about
End-binding protein 1 controls signal propagation from the T cell receptor.Recruitment of Nck by CD3 epsilon reveals a ligand-induced conformational change essential for T cell receptor signaling and synapse formationInteraction between the N-terminal SH3 domain of Nck-alpha and CD3-epsilon-derived peptides: non-canonical and canonical recognition motifsT cell receptor engagement triggers its CD3epsilon and CD3zeta subunits to adopt a compact, locked conformationThe Rho exchange factors Vav2 and Vav3 favor skin tumor initiation and promotion by engaging extracellular signaling loopsAurora A drives early signalling and vesicle dynamics during T-cell activation.H-ras and N-ras are dispensable for T-cell development and activation but critical for protective Th1 immunityNck recruitment to the TCR required for ZAP70 activation during thymic development.Human TCR that incorporate CD3zeta induce highly preferred pairing between TCRalpha and beta chains following gene transfer.T cell receptor internalization from the immunological synapse is mediated by TC21 and RhoG GTPase-dependent phagocytosis.Organization of the resting TCR in nanoscale oligomers.A conformational change senses the strength of T cell receptor-ligand interaction during thymic selection.Initiation of TCR signaling: regulation within CD3 dimers.T cell receptor engagement by peptide-MHC ligands induces a conformational change in the CD3 complex of thymocytesThe Ras-like protein R-Ras2/TC21 is important for proper mammary gland development.Coexistence of multivalent and monovalent TCRs explains high sensitivity and wide range of response.An orderly inactivation of intracellular retention signals controls surface expression of the T cell antigen receptor.T-cell antigen-receptor stoichiometry: pre-clustering for sensitivity.Role of chimaerins, a group of Rac-specific GTPase activating proteins, in T-cell receptor signaling.Conformational model.Two receptors, two kinases, and T cell lineage determination.The immunological synapse: a cause or consequence of T-cell receptor triggering?TCR Nanoclusters as the Framework for Transmission of Conformational Changes and Cooperativity.Receptor Pre-Clustering and T cell Responses: Insights into Molecular Mechanisms.Crammed signaling motifs in the T-cell receptor.The CD3 conformational change in the γδ T cell receptor is not triggered by antigens but can be enforced to enhance tumor killing.Contribution of the R-Ras2 GTP-binding protein to primary breast tumorigenesis and late-stage metastatic disease.MTOC translocation modulates IS formation and controls sustained T cell signalingThe extracellular part of zeta is buried in the T cell antigen receptor complex.A native antibody-based mobility-shift technique (NAMOS-assay) to determine the stoichiometry of multiprotein complexes.Role of Fyn in the rearrangement of tubulin cytoskeleton induced through TCR.CD3ε recruits Numb to promote TCR degradation.Ligand-induced conformational change in the T-cell receptor associated with productive immune synapses.Engaged and bystander T cell receptors are down-modulated by different endocytotic pathways.Biochemical differences in the alphabeta T cell receptor.CD3 surface complex between CD8+ and CD4+ human mature T lymphocytes.TCR engagement induces proline-rich tyrosine kinase-2 (Pyk2) translocation to the T cell-APC interface independently of Pyk2 activity and in an immunoreceptor tyrosine-based activation motif-mediated fashion.RRas2, RhoG and T-cell phagocytosis.Activation outcomes induced in naïve CD8 T-cells by macrophages primed via "phagocytic" and nonphagocytic pathways.Different composition of the human and the mouse gammadelta T cell receptor explains different phenotypes of CD3gamma and CD3delta immunodeficiencies.Tubulin and actin interplay at the T cell and antigen-presenting cell interface.
P50
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P50
description
onderzoeker
@nl
name
Balbino Alarcón
@ast
Balbino Alarcón
@en
Balbino Alarcón
@es
Balbino Alarcón
@nl
Balbino Alarcón
@sl
type
label
Balbino Alarcón
@ast
Balbino Alarcón
@en
Balbino Alarcón
@es
Balbino Alarcón
@nl
Balbino Alarcón
@sl
prefLabel
Balbino Alarcón
@ast
Balbino Alarcón
@en
Balbino Alarcón
@es
Balbino Alarcón
@nl
Balbino Alarcón
@sl
P106
P21
P31
P569
2000-01-01T00:00:00Z