Class switching in B cells lacking 3' immunoglobulin heavy chain enhancers. - Wikidata - wikimedia - TriplyDB

Class switching in B cells lacking 3' immunoglobulin heavy chain enhancers.

Class switching in B cells lacking 3' immunoglobulin heavy chain enhancers.

http://www.wikidata.org/entity/Q36404262

about

Plasma cell differentiation requires the transcription factor XBP-1 AID targeting is dependent on RNA polymerase II pausing.The IgH 3' regulatory region and c-myc-induced B-cell lymphomagenesis The HoxC4 homeodomain protein mediates activation of the immunoglobulin heavy chain 3' hs1,2 enhancer in human B cells. Relevance to class switch DNA recombination Elucidation of the enigmatic IgD class-switch recombination via germline deletion of the IgH 3' regulatory region.AID-induced remodeling of immunoglobulin genes and B cell fate.Switch recombination and somatic hypermutation are controlled by the heavy chain 3' enhancer region.Functional anatomy of the immunoglobulin heavy chain 3΄ super-enhancer needs not only core enhancer elements but also their unique DNA context Chromatin architecture near a potential 3' end of the igh locus involves modular regulation of histone modifications during B-Cell development and in vivo occupancy at CTCF sites.The road to the production of IgE is long and winding.Elucidation of IgH intronic enhancer functions via germ-line deletion Regulation of immunoglobulin class-switch recombination: choreography of noncoding transcription, targeted DNA deamination, and long-range DNA repair.Regulated T-cell development: a victim of multiple conspiracies.Transgenes of the mouse immunoglobulin heavy chain locus, lacking distal elements in the 3' regulatory region, are impaired for class switch recombination Isotype class switching and the pathogenesis of multiple myeloma.The ARID family transcription factor bright is required for both hematopoietic stem cell and B lineage development.Mechanism and regulation of class switch recombination Targeting of AID-mediated sequence diversification to immunoglobulin genes Recombination and transcription of the endogenous Ig heavy chain locus is effected by the Ig heavy chain intronic enhancer core region in the absence of the matrix attachment regions.Direct interactions of OCA-B and TFII-I regulate immunoglobulin heavy-chain gene transcription by facilitating enhancer-promoter communication.Cis-regulatory elements and epigenetic changes control genomic rearrangements of the IgH locus.Position-dependent inhibition of class-switch recombination by PGK-neor cassettes inserted into the immunoglobulin heavy chain constant region locus.AID to overcome the limitations of genomic information by introducing somatic DNA alterations.Homologous elements hs3a and hs3b in the 3' regulatory region of the murine immunoglobulin heavy chain (Igh) locus are both dispensable for class-switch recombination.Dynamic changes in binding of immunoglobulin heavy chain 3' regulatory region to protein factors during class switching.Enhancement of antibody class-switch recombination by the cumulative activity of four separate elements.Mismatch-mediated error prone repair at the immunoglobulin genes.AIDing antibody diversity by error-prone mismatch repair.A primary immunodeficiency characterized by defective immunoglobulin class switch recombination and impaired DNA repair.Replacement of Igamma3 germ-line promoter by Igamma1 inhibits class-switch recombination to IgG3.The 3' end of the heavy chain constant region locus enhances germline transcription and switch recombination of the four gamma genes.RAG2 is regulated differentially in B and T cells by elements 5' of the promoter.Deciphering the importance of the palindromic architecture of the immunoglobulin heavy-chain 3' regulatory region.Sequential activation and distinct functions for distal and proximal modules within the IgH 3' regulatory region Pax5 and linker histone H1 coordinate DNA methylation and histone modifications in the 3' regulatory region of the immunoglobulin heavy chain locus.The IgH 3' regulatory region controls somatic hypermutation in germinal center B cells Immunoglobulin class switch recombination: study through human natural mutants S-S synapsis during class switch recombination is promoted by distantly located transcriptional elements and activation-induced deaminase.Diverse chemicals including aryl hydrocarbon receptor ligands modulate transcriptional activity of the 3'immunoglobulin heavy chain regulatory region.The AhR and NF-κB/Rel Proteins Mediate the Inhibitory Effect of 2,3,7,8-Tetrachlorodibenzo-p-Dioxin on the 3' Immunoglobulin Heavy Chain Regulatory Region.

