Ro/SSA autoantibodies directly bind cardiomyocytes, disturb calcium homeostasis, and mediate congenital heart block. - Wikidata - wikimedia - TriplyDB

Ro/SSA autoantibodies directly bind cardiomyocytes, disturb calcium homeostasis, and mediate congenital heart block.

Ro/SSA autoantibodies directly bind cardiomyocytes, disturb calcium homeostasis, and mediate congenital heart block.

http://www.wikidata.org/entity/Q36402505

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Structural basis for PRYSPRY-mediated tripartite motif (TRIM) protein function TRIM21 is an IgG receptor that is structurally, thermodynamically, and kinetically conserved 52-kDa Ro/SSA epitopes preferentially recognized by antibodies from mothers of children with neonatal lupus and congenital heart block Structural organization and Zn2+-dependent subdomain interactions involving autoantigenic epitopes in the Ring-B-box-coiled-coil (RBCC) region of Ro52 Origin and diversification of TRIM ubiquitin ligases.Mass spectrometric and peptide chip characterization of an assembled epitope: analysis of a polyclonal antibody model serum directed against the Sjøgren/systemic lupus erythematosus autoantigen TRIM21.Congenital heart block: identification of autoantibody binding site on the extracellular loop (domain I, S5-S6) of alpha(1D) L-type Ca channel.Role of calcium channels in congenital heart block Impaired clearance of apoptotic cardiocytes is linked to anti-SSA/Ro and -SSB/La antibodies in the pathogenesis of congenital heart block.Congenital heart block maternal sera autoantibodies target an extracellular epitope on the α1G T-type calcium channel in human fetal hearts.Rescue and worsening of congenital heart block-associated electrocardiographic abnormalities in two transgenic mice.Neonatal Lupus erythematosus Following Rheumatoid Arthritis: Case Report and Literature Review.Lupus and pregnancy: complex yet manageable.Maternal and neonatal outcomes in pregnant women with autoimmune diseases in Pavia, Italy.Autoantigen TRIM21/Ro52 as a Possible Target for Treatment of Systemic Lupus Erythematosus Umbilical cord blood levels of maternal antibodies reactive with p200 and full-length Ro 52 in the assessment of risk for cardiac manifestations of neonatal lupus.Congenital heart block: evidence for a pathogenic role of maternal autoantibodies Autoantibodies to intracellular autoantigens and their B-cell epitopes: molecular probes to study the autoimmune response.Pregnancy outcomes in patients with autoimmune diseases and anti-Ro/SSA antibodies.Mechanisms of Disease: primary Sjögren's syndrome and the type I interferon system.Autoantibodies from mice exposed to Libby amphibole asbestos bind SSA/Ro52-enriched apoptotic blebs of murine macrophages Maternal autoantibody profiles at risk for autoimmune congenital heart block: a prospective study in high-risk patients.The tight junction protein CAR regulates cardiac conduction and cell-cell communication.Sjögren's syndrome--a plethora of clinical and immunological phenotypes with a complex genetic background.Dying right to live longer: positing apoptosis as a link between maternal autoantibodies and congenital heart block.Pathogenicity and proteomic signatures of autoantibodies to Ro and La.Management of pregnancy in systemic lupus erythematosus.Cardiac Fibroblast Transcriptome Analyses Support a Role for Interferogenic, Profibrotic and Inflammatory Genes in Anti-SSA/Ro-Associated Congenital Heart Block.Congenital heart block and immune mediated sensorineural hearing loss: possible cross reactivity of immune response.A review of the role and clinical utility of anti-Ro52/TRIM21 in systemic autoimmunity.Autoimmune channelopathies as a novel mechanism in cardiac arrhythmias.Ro52, Ro60 and La IgG autoantibody levels and Ro52 IgG subclass profiles longitudinally throughout pregnancy in congenital heart block risk pregnancies.A population-based investigation of the autoantibody profile in mothers of children with atrioventricular block.Passive transfer of antibodies to the linear epitope 60 kD Ro 273-289 induces features of Sjögren's syndrome in naive mice.Structurally derived mutations define congenital heart block-related epitopes within the 200-239 amino acid stretch of the Ro52 protein.Incident cases of primary Sjögren's syndrome during a 5-year period in Stockholm County: a descriptive study of the patients and their characteristics.Autoantibodies in Sjögren's Syndrome.Identification of discrete epitopes of Ro52p200 and association with fetal cardiac conduction system manifestations in a rodent model.Antibodies to amino acid 200-239 (p200) of Ro52 as serological markers for the risk of developing congenital heart block.Autoantibodies Associated With Connective Tissue Diseases: What Meaning for Clinicians?

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P2860

Ro/SSA autoantibodies directly bind cardiomyocytes, disturb calcium homeostasis, and mediate congenital heart block.

http://www.wikidata.org/entity/Q36402505

description

2005 nî lūn-bûn

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2005年学术文章

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2005年学术文章

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2005年學術文章

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2005年學術文章

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2005年學術文章

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name

Ro/SSA autoantibodies directly ...... ediate congenital heart block.

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Ro/SSA autoantibodies directly ...... ediate congenital heart block.

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type

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Ro/SSA autoantibodies directly ...... ediate congenital heart block.

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Ro/SSA autoantibodies directly ...... ediate congenital heart block.

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prefLabel

Ro/SSA autoantibodies directly ...... ediate congenital heart block.

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Ro/SSA autoantibodies directly ...... ediate congenital heart block.

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Journal of Experimental Medicine

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Ro/SSA autoantibodies directly ...... ediate congenital heart block.

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P2093

Lars Ottosson

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Maria Sunnerhagen

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Peter Thorén

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Saad Muhallab

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Stina Salomonsson

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Sven-Erik Sonesson

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Tomas Olsson

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Vijay K Kuchroo

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P2860

Regulation of cell death: the calcium-apoptosis link

Cloning and characterization of two human Ro52-specific monoclonal autoantibodies directed towards a domain associated with congenital heart block.

Induction of neonatal lupus in pups of mice immunized with synthetic peptides derived from amino acid sequences of the serotoninergic 5-HT4 receptor.

Analysis of B-cell epitopes of the Ro/SS-A autoantigen.

Comparison of treatment with fluorinated glucocorticoids to the natural history of autoantibody-associated congenital heart block: retrospective review of the research registry for neonatal lupus.

Outcome of isolated congenital complete heart block diagnosed in utero.

Signs of first-degree heart block occur in one-third of fetuses of pregnant women with anti-SSA/Ro 52-kd antibodies.

Immunohistologic evidence supports apoptosis, IgG deposition, and novel macrophage/fibroblast crosstalk in the pathologic cascade leading to congenital heart block.

Significantly increased maternal and fetal IgG autoantibody levels to 52 kD Ro (SS-A) and La(SS-B) in complete congenital heart block.

P304

11-17

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10.1084/JEM.20041859

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1

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201

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Marie Wahren-Herlenius

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2005-01-01T00:00:00Z

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8101133

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15630133

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2212767

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