Coexistence of multivalent and monovalent TCRs explains high sensitivity and wide range of response. - Wikidata - wikimedia - TriplyDB

Coexistence of multivalent and monovalent TCRs explains high sensitivity and wide range of response.

Coexistence of multivalent and monovalent TCRs explains high sensitivity and wide range of response.

http://www.wikidata.org/entity/Q36402779

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B cell activation involves nanoscale receptor reorganizations and inside-out signaling by Syk An induced rebinding model of antigen discrimination Ultrasensitivity in the Cofilin Signaling Module: A Mechanism for Tuning T Cell Responses Narrowing the Gap: Preserving Repertoire Diversity Despite Clonal Selection during the CD4 T Cell Response Linking form to function: Biophysical aspects of artificial antigen presenting cell design Super-resolution characterization of TCR-dependent signaling clusters T cell antigen recognition at the cell membrane Selective Ligand Recognition by a Diversity-Generating Retroelement Variable Protein Structure of the Chicken CD3 / Heterodimer and Its Assembly with the T Cell Receptor T cell receptor-proximal signals are sustained in peripheral microclusters and terminated in the central supramolecular activation cluster.Cytoskeletal control of CD36 diffusion promotes its receptor and signaling function.The SCHOOL of nature: I. Transmembrane signaling.Stoichiometry and intracellular fate of TRIM-containing TCR complexes.T cell receptor signal initiation induced by low-grade stimulation requires the cooperation of LAT in human T cells.In vitro membrane reconstitution of the T-cell receptor proximal signaling network.TCR Microclusters pre-exist and contain molecules necessary for TCR signal transduction.Quantitative analysis of protein phosphorylations and interactions by multi-colour IP-FCM as an input for kinetic modelling of signalling networks The kinetics of two-dimensional TCR and pMHC interactions determine T-cell responsiveness.Organization of the resting TCR in nanoscale oligomers.How the immune system talks to itself: the varied role of synapses Evidence that the density of self peptide-MHC ligands regulates T-cell receptor signaling.P-selectin glycoprotein ligand-1 forms dimeric interactions with E-selectin but monomeric interactions with L-selectin on cell surfaces.The SCHOOL of nature: III. From mechanistic understanding to novel therapies Nanoclustering as a dominant feature of plasma membrane organization.Molecular architecture of the αβ T cell receptor-CD3 complex.Rapid perturbation in viremia levels drives increases in functional avidity of HIV-specific CD8 T cells.Nanoscale ligand spacing influences receptor triggering in T cells and NK cells Physical and functional bivalency observed among TCR/CD3 complexes isolated from primary T cells.Escape from highly effective public CD8+ T-cell clonotypes by HIV The T cell receptor triggering apparatus is composed of monovalent or monomeric proteins.The nanoscale organization of the B lymphocyte membrane.Functional nanoscale organization of signaling molecules downstream of the T cell antigen receptor.Interaction of streptavidin-based peptide-MHC oligomers (tetramers) with cell-surface TCRs TCR and Lat are expressed on separate protein islands on T cell membranes and concatenate during activation.TCR-peptide-MHC interactions in situ show accelerated kinetics and increased affinity.Quantum dot fluorescence characterizes the nanoscale organization of T cell receptors for antigen.Single-molecule level analysis of the subunit composition of the T cell receptor on live T cells Synthetic multivalent ligands as probes of signal transduction T-cell antigen-receptor stoichiometry: pre-clustering for sensitivity.Insights from in situ analysis of TCR-pMHC recognition: response of an interaction network.

P2860

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P2860

Coexistence of multivalent and monovalent TCRs explains high sensitivity and wide range of response.

http://www.wikidata.org/entity/Q36402779

description

2005 nî lūn-bûn

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2005年学术文章

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Coexistence of multivalent and ...... ty and wide range of response.

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Coexistence of multivalent and ...... ty and wide range of response.

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Coexistence of multivalent and ...... ty and wide range of response.

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Coexistence of multivalent and ...... ty and wide range of response.

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Hisse M van Santen

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Ignacio Arechaga

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Pilar Cabezas

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P2860

Recruitment of Nck by CD3 epsilon reveals a ligand-induced conformational change essential for T cell receptor signaling and synapse formation

The CD3-gamma and CD3-delta subunits of the T cell antigen receptor can be expressed within distinct functional TCR/CD3 complexes

Four A6-TCR/peptide/HLA-A2 structures that generate very different T cell signals are nearly identical

A T cell receptor CDR3beta loop undergoes conformational changes of unprecedented magnitude upon binding to a peptide/MHC class I complex

A structural basis for the selection of dominant alphabeta T cell receptors in antiviral immunity

Blue native electrophoresis for isolation of membrane protein complexes in enzymatically active form

Tetraspan microdomains distinct from lipid rafts enrich select peptide-MHC class II complexes.

Increased TCR avidity after T cell activation: a mechanism for sensing low-density antigen.

High sensitivity, low affinity--paradox of T-cell receptor recognition.

Engagement of T cell receptor triggers its recruitment to low-density detergent-insoluble membrane domains.

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493-503

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202

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Wolfgang Schamel

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Balbino Alarcón

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7671989

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16087711

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2212847

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