P2860

Q24291453-B351C841-5445-4794-847F-8C5E76E27B6A Q27692655-F86E5F64-1E94-4B69-AF7F-F852A34436F0 Q28075599-9FA2C620-BFCA-4386-AC61-4DC41D29BBE5 Q28271930-EFD5272B-5D5F-4A45-A1CE-A3A0B8770DBD Q33569786-E3B8C18F-F0B6-4091-8B15-9D3FE362E560 Q33576896-47329CFA-C6D3-4139-A096-49A21DAB70F9 Q33591104-46C65B5C-6F81-493F-BDBD-12910E146A5D Q33741094-1FFB9B7F-0584-449B-9A8D-B6D855F7D529 Q33823918-99BC7280-CB88-433B-9B34-444CBFB46109 Q34033732-CAC78742-BE6A-4ACC-99B3-69B2ABFFD2EF Q34063681-F2E5B50D-893C-4990-B47A-5C20F8C7D50B Q34115234-05458898-788F-49CE-83C2-BE26E242DB19 Q34383957-81FB243B-FFFA-4C80-8B10-DF2942F569B5 Q34586354-C9DD5794-71AE-44F8-811F-BC3D2411E63C Q34733051-1692EFF6-E490-4FAD-A812-6EF682767552 Q34742288-91002E6B-8449-4F8C-AE4C-62B224E7181C Q34764888-CA367DA4-96EF-4BC5-97E0-703055AF99B9 Q34777596-696C82F7-4C18-4655-B737-F97B548891C2 Q34997657-9FACA9A0-871B-48F0-BBF0-FC629D5DEBBF Q35017687-3083F1DF-6F85-4967-B716-07D13EAA651A Q35046836-EAEB322B-747E-4CC9-A87E-9851465B0FFD Q35064395-023D7B82-9B34-47DF-A9E0-5B254F14ED40 Q35068183-BEF6C408-50F3-48CA-A169-9B84F1353AD1 Q35144777-CB2F7E4F-2701-4F62-A725-B3D5F04C50C8 Q35310199-762FF6DF-0228-430A-98E8-DCD8B3436E6B Q35402437-2E7BD574-7886-47EF-80DE-DA5F5011D570 Q35605313-05BBC1DE-D440-4BB0-8C8A-04409C4084EA Q36173942-E76B2689-1EB6-4BFF-A1F2-BBDD8EF5FDC3 Q36229350-EF36E8E2-0713-4853-A04D-2DEA5852B632 Q36300042-0746D680-757E-4494-8882-F4788905CA6B Q36403608-390E86E9-EE4A-4682-88FA-6DEA48457465 Q36553008-DE7BCE18-66DC-4470-9654-B254962DABE9 Q36591272-9457B0E6-274A-4F3B-838A-97D920B777B7 Q36598995-23C6E017-E79C-4884-8F58-441A16C094D9 Q36898970-CF6DE85B-EE80-4645-9403-7C00D6DC9403 Q37055536-EED902D3-36DD-49D8-8452-89889F2BB4C6 Q37140490-4E7B4D2E-305F-4ABE-B108-0CCBF59542C2 Q37164427-5593D1E8-A2AC-44AB-97E1-06C043ED3374 Q37217327-71EE72C6-4736-40F2-9A40-5C1A7F1EF9A9 Q37228121-FA9C326A-099D-4201-9FE2-9D7839AEAEB1

P2860

Class switching in B cells lacking 3' immunoglobulin heavy chain enhancers.

http://www.wikidata.org/entity/Q36404262

description

1998 nî lūn-bûn

@nan

1998年の論文

@ja

1998年学术文章

@wuu

1998年学术文章

@zh-cn

1998年学术文章

@zh-hans

1998年学术文章

@zh-my

1998年学术文章

@zh-sg

1998年學術文章

@yue

1998年學術文章

@zh

1998年學術文章

@zh-hant

name

Class switching in B cells lacking 3' immunoglobulin heavy chain enhancers.

@ast

Class switching in B cells lacking 3' immunoglobulin heavy chain enhancers.

@en

type

label

Class switching in B cells lacking 3' immunoglobulin heavy chain enhancers.

@ast

Class switching in B cells lacking 3' immunoglobulin heavy chain enhancers.

@en

prefLabel

Class switching in B cells lacking 3' immunoglobulin heavy chain enhancers.

@ast

Class switching in B cells lacking 3' immunoglobulin heavy chain enhancers.

