Global identification of MLL2-targeted loci reveals MLL2's role in diverse signaling pathways
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SET1 and p300 act synergistically, through coupled histone modifications, in transcriptional activation by p53Mutation of chromatin modifiers; an emerging hallmark of germinal center B-cell lymphomasRecent progress toward epigenetic therapies: the example of mixed lineage leukemiaMendelian disorders of the epigenetic machinery: tipping the balance of chromatin statesHijacked in cancer: the KMT2 (MLL) family of methyltransferasesInterplay between genomic alterations and androgen receptor signaling during prostate cancer development and progressionA Review of the Scaffold Protein Menin and its Role in Hepatobiliary Pathology.Molecular markers of paragangliomas/pheochromocytomasClinico-pathological description of three paediatric medulloblastoma cases with MLL2/3 gene mutations.KMT2D maintains neoplastic cell proliferation and global histone H3 lysine 4 monomethylation.H3K4 mono- and di-methyltransferase MLL4 is required for enhancer activation during cell differentiation.Disruption of KMT2D perturbs germinal center B cell development and promotes lymphomagenesis.RNA-Seq and ChIP-Seq reveal SQSTM1/p62 as a key mediator of JunB suppression of NF-κB-dependent inflammationS100 proteins in cancer.Histone deacetylase inhibition rescues structural and functional brain deficits in a mouse model of Kabuki syndrome.Kabuki syndrome genes KMT2D and KDM6A: functional analyses demonstrate critical roles in craniofacial, heart and brain development.An in vivo molecular response analysis of colorectal cancer treated with Astragalus membranaceus extractTargeted next-generation sequencing reveals high frequency of mutations in epigenetic regulators across treatment-naïve patient melanomas.An Epigenetic Pathway Regulates Sensitivity of Breast Cancer Cells to HER2 Inhibition via FOXO/c-Myc AxisThe necessity for in vivo functional analysis in human medical genetics.Epigenetics, autism spectrum, and neurodevelopmental disorders.The MLL3/MLL4 branches of the COMPASS family function as major histone H3K4 monomethylases at enhancers.Integrative analysis of two cell lines derived from a non-small-lung cancer patient--a panomics approach.SET for life: biochemical activities and biological functions of SET domain-containing proteinsExome sequencing identifies frequent mutation of MLL2 in non-small cell lung carcinoma from Chinese patients.Molecular lesions in B-cell lymphoproliferative disorders: recent contributions from studies utilizing high-throughput sequencing techniques.Progress against follicular lymphomaMolecular aberrations, targeted therapy, and renal cell carcinoma: current state-of-the-art.Mutation of cancer driver MLL2 results in transcription stress and genome instability.A-kinase anchoring protein AKAP95 is a novel regulator of ribosomal RNA synthesis.Evolving Catalytic Properties of the MLL Family SET Domain.Defects of B-cell terminal differentiation in patients with type-1 Kabuki syndrome.Colorectal cancer risk and patients' survival: influence of polymorphisms in genes somatically mutated in colorectal tumors.Cic Loss Promotes Gliomagenesis via Aberrant Neural Stem Cell Proliferation and Differentiation.Patients with a Kabuki syndrome phenotype demonstrate DNA methylation abnormalities.Interaction between STAT3 and GLI1/tGLI1 oncogenic transcription factors promotes the aggressiveness of triple-negative breast cancers and HER2-enriched breast cancer.The defining DNA methylation signature of Kabuki syndrome enables functional assessment of genetic variants of unknown clinical significance.MLL2/KMT2D and MLL3/KMT2C expression correlates with disease progression and response to imatinib mesylate in chronic myeloid leukemia.Modes of Interaction of KMT2 Histone H3 Lysine 4 Methyltransferase/COMPASS Complexes with Chromatin.Mutant allele quantification reveals a genetic basis for TP53 mutation-driven castration resistance in prostate cancer cells
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P2860
Global identification of MLL2-targeted loci reveals MLL2's role in diverse signaling pathways
description
2012 nî lūn-bûn
@nan
2012年の論文
@ja
2012年学术文章
@wuu
2012年学术文章
@zh-cn
2012年学术文章
@zh-hans
2012年学术文章
@zh-my
2012年学术文章
@zh-sg
2012年學術文章
@yue
2012年學術文章
@zh
2012年學術文章
@zh-hant
name
Global identification of MLL2- ...... in diverse signaling pathways
@ast
Global identification of MLL2- ...... in diverse signaling pathways
@en
type
label
Global identification of MLL2- ...... in diverse signaling pathways
@ast
Global identification of MLL2- ...... in diverse signaling pathways
@en
prefLabel
Global identification of MLL2- ...... in diverse signaling pathways
@ast
Global identification of MLL2- ...... in diverse signaling pathways
@en
P2093
P2860
P50
P356
P1476
Global identification of MLL2- ...... in diverse signaling pathways
@en
P2093
Changcun Guo
Chun-Chi Chang
Dawn N Kernagis
Gerald A Grant
Jen-Tsan Chi
Lee H Chen
Matthew Wortham
Nickolas Papadopoulos
Xiaoxia Qin
P2860
P304
17603-17608
P356
10.1073/PNAS.1208807109
P407
P577
2012-10-08T00:00:00Z