HIV coreceptor downregulation as antiviral principle: SDF-1alpha-dependent internalization of the chemokine receptor CXCR4 contributes to inhibition of HIV replication. - Wikidata - wikimedia - TriplyDB

HIV coreceptor downregulation as antiviral principle: SDF-1alpha-dependent internalization of the chemokine receptor CXCR4 contributes to inhibition of HIV replication.

HIV coreceptor downregulation as antiviral principle: SDF-1alpha-dependent internalization of the chemokine receptor CXCR4 contributes to inhibition of HIV replication.

http://www.wikidata.org/entity/Q36380324

about

Trafficking of the HIV coreceptor CXCR4. Role of arrestins and identification of residues in the c-terminal tail that mediate receptor internalization Interleukin-8 stimulates human immunodeficiency virus type 1 replication and is a potential new target for antiretroviral therapy The chemokine receptor CCR1 is constitutively active, which leads to G protein-independent, β-arrestin-mediated internalization Binding of human immunodeficiency virus type 1 to CD4 and CXCR4 receptors differentially regulates expression of inflammatory genes and activates the MEK/ERK signaling pathway.Leukocyte analysis from WHIM syndrome patients reveals a pivotal role for GRK3 in CXCR4 signaling Chemokines regulate hippocampal neuronal signaling and gp120 neurotoxicity Anti-HIV agent trichosanthin enhances the capabilities of chemokines to stimulate chemotaxis and G protein activation, and this is mediated through interaction of trichosanthin and chemokine receptors Spontaneous and antigen-induced production of HIV-inhibitory beta-chemokines are associated with AIDS-free status Follicular B helper T cells express CXC chemokine receptor 5, localize to B cell follicles, and support immunoglobulin production SDF-1/CXCL12: A Chemokine in the Life Cycle of HIV CXCR7 functions as a scavenger for CXCL12 and CXCL11 Structural and functional studies of the potent anti-HIV chemokine variant P2-RANTES Concise Review: CXCR4/CXCL12 Signaling in Immature Hematopoiesis--Lessons From Pharmacological and Genetic Models Comodulation of CXCR4 and CD26 in human lymphocytes The influence of CD4 and CXCR4 on maedi-visna virus-induced syncytium formation Structure-function relationship between the human chemokine receptor CXCR3 and its ligands Genomic organization and promoter characterization of human CXCR4 gene Inhibitory mechanism of the CXCR4 antagonist T22 against human immunodeficiency virus type 1 infection.Duration of sample storage dramatically alters expression of the human immunodeficiency virus coreceptors CXCR4 and CCR5 Human alpha1-acid glycoprotein binds to CCR5 expressed on the plasma membrane of human primary macrophages HIV-1, methamphetamine and astrocytes at neuroinflammatory Crossroads CXCL12 activation of CXCR4 regulates mucosal host defense through stimulation of epithelial cell migration and promotion of intestinal barrier integrity Human immunodeficiency virus (HIV) envelope binds to CXCR4 independently of CD4, and binding can be enhanced by interaction with soluble CD4 or by HIV envelope deglycosylation.The biology of CCR5 and CXCR4 Site-specific phosphorylation of CXCR4 is dynamically regulated by multiple kinases and results in differential modulation of CXCR4 signaling.Cell migration to CXCL12 requires simultaneous IKKα and IKKβ-dependent NF-κB signaling Multiple active states and oligomerization of CCR5 revealed by functional properties of monoclonal antibodies.Processing, stability, and receptor binding properties of oligomeric envelope glycoprotein from a primary HIV-1 isolate.Human immunodeficiency virus type 1 entry inhibitors selected on living cells from a library of phage chemokines.Optimal inhibition of X4 HIV isolates by the CXC chemokine stromal cell-derived factor 1 alpha requires interaction with cell surface heparan sulfate proteoglycans.Unique ligand binding sites on CXCR4 probed by a chemical biology approach: implications for the design of selective human immunodeficiency virus type 1 inhibitors.Rapid inactivation of stromal cell-derived factor-1 by cathepsin G associated with lymphocytes.The HIV envelope but not VSV glycoprotein is capable of mediating HIV latent infection of resting CD4 T cells Chemokine coreceptor signaling in HIV-1 infection and pathogenesis.Chemokines: extracellular messengers for all occasions?The effect of route of immunization on mucosal immunity and protection.The chemokine CXCL13 is a key regulator of B cell recruitment to the cerebrospinal fluid in acute Lyme neuroborreliosis.The role of the chemokine receptor CXCR4 in infection with feline immunodeficiency virus.Opposite effects of SDF-1 on human immunodeficiency virus type 1 replication.Differential inhibition of human immunodeficiency virus type 1 fusion, gp120 binding, and CC-chemokine activity by monoclonal antibodies to CCR5

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P2860

HIV coreceptor downregulation as antiviral principle: SDF-1alpha-dependent internalization of the chemokine receptor CXCR4 contributes to inhibition of HIV replication.

http://www.wikidata.org/entity/Q36380324

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1997 nî lūn-bûn

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HIV coreceptor downregulation ...... inhibition of HIV replication.

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HIV coreceptor downregulation ...... inhibition of HIV replication.

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HIV coreceptor downregulation ...... inhibition of HIV replication.

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HIV coreceptor downregulation ...... inhibition of HIV replication.

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HIV coreceptor downregulation ...... inhibition of HIV replication.

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A Amara

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F Arenzana-Seisdedos

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J L Virelizier

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J Salamero

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M Baggiolini

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P2860

HIV-1 Entry Cofactor: Functional cDNA Cloning of a Seven-Transmembrane, G Protein-Coupled Receptor

Identification of a major co-receptor for primary isolates of HIV-1

Chemical synthesis, purification, and characterization of two inflammatory proteins, neutrophil activating peptide 1 (interleukin-8) and neutrophil activating peptide

The lymphocyte chemoattractant SDF-1 is a ligand for LESTR/fusin and blocks HIV-1 entry

Cloning of a human seven-transmembrane domain receptor, LESTR, that is highly expressed in leukocytes

A dual-tropic primary HIV-1 isolate that uses fusin and the beta-chemokine receptors CKR-5, CKR-3, and CKR-2b as fusion cofactors

Identification of RANTES, MIP-1 alpha, and MIP-1 beta as the major HIV-suppressive factors produced by CD8+ T cells

The beta-chemokine receptors CCR3 and CCR5 facilitate infection by primary HIV-1 isolates

Human immunodeficiency virus strains differ in their ability to infect CD4+ cells expressing the rat homolog of CXCR-4 (fusin)

CC CKR5: a RANTES, MIP-1alpha, MIP-1beta receptor as a fusion cofactor for macrophage-tropic HIV-1

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139-146

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1

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