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Stressing out the ER: a role of the unfolded protein response in prion-related disorders

Stressing out the ER: a role of the unfolded protein response in prion-related disorders

http://www.wikidata.org/entity/Q36393488

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Essential role of the unfolded protein response regulator GRP78/BiP in protection from neuronal apoptosis Calcineurin inhibition at the clinical phase of prion disease reduces neurodegeneration, improves behavioral alterations and increases animal survival ER chaperones in mammalian development and human diseases In vivo generation of neurotoxic prion protein: role for hsp70 in accumulation of misfolded isoforms A central role for calcineurin in protein misfolding neurodegenerative diseases.From structure to redox: The diverse functional roles of disulfides and implications in disease.Reduced translocation of nascent prion protein during ER stress contributes to neurodegeneration.Functional depletion of mahogunin by cytosolically exposed prion protein contributes to neurodegeneration Endoplasmic reticulum stress, PrP trafficking, and neurodegeneration.Perturbation of endoplasmic reticulum homeostasis facilitates prion replication.Prion protein misfolding affects calcium homeostasis and sensitizes cells to endoplasmic reticulum stress.Mutant prion protein expression is associated with an alteration of the Rab GDP dissociation inhibitor alpha (GDI)/Rab11 pathway Redox control of prion and disease pathogenesis.ER stress-induced clearance of misfolded GPI-anchored proteins via the secretory pathway.Metabolism of minor isoforms of prion proteins: Cytosolic prion protein and transmembrane prion protein Stress protein expression in early phase spinal cord ischemia/reperfusion injury Altered Prion protein expression pattern in CSF as a biomarker for Creutzfeldt-Jakob disease.The intricate mechanisms of neurodegeneration in prion diseases.Prion protein biosynthesis and its emerging role in neurodegeneration.Proteasomal dysfunction and endoplasmic reticulum stress enhance trafficking of prion protein aggregates through the secretory pathway and increase accumulation of pathologic prion protein PDIA3 Knockdown Exacerbates Free Fatty Acid-Induced Hepatocyte Steatosis and Apoptosis.The impact of the unfolded protein response on human disease Phenylbutyric acid suppresses protein accumulation-mediated ER stress in retrovirus-infected astrocytes and delays onset of paralysis in infected mice Overexpression of the Hspa13 (Stch) gene reduces prion disease incubation time in mice.Unfolded protein response transcription factor XBP-1 does not influence prion replication or pathogenesis.ER stress-mediated autophagy promotes Myc-dependent transformation and tumor growth.Interplay of endoplasmic reticulum stress and autophagy in neurodegenerative disorders.RAGE signaling contributes to neuroinflammation in infantile neuronal ceroid lipofuscinosis Opposing roles of prion protein in oxidative stress- and ER stress-induced apoptotic signaling.Emerging roles of extracellular vesicles in neurodegenerative disorders: focus on HIV-associated neurological complications.The Endoplasmic Reticulum Chaperone GRP78/BiP Modulates Prion Propagation in vitro and in vivo.Coordination of autophagy and the proteasome in resolving endoplasmic reticulum stress.Role of calcineurin in neurodegeneration produced by misfolded proteins and endoplasmic reticulum stress.Therapeutic strategies against protein misfolding in neurodegenerative diseases.The essential biology of the endoplasmic reticulum stress response for structural and computational biologists.The chaperone Grp78 in protein folding disorders of the nervous system.A molecular web: endoplasmic reticulum stress, inflammation, and oxidative stress.Prion degradation pathways: Potential for therapeutic intervention.Abnormal calcium homeostasis and protein folding stress at the ER: A common factor in familial and infectious prion disorders.The Protein-disulfide Isomerase ERp57 Regulates the Steady-state Levels of the Prion Protein.

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Stressing out the ER: a role of the unfolded protein response in prion-related disorders

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Stressing out the ER: a role of the unfolded protein response in prion-related disorders

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Caspase-12 mediates endoplasmic-reticulum-specific apoptosis and cytotoxicity by amyloid-beta

Coupling of stress in the ER to activation of JNK protein kinases by transmembrane protein kinase IRE1

ASK1 is essential for endoplasmic reticulum stress-induced neuronal cell death triggered by expanded polyglutamine repeats

Involvement of caspase-4 in endoplasmic reticulum stress-induced apoptosis and Abeta-induced cell death

Conversion of alpha-helices into beta-sheets features in the formation of the scrapie prion proteins

Prion diseases of humans and animals: their causes and molecular basis

Mice devoid of PrP are resistant to scrapie

Protein accumulation and neurodegeneration in the woozy mutant mouse is caused by disruption of SIL1, a cochaperone of BiP

Proteasomes and ubiquitin are involved in the turnover of the wild-type prion protein

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