about
The development of N-α-(2-carboxyl)benzoyl-N(5)-(2-fluoro-1-iminoethyl)-l-ornithine amide (o-F-amidine) and N-α-(2-carboxyl)benzoyl-N(5)-(2-chloro-1-iminoethyl)-l-ornithine amide (o-Cl-amidine) as second generation protein arginine deiminase (PAD) iSubstrate specificity and kinetic studies of PADs 1, 3, and 4 identify potent and selective inhibitors of protein arginine deiminase 3.N-α-benzoyl-N5-(2-chloro-1-iminoethyl)-L-ornithine amide, a protein arginine deiminase inhibitor, reduces the severity of murine collagen-induced arthritis.Inhibitors and inactivators of protein arginine deiminase 4: functional and structural characterization.Development of a Plate-Based Screening Assay to Investigate the Substrate Specificity of the PRMT Family of Enzymes.Protein arginine deiminase 4: evidence for a reverse protonation mechanism.Felty's syndrome autoantibodies bind to deiminated histones and neutrophil extracellular chromatin trapsMechanistic studies of the agmatine deiminase from Listeria monocytogenesMechanistic studies of protein arginine deiminase 2: evidence for a substrate-assisted mechanismProbing adenylation: using a fluorescently labelled ATP probe to directly label and immunoprecipitate VopS substrates.Activity-based protein profiling reagents for protein arginine deiminase 4 (PAD4): synthesis and in vitro evaluation of a fluorescently labeled probeA fluoroacetamidine-based inactivator of protein arginine deiminase 4: design, synthesis, and in vitro and in vivo evaluation.Profiling Protein Arginine Deiminase 4 (PAD4): a novel screen to identify PAD4 inhibitors.Development of a clickable activity-based protein profiling (ABPP) probe for agmatine deiminases.Ibotenic acid lesions to ventrolateral thalamic nuclei disrupts trace and delay eyeblink conditioning in rabbits.Prefrontal control of trace versus delay eyeblink conditioning: role of the unconditioned stimulus in rabbits (Oryctolagus cuniculus).Prefrontal control of trace eyeblink conditioning in rabbits (Oryctolagus cuniculus) II: effects of type of unconditioned stimulus (airpuff vs. periorbital shock) and unconditioned stimulus intensity.Two Distinct Cyclodipeptide Synthases from a Marine Actinomycete Catalyze Biosynthesis of the Same Diketopiperazine Natural Product.Design, synthesis, and in vitro evaluation of an activity-based protein profiling (ABPP) probe targeting agmatine deiminasesThe development and characterization of a chemical probe targeting PRMT1 over PRMT5
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description
hulumtues
@sq
onderzoeker
@nl
researcher
@en
հետազոտող
@hy
name
Bryan Knuckley
@ast
Bryan Knuckley
@en
Bryan Knuckley
@es
Bryan Knuckley
@nl
Bryan Knuckley
@sl
type
label
Bryan Knuckley
@ast
Bryan Knuckley
@en
Bryan Knuckley
@es
Bryan Knuckley
@nl
Bryan Knuckley
@sl
prefLabel
Bryan Knuckley
@ast
Bryan Knuckley
@en
Bryan Knuckley
@es
Bryan Knuckley
@nl
Bryan Knuckley
@sl
P106
P21
P31
P496
0000-0002-6751-3762