cell restimulation and function RIPK1 and NF-κB signaling in dying cells determines cross-priming of CD8⁺ T cells.Making antigen invisible: a coinhibitory molecule regulates the interaction between T cells and dendritic cells.Transgenic expression of Hsc70 in pancreatic islets enhances autoimmune diabetes in response to beta cell damage Targeted regulation of self-peptide presentation prevents type I diabetes in mice without disrupting general immunocompetence.The pathogenicity of self-antigen decreases at high levels of autoantigenicity: a computational approach.The central role of antigen presentation in islets of Langerhans in autoimmune diabetes Cathepsin L is essential for onset of autoimmune diabetes in NOD mice.Role of innate immunity in the pathogenesis of type 1 and type 2 diabetes.Cutting edge: merocytic dendritic cells break T cell tolerance to beta cell antigens in nonobese diabetic mouse diabetes.Alpha4beta7 integrin/MAdCAM-1 adhesion pathway is crucial for B cell migration into pancreatic lymph nodes in nonobese diabetic mice The role of TNF-alpha in the pathogenesis of type 1 diabetes in the nonobese diabetic mouse: analysis of dendritic cell maturation Macrophages and β-cells are responsible for CXCR2-mediated neutrophil infiltration of the pancreas during autoimmune diabetes MicroRNA-29b modulates innate and antigen-specific immune responses in mouse models of autoimmunity Endocrine self and gut non-self intersect in the pancreatic lymph nodes Congenic mesenchymal stem cell therapy reverses hyperglycemia in experimental type 1 diabetes.Membrane repair and immunological danger.Novel role for matricellular proteins in the regulation of islet β cell survival: the effect of SPARC on survival, proliferation, and signaling.Amplification of autoimmune response through induction of dendritic cell maturation in inflamed tissues.Annexin A1 on the surface of early apoptotic cells suppresses CD8+ T cell immunity.The inflammatory response to cell death.Impaired thymic tolerance to α-myosin directs autoimmunity to the heart in mice and humans A missing PD-L1/PD-1 coinhibition regulates diabetes induction by preproinsulin-specific CD8 T-cells in an epitope-specific manner Role of innate immunity in diabetes and metabolism: recent progress in the study of inflammasomes.CCR7 directs the recruitment of T cells into inflamed pancreatic islets of nonobese diabetic (NOD) mice.Proteasome immunosubunits protect against the development of CD8 T cell-mediated autoimmune diseases

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P2860

Physiological beta cell death triggers priming of self-reactive T cells by dendritic cells in a type-1 diabetes model.

http://www.wikidata.org/entity/Q36371477

description

2003 nî lūn-bûn

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2003年学术文章

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2003年學術文章

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Physiological beta cell death ...... ls in a type-1 diabetes model.

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Physiological beta cell death ...... ls in a type-1 diabetes model.

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Journal of Experimental Medicine

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Physiological beta cell death ...... ls in a type-1 diabetes model.

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Christophe Benoist

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Diane Mathis

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Laurent Poirot

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Masakazu Hattori

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Shannon Turley

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P2860

Caspase-12 mediates endoplasmic-reticulum-specific apoptosis and cytotoxicity by amyloid-beta

Dendritic cells: specialized and regulated antigen processing machines

Mechanisms of phagocytosis in macrophages

Identification of MHC class II-restricted peptide ligands, including a glutamic acid decarboxylase 65 sequence, that stimulate diabetogenic T cells from transgenic BDC2.5 nonobese diabetic mice.

Neonatal beta-cell apoptosis: a trigger for autoimmune diabetes?

CD8(+) but not CD8(-) dendritic cells cross-prime cytotoxic T cells in vivo.

Blockade of caspases inhibits amebic liver abscess formation in a mouse model of disease.

In vivo activation of antigen-specific CD4 T cells.

Autoimmunity provoked by infection: how good is the case for T cell epitope mimicry?

beta-Cell death during progression to diabetes.

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14623908

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type-1 diabetes

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2194112

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