Mutations in phosphoinositide metabolizing enzymes and human disease.
about
The PH domain proteins IPIP27A and B link OCRL1 to receptor recycling in the endocytic pathwayA PH domain within OCRL bridges clathrin-mediated membrane trafficking to phosphoinositide metabolismTwo closely related endocytic proteins that share a common OCRL-binding motif with APPL1Inositol lipids: from an archaeal origin to phosphatidylinositol 3,5-bisphosphate faults in human diseaseThe cellular and physiological functions of the Lowe syndrome protein OCRL1Podocyte endocytosis in the regulation of the glomerular filtration barrierPhosphoinositides in the mammalian endo-lysosomal networkOCRL1 engages with the F-BAR protein pacsin 2 to promote biogenesis of membrane-trafficking intermediates.A Synthetic Polyphosphoinositide Headgroup Surrogate in Complex with SHIP2 Provides a Rationale for Drug DiscoveryPIP kinases define PI4,5P₂signaling specificity by association with effectorsCrystal Structure of Human Myotubularin-Related Protein 1 Provides Insight into the Structural Basis of Substrate SpecificityPtdIns4P synthesis by PI4KIIIα at the plasma membrane and its impact on plasma membrane identityTranslation of the phosphoinositide code by PI effectorsCinderella story: PI4P goes from precursor to key signaling moleculeEmerging methodologies to investigate lipid-protein interactionsPhosphatidylinositol-4-phosphate 5-kinases and phosphatidylinositol 4,5-bisphosphate synthesis in the brainThe inositol Inpp5k 5-phosphatase affects osmoregulation through the vasopressin-aquaporin 2 pathway in the collecting systemMutations in INPP5K, Encoding a Phosphoinositide 5-Phosphatase, Cause Congenital Muscular Dystrophy with Cataracts and Mild Cognitive ImpairmentSHIP2 multiple functions: a balance between a negative control of PtdIns(3,4,5)P₃ level, a positive control of PtdIns(3,4)P₂ production, and intrinsic docking properties.Zebrafish MTMR14 is required for excitation-contraction coupling, developmental motor function and the regulation of autophagy.The CD3 zeta subunit contains a phosphoinositide-binding motif that is required for the stable accumulation of TCR-CD3 complex at the immunological synapse.Triggering actin comets versus membrane ruffles: distinctive effects of phosphoinositides on actin reorganizationOptogenetic control of phosphoinositide metabolism.Screening assay for small-molecule inhibitors of synaptojanin 1, a synaptic phosphoinositide phosphatase.Phosphoinositide turnover in Toll-like receptor signaling and trafficking.Phosphatidylinositol 4,5-bisphosphate: targeted production and signalingPhosphatidylinositol 3,5-bisphosphate (PI(3,5)P2) potentiates cardiac contractility via activation of the ryanodine receptorA homogeneous, high-throughput assay for phosphatidylinositol 5-phosphate 4-kinase with a novel, rapid substrate preparation.Genetic variants in the inositol phosphate metabolism pathway and risk of different types of cancer.Phosphoinositides in cell architecture.Phosphoinositides regulate ion channels.Voltage-sensing phosphatase modulation by a C2 domainDetection and manipulation of phosphoinositides.A dPIP5K dependent pool of phosphatidylinositol 4,5 bisphosphate (PIP2) is required for G-protein coupled signal transduction in Drosophila photoreceptorsc-Fos activates and physically interacts with specific enzymes of the pathway of synthesis of polyphosphoinositidesCellular and molecular interactions of phosphoinositides and peripheral proteinsA novel mass assay to quantify the bioactive lipid PtdIns3P in various biological samplesRequirement of Phosphoinositides Containing Stearic Acid To Control Cell PolarityThe CMT4B disease-causing phosphatases Mtmr2 and Mtmr13 localize to the Schwann cell cytoplasm and endomembrane compartments, where they depend upon each other to achieve wild-type levels of protein expression.An Emerging Role for PI5P in T Cell Biology.
