Molecular mechanisms of mammalian DNA repair and the DNA damage checkpoints
about
Multiple ATR-Chk1 pathway proteins preferentially associate with checkpoint-inducing DNA substratesFumarase: a mitochondrial metabolic enzyme and a cytosolic/nuclear component of the DNA damage responseCentrosome-associated regulators of the G(2)/M checkpoint as targets for cancer therapyNew insights into cell cycle control from the Drosophila endocycleHuman INO80 chromatin-remodelling complex contributes to DNA double-strand break repair via the expression of Rad54B and XRCC3 genesRAD18-BRCTx interaction is required for efficient repair of UV-induced DNA damageInduction of p19INK4d in response to ultraviolet light improves DNA repair and confers resistance to apoptosis in neuroblastoma cellsCdk5 activator-binding protein C53 regulates apoptosis induced by genotoxic stress via modulating the G2/M DNA damage checkpointCoupling of human circadian and cell cycles by the timeless protein.TAO kinases mediate activation of p38 in response to DNA damageThe human checkpoint sensor and alternative DNA clamp Rad9-Rad1-Hus1 modulates the activity of DNA ligase I, a component of the long-patch base excision repair machineryThe human Rad9 checkpoint protein stimulates the carbamoyl phosphate synthetase activity of the multifunctional protein CADCircadian control of XPA and excision repair of cisplatin-DNA damage by cryptochrome and HERC2 ubiquitin ligaseMenin stimulates homology-directed DNA repairHuman PTIP facilitates ATM-mediated activation of p53 and promotes cellular resistance to ionizing radiationP90 RSK arranges Chk1 in the nucleus for monitoring of genomic integrity during cell proliferationA mouse model uncovers LKB1 as an UVB-induced DNA damage sensor mediating CDKN1A (p21WAF1/CIP1) degradationThe DNA damage pathway regulates innate immune system ligands of the NKG2D receptorProteolysis of Rad17 by Cdh1/APC regulates checkpoint termination and recovery from genotoxic stressChk2-dependent phosphorylation of XRCC1 in the DNA damage response promotes base excision repairDNA-PK-dependent RPA2 hyperphosphorylation facilitates DNA repair and suppresses sister chromatid exchangeTumor suppressor protein C53 antagonizes checkpoint kinases to promote cyclin-dependent kinase 1 activationRegulated degradation of replication-dependent histone mRNAs requires both ATR and Upf1Accumulation of Pax2 transactivation domain interaction protein (PTIP) at sites of DNA breaks via RNF8-dependent pathway is required for cell survival after DNA damageHuman Tim/Timeless-interacting protein, Tipin, is required for efficient progression of S phase and DNA replication checkpointTip60 and p400 are both required for UV-induced apoptosis but play antagonistic roles in cell cycle progression.The cohesin complex is required for the DNA damage-induced G2/M checkpoint in mammalian cellsKnockdown of SLBP results in nuclear retention of histone mRNACCDC98 targets BRCA1 to DNA damage sitesgamma-H2AX formation in response to interstrand crosslinks requires XPF in human cellsAn alternative form of replication protein a expressed in normal human tissues supports DNA repairThe role of the human SWI5-MEI5 complex in homologous recombination repairDNA damage-induced phosphorylation of MdmX at serine 367 activates p53 by targeting MdmX for Mdm2-dependent degradation.PPM1D dephosphorylates Chk1 and p53 and abrogates cell cycle checkpointsHuman MMS21/NSE2 is a SUMO ligase required for DNA repairhMOF histone acetyltransferase is required for histone H4 lysine 16 acetylation in mammalian cellsPreferential localization of hyperphosphorylated replication protein A to double-strand break repair and checkpoint complexes upon DNA damageHaploinsufficiency of the Mus81-Eme1 endonuclease activates the intra-S-phase and G2/M checkpoints and promotes rereplication in human cellsSUMO modification of human XRCC4 regulates its localization and function in DNA double-strand break repair.Characterization of functional domains in human Claspin
