Protein arginine deiminase 4: evidence for a reverse protonation mechanism.
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Externalized decondensed neutrophil chromatin occludes pancreatic ducts and drives pancreatitisCharacterization and inactivation of an agmatine deiminase from Helicobacter pyloriThe development of N-α-(2-carboxyl)benzoyl-N(5)-(2-fluoro-1-iminoethyl)-l-ornithine amide (o-F-amidine) and N-α-(2-carboxyl)benzoyl-N(5)-(2-chloro-1-iminoethyl)-l-ornithine amide (o-Cl-amidine) as second generation protein arginine deiminase (PAD) iSynthesis and Screening of a Haloacetamidine Containing Library To Identify PAD4 Selective InhibitorsBorn-Oppenheimer ab initio QM/MM molecular dynamics simulations of the hydrolysis reaction catalyzed by protein arginine deiminase 4.Probing the Roles of Calcium-Binding Sites during the Folding of Human Peptidylarginine Deiminase 4.Substrate specificity and kinetic studies of PADs 1, 3, and 4 identify potent and selective inhibitors of protein arginine deiminase 3.Mechanistic similarity and diversity among the guanidine-modifying members of the pentein superfamily.A fluopol-ABPP HTS assay to identify PAD inhibitors.Discovery of a new class of inhibitors for the protein arginine deiminase type 4 (PAD4) by structure-based virtual screening.Functional roles of the non-catalytic calcium-binding sites in the N-terminal domain of human peptidylarginine deiminase 4Ab initio QM/MM free-energy studies of arginine deiminase catalysis: the protonation state of the Cys nucleophileN-α-benzoyl-N5-(2-chloro-1-iminoethyl)-L-ornithine amide, a protein arginine deiminase inhibitor, reduces the severity of murine collagen-induced arthritis.Autodeimination of protein arginine deiminase 4 alters protein-protein interactions but not activity.Inhibiting protein arginine deiminases has antioxidant consequences.Identification of multiple structurally distinct, nonpeptidic small molecule inhibitors of protein arginine deiminase 3 using a substrate-based fragment methodChemical biology of protein arginine modifications in epigenetic regulationActivation of PAD4 in NET formation.Mechanistic studies of the agmatine deiminase from Listeria monocytogenesChemical mechanisms of histone lysine and arginine modificationsProtein arginine deiminase 4 (PAD4): Current understanding and future therapeutic potentialActive site cysteine is protonated in the PAD4 Michaelis complex: evidence from Born-Oppenheimer ab initio QM/MM molecular dynamics simulations.The protein arginine deiminases: Structure, function, inhibition, and disease.Citrullination of autoantigens implicates NETosis in the induction of autoimmunity.Insights into the mechanism of streptonigrin-induced protein arginine deiminase inactivationMechanistic studies of protein arginine deiminase 2: evidence for a substrate-assisted mechanismMechanistic studies on transcriptional coactivator protein arginine methyltransferase 1.Mechanistic studies of agmatine deiminase from multiple bacterial speciesPAD4: pathophysiology, current therapeutics and future perspective in rheumatoid arthritis.Role of citrullination modification catalyzed by peptidylarginine deiminase 4 in gene transcriptional regulation.A conserved tyrosyl-glutamyl catalytic dyad in evolutionarily linked enzymes: carbapenam synthetase and beta-lactam synthetase.Interrogation of the Active Sites of Protein Arginine Deiminases (PAD1, -2, and -4) Using Designer ProbesCysteine 351 is an essential nucleophile in catalysis by Porphyromonas gingivalis peptidylarginine deiminase.Haloacetamidine-based inactivators of protein arginine deiminase 4 (PAD4): evidence that general acid catalysis promotes efficient inactivation.Development and use of clickable activity based protein profiling agents for protein arginine deiminase 4.Profiling Protein Arginine Deiminase 4 (PAD4): a novel screen to identify PAD4 inhibitors.Inhibition of human dimethylarginine dimethylaminohydrolase-1 by S-nitroso-L-homocysteine and hydrogen peroxide. Analysis, quantification, and implications for hyperhomocysteinemia.Human Deiminases: Isoforms, Substrate Specificities, Kinetics, and Detection.Perspective on Protein Arginine Deiminase Activity-Bicarbonate Is a pH-Independent Regulator of Citrullination.Regulating NETosis: Increasing pH Promotes NADPH Oxidase-Dependent NETosis.
P2860
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P2860
Protein arginine deiminase 4: evidence for a reverse protonation mechanism.
description
2007 nî lūn-bûn
@nan
2007年の論文
@ja
2007年学术文章
@wuu
2007年学术文章
@zh-cn
2007年学术文章
@zh-hans
2007年学术文章
@zh-my
2007年学术文章
@zh-sg
2007年學術文章
@yue
2007年學術文章
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2007年學術文章
@zh-hant
name
Protein arginine deiminase 4: evidence for a reverse protonation mechanism.
@ast
Protein arginine deiminase 4: evidence for a reverse protonation mechanism.
@en
type
label
Protein arginine deiminase 4: evidence for a reverse protonation mechanism.
@ast
Protein arginine deiminase 4: evidence for a reverse protonation mechanism.
@en
prefLabel
Protein arginine deiminase 4: evidence for a reverse protonation mechanism.
@ast
Protein arginine deiminase 4: evidence for a reverse protonation mechanism.
@en
P2860
P356
P1433
P1476
Protein arginine deiminase 4: evidence for a reverse protonation mechanism.
@en
P2093
Monica Bhatia
Paul R Thompson
P2860
P304
P356
10.1021/BI700095S
P407
P577
2007-05-12T00:00:00Z