P2860
Q24336978-83573C67-A7F4-46A0-A86A-9A697EA61ACFQ24338714-15620DCF-5465-4624-8534-D5FF078AF227Q24624573-F1CC253A-014C-478F-9BB3-6849CF37CF5FQ26852772-4099DC78-7636-4779-8252-3E8443D7252DQ26862286-6EF32E0A-02BD-4C83-836C-28A406824E5FQ27004073-E9B5C4D1-AE67-4A0A-A141-D458DF73844CQ27025523-63FAE0A1-8E68-437A-BC06-7F3C824E9FB7Q27305561-3998A4F5-EAEB-4880-81AC-D1BA3578748EQ27677243-1D2FDAB9-2FF4-4D02-8079-7DEC7A0C7FAFQ28083975-633316EA-1A29-443E-A44E-99A4989847ACQ28117248-DA572E7D-451E-40FA-B533-DF0CAE2AA330Q28118990-CC555320-B31D-4A4A-B05C-7E4ED0F5E8DAQ28285651-263CD030-008D-4556-99CF-5EC3E9D73D67Q28301748-1467D5F2-9E9A-4A48-809E-1DCCC8C3F352Q28386247-004CFAD1-7DE0-47AE-A921-641A3A50C39AQ28506799-12D5D817-1DE0-4B6E-9DC4-7BC512302F4AQ28508029-62E234FD-C21A-4F3F-87EE-4C3DC7802746Q30032671-83EC02CC-CA7E-47FB-8315-138FC83E8EEBQ30155578-1FB4EBB2-8678-4910-A589-623A7F4FB662Q30494835-A738D46C-0935-4CE6-9E7D-2BC8D71D8F6EQ30500933-0E2FC49A-FB54-4B97-A53D-7AF615F49624Q30515754-34268EED-B9A9-4F46-968B-42AFB96A60B4Q30524739-23CE3215-6B40-4AB2-ACE0-1D8438BFE25DQ33561690-F2A39CBE-D584-4F4F-9757-D70C30BF17CAQ34179854-2B33DF4E-6A2A-42AF-B6B8-EF7D172AD15EQ34338443-EAD8591D-5C0B-49FA-BED4-4130E2A1A867Q34401162-3AF71A93-D087-47BA-AD12-F637C9E9C592Q34552164-88B0A330-F0F1-4610-9519-C864BB8CFABBQ35086684-DAAABA14-2098-49BC-8A40-84F69E24918FQ35119240-F245CAF6-5FA7-471A-BC7E-EA18274E8CBEQ35192402-A676AC47-4E0A-494A-AF57-4BCE7F29D6BCQ35313400-9A4332B0-ABC0-42D5-AD28-550268DE568EQ35525004-69E3D4B1-6D92-4F09-B415-29E8CE7DEAA9Q35551486-D5776281-E35F-41E5-856E-F19ACA17B859Q35612230-EF1D9845-CE85-4DC0-95B4-52AC02D599B3Q35794843-DCB47E2F-AE17-4FE1-A043-88F395B37D41Q36231711-B5D75A47-B0BF-49BF-9CA9-A29A5EAA9D3FQ36597237-8DDFE0DA-0065-49A2-93EF-C3534B89A544Q36709124-A4EC2104-15F9-4AA8-90B1-68D7329ABB32Q36732873-D670DE5E-50CF-483E-993D-D0AEEAFB7BF8
P2860
Mutations in phosphoinositide metabolizing enzymes and human disease.
description
2009 nî lūn-bûn
@nan
2009年の論文
@ja
2009年学术文章
@wuu
2009年学术文章
@zh-cn
2009年学术文章
@zh-hans
2009年学术文章
@zh-my
2009年学术文章
@zh-sg
2009年學術文章
@yue
2009年學術文章
@zh
2009年學術文章
@zh-hant
name
Mutations in phosphoinositide metabolizing enzymes and human disease.
@ast
Mutations in phosphoinositide metabolizing enzymes and human disease.
@en
type
label
Mutations in phosphoinositide metabolizing enzymes and human disease.
@ast
Mutations in phosphoinositide metabolizing enzymes and human disease.
@en
prefLabel
Mutations in phosphoinositide metabolizing enzymes and human disease.
@ast
Mutations in phosphoinositide metabolizing enzymes and human disease.
@en
P2860
P1433
P1476
Mutations in phosphoinositide metabolizing enzymes and human disease.
@en
P2093
Heather J McCrea
P2860
P356
10.1152/PHYSIOL.00035.2008
P577
2009-02-01T00:00:00Z