P2860
Q21076125-ED496A2C-1D72-41F4-817C-5467E715542EQ21145799-C2D31DEF-52FA-454C-87C1-7D7559B7701FQ21245716-C4717D23-5F02-4CAB-ACA4-C9878665EB41Q22121977-2A76E449-4EE7-4809-9259-65147858B6ABQ24294507-CC2B91C9-D1F2-4CCA-806B-ECAFC923535FQ24294922-B00CDE88-3E9C-4765-9992-6F632C324BCFQ24297524-A680ECBE-DEA1-4B58-9BED-3B7F260CF43AQ24298740-1248840D-A147-4B7F-BCEE-4C3872E1D78FQ24299164-D4A7D563-FD62-4A00-97D8-7F82C605A8CAQ24301324-3CD529B7-F5DA-4D1B-B578-B0A89C11D7CAQ24301431-7965A6E7-ACEA-4543-9557-792F8DFA92DBQ24301815-C1171BEC-28D8-43D9-B298-3A801D88F489Q24304122-BFB03193-6D48-45FB-85AA-07A428727F55Q24304240-14762BB6-8668-4FCE-B874-3DA6B3F16FABQ24305756-E40DEBE2-FC51-4E5B-BF0D-51CE79E3CCADQ24305925-856CFC88-18A1-4039-ABD8-17AD2B74E159Q24306061-95774F58-77DC-4E49-8254-79C731573764Q24306696-2C691416-99A3-4F70-84AD-2158717FF6DBQ24307983-FB508D66-906C-43E4-BD6B-8A43A6F0A8C6Q24310231-0E993457-A88E-46DA-BC3D-33F075E8F7A9Q24311527-BF86CBE6-273D-4CE0-9356-467EBEDB5CBEQ24311887-32FD9F43-E4C1-4C21-B0E3-E4C56493CCE0Q24313451-508FFCFB-8E0C-4C36-846D-970E0CFF85B2Q24313476-EA8E6F43-CCB8-44F4-AE44-4C8986A270E6Q24315071-6E8E1D78-B8DE-4E88-B247-285BA3D89FF4Q24315714-C4573FD8-9596-4630-9441-BAC47D6F87F9Q24317260-78BC5658-010A-4AD7-9951-28F95D6895AEQ24318762-B139F589-7E03-4BE1-A70E-A6398B2B9448Q24321418-834A52D2-9656-460E-A3CE-7EFB1BDC7B3AQ24329172-CC393975-7C57-4ACD-89A5-A1C141757D86Q24336962-C2C9127E-8DA1-42F9-BA5D-101994B458B6Q24337776-EC675011-EE73-4691-9506-2CDE22C21EB2Q24338364-88D2073E-1119-45D1-8020-B3BD8A28A596Q24527393-F7F92A95-D913-4355-916C-7EF8FAD9B5BCQ24529887-23832148-CA96-4600-88C6-2B22586B1E90Q24529984-2C3DFB4B-6AA2-483D-B237-62A30AE8E9CEQ24537139-905F0554-50B3-4727-9DD7-31DABA90E6F9Q24537482-126E87F6-A857-4414-A775-1F8157062204Q24548010-8554B7EC-7BE0-4560-916A-2CAD7CBA4E2AQ24601538-AC90D67B-C55A-4CB9-A987-4F1699EC4B8F
P2860
Molecular mechanisms of mammalian DNA repair and the DNA damage checkpoints
description
2004 nî lūn-bûn
@nan
2004 թուականին հրատարակուած գիտական յօդուած
@hyw
2004 թվականին հրատարակված գիտական հոդված
@hy
2004年の論文
@ja
2004年論文
@yue
2004年論文
@zh-hant
2004年論文
@zh-hk
2004年論文
@zh-mo
2004年論文
@zh-tw
2004年论文
@wuu
name
Molecular mechanisms of mammalian DNA repair and the DNA damage checkpoints
@ast
Molecular mechanisms of mammalian DNA repair and the DNA damage checkpoints
@en
Molecular mechanisms of mammalian DNA repair and the DNA damage checkpoints
@nl
type
label
Molecular mechanisms of mammalian DNA repair and the DNA damage checkpoints
@ast
Molecular mechanisms of mammalian DNA repair and the DNA damage checkpoints
@en
Molecular mechanisms of mammalian DNA repair and the DNA damage checkpoints
@nl
prefLabel
Molecular mechanisms of mammalian DNA repair and the DNA damage checkpoints
@ast
Molecular mechanisms of mammalian DNA repair and the DNA damage checkpoints
@en
Molecular mechanisms of mammalian DNA repair and the DNA damage checkpoints
@nl
P2093
P3181
P1476
Molecular mechanisms of mammalian DNA repair and the DNA damage checkpoints
@en
P2093
Keziban Unsal-Kaçmaz
Laura A Lindsey-Boltz
Stuart Linn
P3181
P356
10.1146/ANNUREV.BIOCHEM.73.011303.073723
P407
P50
P577
2004-01-01T00:00:00Z