Deletion of the RAG2 C terminus leads to impaired lymphoid development in mice - Wikidata - wikimedia - TriplyDB

Deletion of the RAG2 C terminus leads to impaired lymphoid development in mice

Deletion of the RAG2 C terminus leads to impaired lymphoid development in mice

http://www.wikidata.org/entity/Q34329892

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The metallo-beta-lactamase/beta-CASP domain of Artemis constitutes the catalytic core for V(D)J recombination The plant homeodomain finger of RAG2 recognizes histone H3 methylated at both lysine-4 and arginine-2 RAG2 PHD finger couples histone H3 lysine 4 trimethylation with V(D)J recombination Recombination-activating gene proteins: more regulation, please A PHD finger motif in the C terminus of RAG2 modulates recombination activity Elucidating the domain architecture and functions of non-core RAG1: the capacity of a non-core zinc-binding domain to function in nuclear import and nucleic acid binding RAG2 mutants alter DSB repair pathway choice in vivo and illuminate the nature of 'alternative NHEJ'.Analysis of mutations from SCID and Omenn syndrome patients reveals the central role of the Rag2 PHD domain in regulating V(D)J recombination.An autoregulatory mechanism imposes allosteric control on the V(D)J recombinase by histone H3 methylation.Mobilization of RAG-generated signal ends by transposition and insertion in vivo Autoinhibition of DNA cleavage mediated by RAG1 and RAG2 is overcome by an epigenetic signal in V(D)J recombination Coupling of V(D)J recombination to the cell cycle suppresses genomic instability and lymphoid tumorigenesis.The C-terminal portion of RAG2 protects against transposition in vitro Overlapping signals for protein degradation and nuclear localization define a role for intrinsic RAG-2 nuclear uptake in dividing cells.Leaky RAG Deficiency in Adult Patients with Impaired Antibody Production against Bacterial Polysaccharide Antigens The bounty of RAGs: recombination signal complexes and reaction outcomes.Artemis sheds new light on V(D)J recombination.How to keep V(D)J recombination under control.Monoallelic gene expression: a repertoire of recurrent themes.New concepts in the regulation of an ancient reaction: transposition by RAG1/RAG2.Activation of 12/23-RSS-dependent RAG cleavage by hSWI/SNF complex in the absence of transcription.A dual interaction between the DNA damage response protein MDC1 and the RAG1 subunit of the V(D)J recombinase Impaired V(D)J recombination and lymphocyte development in core RAG1-expressing mice.Bone marrow microenvironmental changes underlie reduced RAG-mediated recombination and B cell generation in aged mice.RAG2 and XLF/Cernunnos interplay reveals a novel role for the RAG complex in DNA repair Understanding how the V(D)J recombinase catalyzes transesterification: distinctions between DNA cleavage and transposition.Metabolic sensor AMPK directly phosphorylates RAG1 protein and regulates V(D)J recombination.RAG2's non-core domain contributes to the ordered regulation of V(D)J recombination.Localized epigenetic changes induced by DH recombination restricts recombinase to DJH junctions A plant homeodomain in RAG-2 that binds Hypermethylated lysine 4 of histone H3 is necessary for efficient antigen-receptor-gene rearrangement.RAG: a recombinase diversified.Temporal and spatial regulation of V(D)J recombination: interactions of extrinsic factors with the RAG complex.Noncore RAG1 regions promote Vβ rearrangements and αβ T cell development by overcoming inherent inefficiency of Vβ recombination signal sequences.Allelic exclusion of immunoglobulin genes: models and mechanisms.Full-length RAG-2, and not full-length RAG-1, specifically suppresses RAG-mediated transposition but not hybrid joint formation or disintegration.Congenital defects in V(D)J recombination.V(D)J Recombination: Mechanism, Errors, and Fidelity.Modeling of the RAG reaction mechanism.The ATM Kinase Restrains Joining of Both VDJ Signal and Coding Ends.Increased frequency of aberrant V(D)J recombination products in core RAG-expressing mice.

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Deletion of the RAG2 C terminus leads to impaired lymphoid development in mice

http://www.wikidata.org/entity/Q34329892

description

2003 nî lūn-bûn

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2003 թուականի Յունուարին հրատարակուած գիտական յօդուած

@hyw

2003 թվականի հունվարին հրատարակված գիտական հոդված

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2003年の論文

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2003年論文

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2003年論文

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2003年論文

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2003年論文

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2003年論文

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2003年论文

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name

Deletion of the RAG2 C terminus leads to impaired lymphoid development in mice

@ast

Deletion of the RAG2 C terminus leads to impaired lymphoid development in mice

@en

Deletion of the RAG2 C terminus leads to impaired lymphoid development in mice

@nl

type

label

Deletion of the RAG2 C terminus leads to impaired lymphoid development in mice

@ast

Deletion of the RAG2 C terminus leads to impaired lymphoid development in mice

@en

Deletion of the RAG2 C terminus leads to impaired lymphoid development in mice

@nl

prefLabel

Deletion of the RAG2 C terminus leads to impaired lymphoid development in mice

@ast

Deletion of the RAG2 C terminus leads to impaired lymphoid development in mice

@en

Deletion of the RAG2 C terminus leads to impaired lymphoid development in mice

@nl

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PNAS.0237043100

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Proceedings of the National Academy of Sciences of the United States of America

P1476

Deletion of the RAG2 C terminus leads to impaired lymphoid development in mice

@en

P2093

Craig H Bassing

http://www.w3.org/2001/XMLSchema#string

Darryll D Dudley

http://www.w3.org/2001/XMLSchema#string

Frank Gartner

http://www.w3.org/2001/XMLSchema#string

Frederick W Alt

http://www.w3.org/2001/XMLSchema#string

Marjorie A Oettinger

http://www.w3.org/2001/XMLSchema#string

Robert Monroe

http://www.w3.org/2001/XMLSchema#string

Sadiqur R Talukder

http://www.w3.org/2001/XMLSchema#string

Sheryl K Elkin

http://www.w3.org/2001/XMLSchema#string

Yoshiko Akamatsu

http://www.w3.org/2001/XMLSchema#string

Yousuke Takahama

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P2860

A family of chromatin remodeling factors related to Williams syndrome transcription factor

RAG-1-deficient mice have no mature B and T lymphocytes

RAG-2-deficient mice lack mature lymphocytes owing to inability to initiate V(D)J rearrangement

The PHD finger: implications for chromatin-mediated transcriptional regulation

Gleaning non-trivial structural, functional and evolutionary information about proteins by iterative database searches

Structure and regulation of the mouse ing1 gene. Three alternative transcripts encode two phd finger proteins that have opposite effects on p53 function.

Dual role of RAG2 in V(D)J recombination: catalysis and regulation of ordered Ig gene assembly.

Ordered assembly of the V(D)J synaptic complex ensures accurate recombination

Assembly of the RAG1/RAG2 synaptic complex

Factors and forces controlling V(D)J recombination.

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1209-1214

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10.1073/PNAS.0237043100

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3

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100

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2003-01-16T00:00:00Z

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10946967

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12531919

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298752

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