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Defective B cell tolerance checkpoints in systemic lupus erythematosus

Defective B cell tolerance checkpoints in systemic lupus erythematosus

http://www.wikidata.org/entity/Q36402748

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Signalling of the BCR is regulated by a lipid rafts-localised transcription factor, Bright.IRAK-4- and MyD88-dependent pathways are essential for the removal of developing autoreactive B cells in humans Clinical value of multiplexed bead-based immunoassays for detection of autoantibodies to nuclear antigens Role of Natural Autoantibodies and Natural IgM Anti-Leucocyte Autoantibodies in Health and Disease Defects in Germinal Center Selection in SLE Immune-regulatory mechanisms in systemic autoimmune and rheumatic diseases Siglecs as sensors of self in innate and adaptive immune responses Resolve, revise, and relax: the 3 Rs of B cell repertoire adjustment B cells in chronic graft-versus-host disease Autoantibodies in systemic autoimmune diseases: specificity and pathogenicity Meta-analysis of shared genetic architecture across ten pediatric autoimmune diseases Autophagy is activated in systemic lupus erythematosus and required for plasmablast development Recurrent Potent Human Neutralizing Antibodies to Zika Virus in Brazil and Mexico.Endocytic sequestration of the B cell antigen receptor and toll-like receptor 9 in anergic cells.Redesigned HIV antibodies exhibit enhanced neutralizing potency and breadth.Quantification of specific T and B cells immunological markers in children with chronic and transient ITP.Phenotypic characterization of autoreactive B cells--checkpoints of B cell tolerance in patients with systemic lupus erythematosus Restoring the balance: immunotherapeutic combinations for autoimmune disease Aberrant Epstein-Barr viral infection in systemic lupus erythematosus Pathogenesis of human systemic lupus erythematosus: recent advances.The role of B cells in lupus pathogenesis.Antibody Reactivity of B Cells in Lupus Patients with Increased Disease Activity and ARID3a Expression.Antiviral immune responses: triggers of or triggered by autoimmunity?A cryptic polyreactive antibody recognizes distinct clades of HIV-1 glycoprotein 120 by an identical binding mechanism Rationale for B cell targeting in SLE The lupus susceptibility locus Sle1 breaches peripheral B cell tolerance at the antibody-forming cell and germinal center checkpoints Memory B cell antibodies to HIV-1 gp140 cloned from individuals infected with clade A and B viruses.Phenotypic and functional abnormalities of bone marrow-derived dendritic cells in systemic lupus erythematosus Decreased frequency and activated phenotype of blood CD27 IgD IgM B lymphocytes is a permanent abnormality in systemic lupus erythematosus patients.Germinal center exclusion of autoreactive B cells is defective in human systemic lupus erythematosus.Identification of autoantibody clusters that best predict lupus disease activity using glomerular proteome arrays.Increased levels of prolactin receptor expression correlate with the early onset of lupus symptoms and increased numbers of transitional-1 B cells after prolactin treatment Antibody repertoires in humanized NOD-scid-IL2Rγ(null) mice and human B cells reveals human-like diversification and tolerance checkpoints in the mouse Central B-cell tolerance: where selection begins.Practical considerations on the use of rituximab in autoimmune neurological disorders Subversion of B lymphocyte tolerance by hydralazine, a potential mechanism for drug-induced lupus.Dendritic cell subsets in health and disease.B cell receptor light chain repertoires show signs of selection with differences between groups of healthy individuals and SLE patients.Naive CD4 T cells constitutively express CD40L and augment autoreactive B cell survival.Accumulation of self-reactive naïve and memory B cell reveals sequential defects in B cell tolerance checkpoints in Sjögren's syndrome.

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P2860

Defective B cell tolerance checkpoints in systemic lupus erythematosus

http://www.wikidata.org/entity/Q36402748

description

2005 nî lūn-bûn

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2005年の論文

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2005年学术文章

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2005年学术文章

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2005年学术文章

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2005年学术文章

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2005年学术文章

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2005年學術文章

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2005年學術文章

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2005年學術文章

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name

Defective B cell tolerance checkpoints in systemic lupus erythematosus

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Defective B cell tolerance checkpoints in systemic lupus erythematosus

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Defective B cell tolerance checkpoints in systemic lupus erythematosus

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Defective B cell tolerance checkpoints in systemic lupus erythematosus

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prefLabel

Defective B cell tolerance checkpoints in systemic lupus erythematosus

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Defective B cell tolerance checkpoints in systemic lupus erythematosus

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P1433

Journal of Experimental Medicine

P1476

Defective B cell tolerance checkpoints in systemic lupus erythematosus

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P2093

Eric Meffre

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Hedda Wardemann

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Johanna Hammersen

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Makoto Tsuiji

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Sergey Yurasov

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Virginia Pascual

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P2860

TACI and BCMA are receptors for a TNF homologue implicated in B-cell autoimmune disease

I-PLA(2) activation during apoptosis promotes the exposure of membrane lysophosphatidylcholine leading to binding by natural immunoglobulin M antibodies and complement activation

Updating the American College of Rheumatology revised criteria for the classification of systemic lupus erythematosus

Chromatin-IgG complexes activate B cells by dual engagement of IgM and Toll-like receptors

IgG Fc receptors

Antinuclear antibodies: diagnostic markers for autoimmune diseases and probes for cell biology

Predominant autoantibody production by early human B cell precursors

Most peripheral B cells in mice are ligand selected.

B cell development in the spleen takes place in discrete steps and is determined by the quality of B cell receptor-derived signals.

Repertoire selection by pre-B-cell receptors and B-cell receptors, and genetic control of B-cell development from immature to mature B cells.

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703-711

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10.1084/JEM.20042251

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5

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201

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Michel C. Nussenzweig

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2005-02-28T00:00:00Z

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7995969

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15738055

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2212839

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