Erythrocyte glutamine depletion, altered redox environment, and pulmonary hypertension in sickle cell disease. - Wikidata - wikimedia - TriplyDB

Erythrocyte glutamine depletion, altered redox environment, and pulmonary hypertension in sickle cell disease.

Erythrocyte glutamine depletion, altered redox environment, and pulmonary hypertension in sickle cell disease.

http://www.wikidata.org/entity/Q36384658

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Biomarkers and recent advances in the management and therapy of sickle cell disease Dysregulated arginine metabolism and cardiopulmonary dysfunction in patients with thalassaemia Stroke in patients with sickle cell disease.Antisickling property of fetal hemoglobin enhances nitric oxide bioavailability and ameliorates organ oxidative stress in transgenic-knockout sickle mice.microRNA miR-144 modulates oxidative stress tolerance and associates with anemia severity in sickle cell disease.Elevated pulse pressure is associated with hemolysis, proteinuria and chronic kidney disease in sickle cell disease.Peroxisome proliferator-activated receptor-α-mediated transcription of miR-199a2 attenuates endothelin-1 expression via hypoxia-inducible factor-1α Glutamine supplementation alleviates vasculopathy and corrects metabolic profile in an in vivo model of endothelial cell dysfunction Clinical assay of four thiol amino acid redox couples by LC-MS/MS: utility in thalassemia Clinical biomarkers in sickle cell disease.Role of aminotransferases in glutamate metabolism of human erythrocytes.MicroRNA 648 Targets ET-1 mRNA and is cotranscriptionally regulated with MICAL3 by PAX5.2D DIGE based proteomics study of erythrocyte cytosol in sickle cell disease: altered proteostasis and oxidative stress.Vasculopathy in sickle cell disease: Biology, pathophysiology, genetics, translational medicine, and new research directions Pleiotropic effects of intravascular haemolysis on vascular homeostasis.Glutamine supplementation in sick children: is it beneficial?Nitric oxide and arginine dysregulation: a novel pathway to pulmonary hypertension in hemolytic disorders Phase 1 Study of a Sulforaphane-Containing Broccoli Sprout Homogenate for Sickle Cell Disease Possible links between sickle cell crisis and pentavalent antimony.N-acetylcysteine reduces oxidative stress in sickle cell patients A nutrient-dense, high-fiber, fruit-based supplement bar increases HDL cholesterol, particularly large HDL, lowers homocysteine, and raises glutathione in a 2-wk trial.Nonhematopoietic Nrf2 dominantly impedes adult progression of sickle cell anemia in mice.A randomized, placebo-controlled trial of arginine therapy for the treatment of children with sickle cell disease hospitalized with vaso-occlusive pain episodes Novel small molecule therapeutics for sickle cell disease: nitric oxide, carbon monoxide, nitrite, and apolipoprotein A-I.Hematologic, biochemical, and cardiopulmonary effects of L-arginine supplementation or phosphodiesterase 5 inhibition in patients with sickle cell disease who are on hydroxyurea therapy Sickle cell anemia and vascular dysfunction: the nitric oxide connection.Oxidative stress in sickle cell disease; pathophysiology and potential implications for disease management.Biomarkers in sickle cell disease.Role of oxidative stress in the pathogenesis of sickle cell disease.Therapeutic approaches to limit hemolysis-driven endothelial dysfunction: scavenging free heme to preserve vasculature homeostasis.Emerging drugs for sickle cell anemia.Triterpenoid inducers of Nrf2 signaling as potential therapeutic agents in sickle cell disease: a review.Mortality, asthma, smoking and acute chest syndrome in young adults with sickle cell disease.A new metabolomic assay to examine inflammation and redox pathways following LPS challenge.Targeting tumor hypoxia with the epigenetic anticancer agent, RRx-001: a superagonist of nitric oxide generation.Pathophisiology of sickle cell disease and new drugs for the treatment.Saudi Guidelines on the Diagnosis and Treatment of Pulmonary Hypertension: Pulmonary hypertension associated with hemolytic anemia.The proverbial chicken or the egg? Dissection of the role of cell-free hemoglobin versus reactive oxygen species in sickle cell pathophysiology.Pulmonary hypertension in hemolytic anemias Brain neurochemical and hemodynamic findings in the NY1DD mouse model of mild sickle cell disease.

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P2860

Erythrocyte glutamine depletion, altered redox environment, and pulmonary hypertension in sickle cell disease.

http://www.wikidata.org/entity/Q36384658

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Claudia R Morris

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D Anton Bland

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Frans A Kuypers

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Jung H Suh

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P2860

The L-arginine-nitric oxide pathway

Elevated glutamine/glutamate ratio in cerebrospinal fluid of first episode and drug naive schizophrenic patients

L-glutamine therapy reduces endothelial adhesion of sickle red blood cells to human umbilical vein endothelial cells

The importance of glutathione in human disease

Free radicals, antioxidants, and nutrition

Oxidative stress and induction of heme oxygenase-1 in the kidney in sickle cell disease

Sickle cell anemia is associated with reduced nitric oxide bioactivity in peripheral conduit and resistance vessels.

Biologic and pharmacologic regulation of mammalian glutathione synthesis.

Role of oxidative stress and protein oxidation in the aging process.

The biochemistry of aging.

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1

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arterial hypertension

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