Corallopyronin A specifically targets and depletes essential obligate Wolbachia endobacteria from filarial nematodes in vivo.

Corallopyronin A specifically targets and depletes essential obligate Wolbachia endobacteria from filarial nematodes in vivo.

Item
http://www.wikidata.org/entity/Q36376200
Biosynthesis of α-pyronesRepurposing of approved drugs from the human pharmacopoeia to target Wolbachia endosymbionts of onchocerciasis and lymphatic filariasis.Development of patent Litomosoides sigmodontis infections in semi-susceptible C57BL/6 mice in the absence of adaptive immune responses.Efficacy of three-week oxytetracycline or rifampin monotherapy compared with a combination regimen against the filarial nematode Onchocerca ochengiIntegrated transcriptomic and proteomic analysis of the global response of Wolbachia to doxycycline-induced stress.Antibiotics from myxobacteria.Biosynthesis of polyketides by trans-AT polyketide synthases.Toolbox for Antibiotics Discovery from Microorganisms.Natural products from myxobacteria: novel metabolites and bioactivities.Structural basis of head to head polyketide fusion by CorB.Function of the loading module in CorI and of the O-methyltransferase CorH in vinyl carbamate biosynthesis of the antibiotic corallopyronin A.Salimyxins and enhygrolides: antibiotic, sponge-related metabolites from the obligate marine myxobacterium Enhygromyxa salina.Enhanced production of undecylprodigiosin in Streptomyces coelicolor by co-cultivation with the corallopyronin A-producing myxobacterium, Corallococcus coralloides.Orientia tsutsugamushi is highly susceptible to the RNA polymerase switch region inhibitor Corallopyronin A in vitro and in vivo.Combinations of registered drugs reduce treatment times required to deplete Wolbachia in the Litomosoides sigmodontis mouse model.
P2860

Corallopyronin A specifically targets and depletes essential obligate Wolbachia endobacteria from filarial nematodes in vivo.

Item
http://www.wikidata.org/entity/Q36376200
description
2012 nî lūn-bûn
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2012年学术文章
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name
Corallopyronin A specifically ...... om filarial nematodes in vivo.
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Corallopyronin A specifically ...... om filarial nematodes in vivo.
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type
label
Corallopyronin A specifically ...... om filarial nematodes in vivo.
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Corallopyronin A specifically ...... om filarial nematodes in vivo.
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prefLabel
Corallopyronin A specifically ...... om filarial nematodes in vivo.
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Corallopyronin A specifically ...... om filarial nematodes in vivo.
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P1433
P1476
P2093
P2860
P304
P31
P356
P407
P433
P478
P50
P577
P5875
P698
P921
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P1476
Corallopyronin A specifically ...... om filarial nematodes in vivo.
@en
P2093
P2860
P304
P31
P356
P407
P433
P478
P50
P577
P5875
P698
P921
P932