Targeting autophagy as a novel strategy for facilitating the therapeutic action of potentiators on ΔF508 cystic fibrosis transmembrane conductance regulator.
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Manipulating proteostasis to repair the F508del-CFTR defect in cystic fibrosisCFTR: a hub for kinases and crosstalk of cAMP and Ca2+Cystic fibrosis transmembrane conductance regulator modulators in cystic fibrosis: current perspectivesCFTR Modulators: Shedding Light on Precision Medicine for Cystic FibrosisDepletion of the ubiquitin-binding adaptor molecule SQSTM1/p62 from macrophages harboring cftr ΔF508 mutation improves the delivery of Burkholderia cenocepacia to the autophagic machineryThe emerging potential of autophagy-based therapies in the treatment of cystic fibrosis lung infectionsStructural stability of Burkholderia cenocepacia biofilms is reliant on eDNA structure and presence of a bacterial nucleic acid binding proteinIFN-γ stimulates autophagy-mediated clearance of Burkholderia cenocepacia in human cystic fibrosis macrophagesRescue of murine F508del CFTR activity in native intestine by low temperature and proteasome inhibitorsRadiation persistently promoted oxidative stress, activated mTOR via PI3K/Akt, and downregulated autophagy pathway in mouse intestineRestoration of CFTR function in patients with cystic fibrosis carrying the F508del-CFTR mutationPhosphoethanolamine Modification of Neisseria gonorrhoeae Lipid A Reduces Autophagy Flux in MacrophagesGender Differences in Clinical Presentations of Cystic Fibrosis Patients in Azeri Turkish PopulationTargeting the Intracellular Environment in Cystic Fibrosis: Restoring Autophagy as a Novel Strategy to Circumvent the CFTR Defect.From CFTR biology toward combinatorial pharmacotherapy: expanded classification of cystic fibrosis mutations.Disease-relevant proteostasis regulation of cystic fibrosis transmembrane conductance regulator.Reduced caveolin-1 promotes hyperinflammation due to abnormal heme oxygenase-1 localization in lipopolysaccharide-challenged macrophages with dysfunctional cystic fibrosis transmembrane conductance regulator.A novel treatment of cystic fibrosis acting on-target: cysteamine plus epigallocatechin gallate for the autophagy-dependent rescue of class II-mutated CFTRCFTR activity and mitochondrial function.MARCH2 regulates autophagy by promoting CFTR ubiquitination and degradation and PIK3CA-AKT-MTOR signalingCysteamine re-establishes the clearance of Pseudomonas aeruginosa by macrophages bearing the cystic fibrosis-relevant F508del-CFTR mutation.Autophagy in lung disease pathogenesis and therapeutics.Repairing the basic defect in cystic fibrosis - one approach is not enough.Targeting the PI3K/Akt/mTOR signalling pathway in Cystic FibrosisCystic fibrosis: current therapeutic targets and future approaches.Metabolic interactions between cysteamine and epigallocatechin gallate.Strategies in early clinical development for the treatment of basic defects of cystic fibrosis.The burgeoning field of innate immune-mediated disease and autoinflammation.Elevated Mirc1/Mir17-92 cluster expression negatively regulates autophagy and CFTR (cystic fibrosis transmembrane conductance regulator) function in CF macrophages.Cigarette smoke induced autophagy-impairment accelerates lung aging, COPD-emphysema exacerbations and pathogenesis.The holy grail of cystic fibrosis research: pharmacological repair of the F508del-CFTR mutation.Intracellular survival of Burkholderia cepacia complex in phagocytic cells.Strategies for the etiological therapy of cystic fibrosis.Cysteamine-mediated clearance of antibiotic-resistant pathogens in human cystic fibrosis macrophages.Positive Feedback Regulation between Transglutaminase 2 and Toll-Like Receptor 4 Signaling in Hepatic Stellate Cells Correlates with Liver Fibrosis Post Schistosoma japonicum Infection.Toward inclusive therapy with CFTR modulators: Progress and challenges.Correction of lung inflammation in a F508del CFTR murine cystic fibrosis model by the sphingosine-1-phosphate lyase inhibitor LX2931.Peripheral Protein Quality Control as a Novel Drug Target for CFTR Stabilizer
P2860
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P2860
Targeting autophagy as a novel strategy for facilitating the therapeutic action of potentiators on ΔF508 cystic fibrosis transmembrane conductance regulator.
description
2012 nî lūn-bûn
@nan
2012年の論文
@ja
2012年学术文章
@wuu
2012年学术文章
@zh-cn
2012年学术文章
@zh-hans
2012年学术文章
@zh-my
2012年学术文章
@zh-sg
2012年學術文章
@yue
2012年學術文章
@zh
2012年學術文章
@zh-hant
name
Targeting autophagy as a novel ...... embrane conductance regulator.
@ast
Targeting autophagy as a novel ...... embrane conductance regulator.
@en
type
label
Targeting autophagy as a novel ...... embrane conductance regulator.
@ast
Targeting autophagy as a novel ...... embrane conductance regulator.
@en
prefLabel
Targeting autophagy as a novel ...... embrane conductance regulator.
@ast
Targeting autophagy as a novel ...... embrane conductance regulator.
@en
P2093
P2860
P50
P921
P356
P1433
P1476
Targeting autophagy as a novel ...... embrane conductance regulator.
@en
P2093
Alessandro Luciani
Antonella De Matteis
Bob Scholte
Ilaria Russo
Luigi Maiuri
Manuela Gavina
Marco Silano
Massimo Pettoello-Mantovani
Rosa Carnuccio
Speranza Esposito
P2860
P304
P356
10.4161/AUTO.21483
P577
2012-08-09T00:00:00Z