Loss of expression of transforming growth factor beta in skin and skin tumors is associated with hyperproliferation and a high risk for malignant conversion.
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The latent transforming growth factor beta binding protein (LTBP) familyClinical challenges of chronic wounds: searching for an optimal animal model to recapitulate their complexityGenetic events and the role of TGF beta in epithelial tumour progression.Loss of expression of TGF-βs and their receptors in chronic skin lesions induced by sulfur mustard as compared with chronic contact dermatitis patientsMulti-scale Modelling for Threshold Dependent Differentiation.Expression and growth inhibitory effect of decapentaplegic Vg-related protein 6: evidence for a regulatory role in keratinocyte differentiation.Mammary tumor suppression by transforming growth factor beta 1 transgene expression.Human placental trophoblast as an in vitro model for tumor progression.Development of gene-switch transgenic mice that inducibly express transforming growth factor beta1 in the epidermis.Genetically null mice reveal a central role for epidermal growth factor receptor in the differentiation of the hair follicle and normal hair development.Transforming growth factor-beta 1 null mice. An animal model for inflammatory disordersDermal fibroblasts tumor suppression of ras-transformed keratinocytes is associated with induction of squamous cell differentiationThe role of TGF-beta in epithelial malignancy and its relevance to the pathogenesis of oral cancer (part II).Transforming growth factor beta1 (TGF-beta1) is a preoperative prognostic indicator in advanced gastric carcinomaEpidermal loss of Gαq confers a migratory and differentiation defect in keratinocytesTransforming growth factor beta 1 is an inducer of erythroid differentiation.A role for endogenous transforming growth factor beta 1 in Langerhans cell biology: the skin of transforming growth factor beta 1 null mice is devoid of epidermal Langerhans cells.The Role of TGFβ Signaling in Squamous Cell Cancer: Lessons from Mouse ModelsAbsence of alphavbeta6 integrin is linked to initiation and progression of periodontal diseaseDefects in transforming growth factor-beta signaling cooperate with a Ras oncogene to cause rapid aneuploidy and malignant transformation of mouse keratinocytes.Protection of islet grafts through transforming growth factor-β-induced tolerogenic dendritic cells.Transforming growth factor-beta signaling: emerging stem cell target in metastatic breast cancer?A role for TGFbeta1 in langerhans cell biology. Further characterization of the epidermal Langerhans cell defect in TGFbeta1 null mice.Radiation carcinogenesis in context: how do irradiated tissues become tumors?IL-12 deficiency suppresses 12-O-tetradecanoylphorbol-13-acetate-induced skin tumor development in 7,12-dimethylbenz(a)anthracene-initiated mouse skin through inhibition of inflammation.Tumors as organs: biologically augmenting radiation therapy by inhibiting transforming growth factor β activity in carcinomas.Epithelial integrins with special reference to oral epithelia.Long-Lived Epidermal Cancer-Initiating Cells.CD109 release from the cell surface in human keratinocytes regulates TGF-β receptor expression, TGF-β signalling and STAT3 activation: relevance to psoriasis.Dysregulation of autocrine TGF-beta isoform production and ligand responses in human tumour-derived and Ha-ras-transfected keratinocytes and fibroblasts.TGF-beta(1) and Smad4 overexpression induce a less invasive phenotype in highly invasive spindle carcinoma cells.Cell density-dependent proliferative effects of transforming growth factor (TGF)-beta 1, beta 2, and beta 3 in human chondrosarcoma cells HCS-2/8 are associated with changes in the expression of TGF-beta receptor type I.Increased sensitivity of transforming growth factor (TGF) beta 1 null cells to alkylating agents reveals a novel link between TGFbeta signaling and O(6)-methylguanine methyltransferase promoter hypermethylation.Defects in TGF-beta signaling overcome senescence of mouse keratinocytes expressing v-Ha-ras.TGF-beta isoforms are differentially expressed in increasing malignant grades of HaCaT keratinocytes, suggesting separate roles in skin carcinogenesis.Development of Novel Mouse Model of Ulcers Induced by Implantation of Magnets.Inhibition of TGF-β signaling supports high proliferative potential of diverse p63+ mouse epithelial progenitor cells in vitro.Opposite effect of stable transfection of bioactive transforming growth factor-beta 1 (TGF beta 1) versus exogenous TGF beta 1 treatment on expression of 92-kDa type IV collagenase in mouse skin squamous cell carcinoma CH72 cells.Uncoordinated regulation of mRNA expression of the three isoforms of transforming growth factor-beta in the mouse skin carcinogenesis model.Targeted expression of the E6 and E7 oncogenes of human papillomavirus type 16 in the epidermis of transgenic mice elicits generalized epidermal hyperplasia involving autocrine factors.
P2860
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P2860
Loss of expression of transforming growth factor beta in skin and skin tumors is associated with hyperproliferation and a high risk for malignant conversion.
description
1993 nî lūn-bûn
@nan
1993年の論文
@ja
1993年学术文章
@wuu
1993年学术文章
@zh-cn
1993年学术文章
@zh-hans
1993年学术文章
@zh-my
1993年学术文章
@zh-sg
1993年學術文章
@yue
1993年學術文章
@zh
1993年學術文章
@zh-hant
name
Loss of expression of transfor ...... risk for malignant conversion.
@ast
Loss of expression of transfor ...... risk for malignant conversion.
@en
type
label
Loss of expression of transfor ...... risk for malignant conversion.
@ast
Loss of expression of transfor ...... risk for malignant conversion.
@en
prefLabel
Loss of expression of transfor ...... risk for malignant conversion.
@ast
Loss of expression of transfor ...... risk for malignant conversion.
@en
P2093
P2860
P356
P1476
Loss of expression of transfor ...... risk for malignant conversion.
@en
P2093
Flanders KC
Hennings H
Karlsson S
Kulkarni AB
O'Reilly M
Tennenbaum T
P2860
P304
P356
10.1073/PNAS.90.13.6076
P407
P577
1993-07-01T00:00:00Z