Removing endogenous tau does not prevent tau propagation yet reduces its neurotoxicity - Wikidata - wikimedia - TriplyDB

Removing endogenous tau does not prevent tau propagation yet reduces its neurotoxicity

Removing endogenous tau does not prevent tau propagation yet reduces its neurotoxicity

http://www.wikidata.org/entity/Q36394952

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Tau physiology and pathomechanisms in frontotemporal lobar degeneration Ocular indicators of Alzheimer's: exploring disease in the retina A local insult of okadaic acid in wild-type mice induces tau phosphorylation and protein aggregation in anatomically distinct brain regions Human tau increases amyloid β plaque size but not amyloid β-mediated synapse loss in a novel mouse model of Alzheimer's disease.Pimozide reduces toxic forms of tau in TauC3 mice via 5' adenosine monophosphate-activated protein kinase-mediated autophagy.Extracellular Tau Paired Helical Filaments Differentially Affect Tau Pathogenic Mechanisms in Mitotic and Post-Mitotic Cells: Implications for Mechanisms of Tau Propagation in the Brain.DnaJ/Hsc70 chaperone complexes control the extracellular release of neurodegenerative-associated proteins.Prion-like propagation as a pathogenic principle in frontotemporal dementia.Tau reduction prevents neuronal loss and reverses pathological tau deposition and seeding in mice with tauopathy.The Prion-Like Behavior of Assembled Tau in Transgenic Mice.Neurodegenerative Disease Transmission and Transgenesis in Mice.Formation, release, and internalization of stable tau oligomers in cells.Targeting Neural Hyperactivity as a Treatment to Stem Progression of Late-Onset Alzheimer's Disease.The spread of prion-like proteins by lysosomes and tunneling nanotubes: Implications for neurodegenerative diseases.The CNS in inbred transgenic models of 4-repeat Tauopathy develops consistent tau seeding capacity yet focal and diverse patterns of protein deposition.No full admission for tau to the exclusive prion club yet.What is the evidence that tau pathology spreads through prion-like propagation?Evidence for sortilin modulating regional accumulation of human tau prions in transgenic mice.Tau-based therapies in neurodegeneration: opportunities and challenges.Amyloidogenesis of Tau protein.The use of mouse models to study cell-to-cell transmission of pathological tau.The role of microglia in processing and spreading of bioactive tau seeds in Alzheimer's disease

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Removing endogenous tau does not prevent tau propagation yet reduces its neurotoxicity

http://www.wikidata.org/entity/Q36394952

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2015 nî lūn-bûn

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2015年の論文

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2015年学术文章

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2015年学术文章

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2015年学术文章

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2015年学术文章

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2015年学术文章

@zh-sg

2015年學術文章

@yue

2015年學術文章

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2015年學術文章

@zh-hant

name

Removing endogenous tau does not prevent tau propagation yet reduces its neurotoxicity

@ast

Removing endogenous tau does not prevent tau propagation yet reduces its neurotoxicity

@en

type

label

Removing endogenous tau does not prevent tau propagation yet reduces its neurotoxicity

@ast

Removing endogenous tau does not prevent tau propagation yet reduces its neurotoxicity

@en

prefLabel

Removing endogenous tau does not prevent tau propagation yet reduces its neurotoxicity

@ast

Removing endogenous tau does not prevent tau propagation yet reduces its neurotoxicity

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The EMBO Journal

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Removing endogenous tau does not prevent tau propagation yet reduces its neurotoxicity

@en

P2093

Allyson Roe

http://www.w3.org/2001/XMLSchema#string

Amy M Pooler

http://www.w3.org/2001/XMLSchema#string

Eduardo A Maury

http://www.w3.org/2001/XMLSchema#string

George A Carlson

http://www.w3.org/2001/XMLSchema#string

Lubna Saqran

http://www.w3.org/2001/XMLSchema#string

Molly J Kirk

http://www.w3.org/2001/XMLSchema#string

Ozge Cagsal-Getkin

http://www.w3.org/2001/XMLSchema#string

Rose Pitstick

http://www.w3.org/2001/XMLSchema#string

Samantha Nicholls

http://www.w3.org/2001/XMLSchema#string

Sarah L DeVos

http://www.w3.org/2001/XMLSchema#string

P2860

Mechanisms of protein seeding in neurodegenerative diseases

Self-propagation of pathogenic protein aggregates in neurodegenerative diseases

Neuropathological alterations in Alzheimer disease

Neuropathological stageing of Alzheimer-related changes

Synapse loss and microglial activation precede tangles in a P301S tauopathy mouse model

Dendritic function of tau mediates amyloid-beta toxicity in Alzheimer's disease mouse models

CaMKII regulates the frequency-response function of hippocampal synapses for the production of both LTD and LTP

Trans-synaptic spread of tau pathology in vivo

A single protocol to detect transcripts of various types and expression levels in neural tissue and cultured cells: in situ hybridization using digoxigenin-labelled cRNA probes

Tau suppression in a neurodegenerative mouse model improves memory function

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3028-3041

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scholarly article

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10.15252/EMBJ.201592748

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24

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34

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Christopher M William

Tara L Spires-Jones

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2015-11-04T00:00:00Z

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26538322

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P932

4687785

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