Targeting of Nrf2 induces DNA damage signaling and protects colonic epithelial cells from ionizing radiation. - Wikidata - wikimedia - TriplyDB

Targeting of Nrf2 induces DNA damage signaling and protects colonic epithelial cells from ionizing radiation.

Targeting of Nrf2 induces DNA damage signaling and protects colonic epithelial cells from ionizing radiation.

http://www.wikidata.org/entity/Q36378414

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Concerted action of Nrf2-ARE pathway, MRN complex, HMGB1 and inflammatory cytokines - implication in modification of radiation damage Transcription Factors in the Cellular Response to Charged Particle Exposure Oxidative stress and autophagy: the clash between damage and metabolic needs The Nrf2-inducers tanshinone I and dihydrotanshinone protect human skin cells and reconstructed human skin against solar simulated UV CDDO-Me protects normal lung and breast epithelial cells but not cancer cells from radiation Bromodomain and extraterminal proteins suppress NF-E2-related factor 2-mediated antioxidant gene expression.Ginger compound [6]-shogaol and its cysteine-conjugated metabolite (M2) activate Nrf2 in colon epithelial cells in vitro and in vivo Bardoxolone methyl (CDDO-Me) as a therapeutic agent: an update on its pharmacokinetic and pharmacodynamic properties.Radiation protection of the gastrointestinal tract and growth inhibition of prostate cancer xenografts by a single compound.Targeted inhibition of histone deacetylases and hedgehog signaling suppress tumor growth and homologous recombination in aerodigestive cancers.Therapeutic effects of C-28 methyl ester of 2-cyano-3,12-dioxoolean-1,9-dien-28-oic acid (CDDO-Me; bardoxolone methyl) on radiation-induced lung inflammation and fibrosis in mice.β2-spectrin depletion impairs DNA damage repair Effects of Local Heart Irradiation in a Glutathione S-Transferase Alpha 4-Null Mouse Model Bardoxolone Methyl Prevents High-Fat Diet-Induced Colon Inflammation in Mice.Radiation promotes colorectal cancer initiation and progression by inducing senescence-associated inflammatory responses.Brusatol Enhances the Radiosensitivity of A549 Cells by Promoting ROS Production and Enhancing DNA Damage β-Arrestin-2 modulates radiation-induced intestinal crypt progenitor/stem cell injury.NRF2-mediated Notch pathway activation enhances hematopoietic reconstitution following myelosuppressive radiation.NRF2 mitigates radiation-induced hematopoietic death Increase in the radioresistance of normal skin fibroblasts but not tumor cells by mechanical injury.Radioprotection of normal tissue cells.Nrf2 promotes survival following exposure to ionizing radiation.NRF2/miR-140 signaling confers radioprotection to human lung fibroblasts Radioresistance of bone marrow stromal and hematopoietic progenitor cell lines derived from Nrf2-/- homozygous deletion recombinant-negative mice Loss of Nrf2 promotes alveolar type 2 cell loss in irradiated, fibrotic lung.Co-Activation of PKC-δ by CRIF1 Modulates Oxidative Stress in Bone Marrow Multipotent Mesenchymal Stromal Cells after Irradiation by Phosphorylating NRF2 Ser40.Nrf2-Knockout Protects from Intestinal Injuries in C57BL/6J Mice Following Abdominal Irradiation with γ Rays.The loss of ATP2C1 impairs the DNA damage response and induces altered skin homeostasis: Consequences for epidermal biology in Hailey-Hailey disease.Histone acetyltransferase KAT8 is essential for mouse oocyte development by regulating reactive oxygen species levels.Ginger Oleoresin Alleviated γ-Ray Irradiation-Induced Reactive Oxygen Species via the Nrf2 Protective Response in Human Mesenchymal Stem Cells.A mitohormetic response to pro-oxidant exposure in the house mouse.Proteome Stability as a Key Factor of Genome Integrity.Amplification of F-Actin Disassembly and Cellular Repulsion by Growth Factor Signaling.Camptothecin induces G2/M phase arrest through the ATM-Chk2-Cdc25C axis as a result of autophagy-induced cytoprotection: Implications of reactive oxygen species.

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Targeting of Nrf2 induces DNA damage signaling and protects colonic epithelial cells from ionizing radiation.

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PNAS.1207718109

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Proceedings of the National Academy of Sciences of the United States of America

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Aadil Kaisani

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Crystal Cornelius

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Jerry W Shay

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Raj K Pandita

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Sang Bum Kim

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Ugur Eskiocak

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Involvement of human MOF in ATM function

Sister chromatids are preferred over homologs as substrates for recombinational repair in Saccharomyces cerevisiae

Neuroprotective effect of Nrf2/ARE activators, CDDO ethylamide and CDDO trifluoroethylamide, in a mouse model of amyotrophic lateral sclerosis

Human heterochromatin protein 1 isoforms HP1(Hsalpha) and HP1(Hsbeta) interfere with hTERT-telomere interactions and correlate with changes in cell growth and response to ionizing radiation

RAD51 localization and activation following DNA damage

Catalysis of ATP-dependent homologous DNA pairing and strand exchange by yeast RAD51 protein.

Regulation of hormone-induced histone hyperacetylation and gene activation via acetylation of an acetylase

An Nrf2/small Maf heterodimer mediates the induction of phase II detoxifying enzyme genes through antioxidant response elements

The mechanism of human nonhomologous DNA end joining

Molecular mechanisms of mammalian DNA repair and the DNA damage checkpoints

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Woodring E. Wright

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2012-10-08T00:00:00Z

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