Bone marrow microenvironmental changes underlie reduced RAG-mediated recombination and B cell generation in aged mice. - Wikidata - wikimedia - TriplyDB

Bone marrow microenvironmental changes underlie reduced RAG-mediated recombination and B cell generation in aged mice.

Bone marrow microenvironmental changes underlie reduced RAG-mediated recombination and B cell generation in aged mice.

http://www.wikidata.org/entity/Q36399584

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Immunosenescence: emerging challenges for an ageing population Age-Associated B Cells: A T-bet-Dependent Effector with Roles in Protective and Pathogenic Immunity Changes in primary lymphoid organs with aging Immunosenescence and organ transplantation Immunosenescence: deficits in adaptive immunity in the elderly Aging and immune function: molecular mechanisms to interventions Aging-associated inflammation promotes selection for adaptive oncogenic events in B cell progenitors Interleukin-7 and Immunosenescence.Apurinic/apyrimidinic endonuclease 2 is necessary for normal B cell development and recovery of lymphoid progenitors after chemotherapeutic challenge.T. brucei infection reduces B lymphopoiesis in bone marrow and truncates compensatory splenic lymphopoiesis through transitional B-cell apoptosis Transcriptional profiling of mRNAs and microRNAs in human bone marrow precursor B cells identifies subset- and age-specific variations.A B-cell subset uniquely responsive to innate stimuli accumulates in aged mice Aging impairs murine B cell differentiation and function in primary and secondary lymphoid tissues Inhibition of B Lymphopoiesis by Adipocytes and IL-1-Producing Myeloid-Derived Suppressor Cells Effects of aging on early B- and T-cell development.B cells, E2A, and aging.B cells and aging: gauging the interplay of generative, selective, and homeostatic events.Targets of immune regeneration in rheumatoid arthritis.B cells in the aging immune system: time to consider B-1 cells.Causes, consequences, and reversal of immune system aging.Bone marrow fat and the decline of B lymphopoiesis in rabbits Aging, B lymphopoiesis, and patterns of leukemogenesis.B cells and aging: balancing the homeostatic equation In senescence, age-associated B cells secrete TNFα and inhibit survival of B-cell precursors MEF2C protects bone marrow B-lymphoid progenitors during stress haematopoiesis.Theory and strategy for Pneumococcal vaccines in the elderly.Old mice retain bone marrow B1 progenitors, but lose B2 precursors, and exhibit altered immature B cell phenotype and light chain usage.NK cells in the CD19- B220+ bone marrow fraction are increased in senescence and reduce E2A and surrogate light chain proteins in B cell precursors.Deviation of the B cell pathway in senescent mice is associated with reduced surrogate light chain expression and altered immature B cell generation, phenotype, and light chain expression B cells and aging: molecules and mechanisms.Impaired B lymphopoiesis in old age: a role for inflammatory B cells?Impact of immunosenescence on transplant outcome.A comparative review of aging and B cell function in mice and humans IBD across the age spectrum: is it the same disease?Hematopoietic stem cell aging and chronic lymphocytic leukemia pathogenesis.Immune senescence: significance of the stromal microenvironment.The Intersection Of Aging Biology and The Pathobiology of Lung Diseases: A Joint NHLBI/NIA Workshop.Effects of age-related shifts in cellular function and local microenvironment upon the innate immune response to implants.Macrophages in age-related chronic inflammatory diseases.In old BALB/c mice, bone marrow pre-B cell and surrogate light chain reduction is associated with increased B cell reactivity to phosphorylcholine, but reduced T15 idiotype dominance.

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P2860

Bone marrow microenvironmental changes underlie reduced RAG-mediated recombination and B cell generation in aged mice.

http://www.wikidata.org/entity/Q36399584

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2004 nî lūn-bûn

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2004年学术文章

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2004年學術文章

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Bone marrow microenvironmental ...... cell generation in aged mice.

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Bone marrow microenvironmental ...... cell generation in aged mice.

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Bone marrow microenvironmental ...... cell generation in aged mice.

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Bone marrow microenvironmental ...... cell generation in aged mice.

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Bone marrow microenvironmental ...... cell generation in aged mice.

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Bone marrow microenvironmental ...... cell generation in aged mice.

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Alex P Sah

http://www.w3.org/2001/XMLSchema#string

David M Allman

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Joseph E Labrie

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Michael P Cancro

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Rachel M Gerstein

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P2860

Peripheral B cell maturation. I. Immature peripheral B cells in adults are heat-stable antigenhi and exhibit unique signaling characteristics

Peripheral B cell maturation. II. Heat-stable antigen(hi) splenic B cells are an immature developmental intermediate in the production of long-lived marrow-derived B cells

RAG-1 and RAG-2, adjacent genes that synergistically activate V(D)J recombination

Pairs of violet-light-excited fluorochromes for flow cytometric analysis.

Aging and the immune response to the Haemophilus influenzae type b capsular polysaccharide: retention of the dominant idiotype and antibody function in the elderly

Age-dependent changes in B lymphocyte development in man and mouse.

Deletion of the RAG2 C terminus leads to impaired lymphoid development in mice

The V(D)J recombination activating gene, RAG-1.

Bone marrow declines as a site of B-cell precursor differentiation with age: relationship to thymus involution

Resolution and characterization of pro-B and pre-pro-B cell stages in normal mouse bone marrow

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15314072

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