@en

P1433

Q36404262-DA661F0A-A212-4B54-B522-21A1ABA123A1

P1476

Q36404262-6439F7BA-CF59-4D66-BD50-A6A2FF43C3D4

P2093

Q36404262-15BD5215-3BA9-4557-AE96-1172B0D67570

Q36404262-3E400734-7D4E-4FAA-BAFC-F51590EC000A

Q36404262-4B478D9B-C426-421A-9247-CA8FEEA0F765

Q36404262-638FDBF4-D7F0-482B-8160-0968F8594EE7

Q36404262-8B561665-23B6-4141-979C-4EE55D50371E

Q36404262-ED9CA55A-86E5-406A-A124-210761B27B56

P2860

Q36404262-0EAC62CC-CD2F-4AD1-9EB7-A1F4172BC4AA

Q36404262-175C3EC1-40B0-42A5-8B08-9723D0924124

Q36404262-1D3AFA19-FA50-4D86-B35C-46E9D7EDB440

Q36404262-209F577F-CCFB-49D9-B450-7519D27EF751

Q36404262-274DBA3F-E11C-4BBC-863C-10C382F16CDD

Q36404262-2C9C040C-4A7D-43F4-9340-7545CAD7F5A8

Q36404262-3326B9FA-FB02-4E54-8CD7-46DB2432A264

Q36404262-3420190C-685D-4474-8AA8-A25ABD47041F

Q36404262-37D2962C-4C48-4B27-B68E-5EE75DAEE4A7

Q36404262-3F510D93-8B2F-4621-BDF4-B8EE9DC130F2

P304

Q36404262-6CDB64B8-88E6-4172-93E3-0DE21C4D9A6D

P31

Q36404262-50E999D6-3FF1-497C-9210-19B85FF8ED46

P356

Q36404262-67E69295-5126-4ABE-8228-BF29704DF66E

P407

Q36404262-D0966F73-8F5E-4889-9895-2977EF13889F

P433

Q36404262-4A88BA8D-8D66-45EA-AC4B-FDECE84274EF

P478

Q36404262-166ED0C1-F2C4-48AB-969C-49BE129D8EAD

P50

Q36404262-4212C7B9-B78B-43AB-A404-E0771A0A92C3

P577

Q36404262-16A99F81-5E3F-4B71-AAA5-822A75AD9679

P5875

Q36404262-680CFF5F-5A0D-403F-A812-F58331CF7922

P698

Q36404262-97FDE8F0-124B-44CF-899F-E3C2ED572F53

P932

Q36404262-52177C22-BBA6-4F32-B9DB-9EE4F5669820

P356

P1433

Journal of Experimental Medicine

P1476

Class switching in B cells lacking 3' immunoglobulin heavy chain enhancers

@en

P2093

F W Alt

http://www.w3.org/2001/XMLSchema#string

J P Manis

http://www.w3.org/2001/XMLSchema#string

L Davidson

http://www.w3.org/2001/XMLSchema#string

M Tian

http://www.w3.org/2001/XMLSchema#string

N van der Stoep

http://www.w3.org/2001/XMLSchema#string

R Ferrini

http://www.w3.org/2001/XMLSchema#string

P2860

Enhancer complexes located downstream of both human immunoglobulin Calpha genes

RAG-2-deficient mice lack mature lymphocytes owing to inability to initiate V(D)J rearrangement

Efficient in vivo manipulation of mouse genomic sequences at the zygote stage

Simplified mammalian DNA isolation procedure

Position-independent, high-level expression of the human beta-globin gene in transgenic mice

Rapid induction of transcription of unrearranged S gamma 1 switch regions in activated murine B cells by interleukin 4.

Immunoglobulin heavy-chain switching may be directed by prior induction of transcripts from constant-region genes.

Synthesis of germ-line gamma 1 immunoglobulin heavy-chain transcripts in resting B cells: induction by interleukin 4 and inhibition by interferon gamma.

Secondary genomic rearrangement events in pre-B cells: VHDJH replacement by a LINE-1 sequence and directed class switching.

Enhancers increase the probability but not the level of gene expression.

P304

1421-1431

http://www.w3.org/2001/XMLSchema#string

P31

scholarly article

P356

10.1084/JEM.188.8.1421

http://www.w3.org/2001/XMLSchema#string

P407

P433

8

http://www.w3.org/2001/XMLSchema#string

P478

188

http://www.w3.org/2001/XMLSchema#string

P50

P577

1998-10-01T00:00:00Z

http://www.w3.org/2001/XMLSchema#dateTime

P5875

13504433

http://www.w3.org/2001/XMLSchema#string

P698

9782119

http://www.w3.org/2001/XMLSchema#string

P932

2213411

http://www.w3.org/2001/XMLSchema#string