RAG-2-deficient mice lack mature lymphocytes owing to inability to initiate V(D)J rearrangement
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The progeroid phenotype of Ku80 deficiency is dominant over DNA-PKCS deficiencyT cell receptor-independent basal signaling via Erk and Abl kinases suppresses RAG gene expressionV(D)J recombination and the evolution of the adaptive immune systemCAST, a novel CD3epsilon-binding protein transducing activation signal for interleukin-2 production in T cellsVprBP binds full-length RAG1 and is required for B-cell development and V(D)J recombination fidelityIncreased Wnt signaling triggers oncogenic conversion of human breast epithelial cells by a Notch-dependent mechanismA THEMIS:SHP1 complex promotes T-cell survivalRch1, a protein that specifically interacts with the RAG-1 recombination-activating proteinBiology of IL-21 and the IL-21 receptorEpithelial V-like antigen (EVA), a novel member of the immunoglobulin superfamily, expressed in embryonic epithelia with a potential role as homotypic adhesion molecule in thymus histogenesisImpaired immunoglobulin gene rearrangement in mice lacking the IL-7 receptorRAG-1 interacts with the repeated amino acid motif of the human homologue of the yeast protein SRP1The gene for severe combined immunodeficiency disease in Athabascan-speaking Native Americans is located on chromosome 10p.Antineutrophil cytoplasmic autoantibodies specific for myeloperoxidase cause glomerulonephritis and vasculitis in micePartial T and B lymphocyte immunodeficiency and predisposition to lymphoma in patients with hypomorphic mutations in ArtemisTYK2 is a key regulator of the surveillance of B lymphoid tumorsThe lymphoid transcription factor LyF-1 is encoded by specific, alternatively spliced mRNAs derived from the Ikaros geneTranscription factor RORĪ± is critical for nuocyte developmentNuocytes represent a new innate effector leukocyte that mediates type-2 immunityLymphocyte-specific compensation for XLF/cernunnos end-joining functions in V(D)J recombinationTOX provides a link between calcineurin activation and CD8 lineage commitmentCancer immunoediting from immune surveillance to immune escapeITM2A is induced during thymocyte selection and T cell activation and causes downregulation of CD8 when overexpressed in CD4(+)CD8(+) double positive thymocytesQuantitative and qualitative changes in V-J alpha rearrangements during mouse thymocytes differentiation: implication for a limited T cell receptor alpha chain repertoireInterference with immunoglobulin (Ig)alpha immunoreceptor tyrosine-based activation motif (ITAM) phosphorylation modulates or blocks B cell development, depending on the availability of an Igbeta cytoplasmic tailOpposing activities of two novel members of the IL-1 ligand family regulate skin inflammationInterleukin 12-dependent interferon gamma production by CD8alpha+ lymphoid dendritic cellsB-cell development fails in the absence of the Pbx1 proto-oncogenePhysical dissociation of the TCR-CD3 complex accompanies receptor ligationThe recombination activation gene 1 (Rag1) is expressed in a subset of zebrafish olfactory neurons but is not essential for axon targeting or amino acid detection.Modeling T cell antigen discrimination based on feedback control of digital ERK responsesHumanized hemato-lymphoid system miceLong-Range Regulation of V(D)J RecombinationStudies of retroviral infection in humanized miceAn immunology primer for computational modelersGene targeting in mice: a reviewLivestock models for exploiting the promise of pluripotent stem cellsRole of the transcription factor Bcl11b in development and lymphomagenesisConcise review: humanized models of tumor immunology in the 21st century: convergence of cancer research and tissue engineeringAntigen-specific suppression and immunological synapse formation by regulatory T cells require the Mst1 kinase
P2860
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P2860
RAG-2-deficient mice lack mature lymphocytes owing to inability to initiate V(D)J rearrangement
description
1992 Õ©ÕøÖÕ”ÕÆÕ”Õ¶Õ« ÕÕ”ÖÕæÕ«Õ¶ Õ°ÖÕ”ÕæÕ”ÖÕ”ÕÆÕøÖÕ”Õ® Õ£Õ«ÕæÕ”ÕÆÕ”Õ¶ ÕµÖ
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@hyw
1992 Õ©Õ¾Õ”ÕÆÕ”Õ¶Õ« Õ“Õ”ÖÕæÕ«Õ¶ Õ°ÖÕ”ÕæÕ”ÖÕ”ÕÆÕ¾Õ”Õ® Õ£Õ«ÕæÕ”ÕÆÕ”Õ¶ Õ°ÕøÕ¤Õ¾Õ”Õ®
@hy
artĆculu cientĆficu espublizĆ”u en 1992
@ast
im MƤrz 1992 verƶffentlichter wissenschaftlicher Artikel
@de
scientific journal article
@en
vedeckĆ½ ÄlĆ”nok (publikovanĆ½ 1992/03/06)
@sk
vÄdeckĆ½ ÄlĆ”nek publikovanĆ½ v roce 1992
@cs
wetenschappelijk artikel (gepubliceerd op 1992/03/06)
@nl
Š½Š°ŃŠŗŠ¾Š²Š° ŃŃŠ°ŃŃŃ, Š¾ŠæŃŠ±Š»ŃŠŗŠ¾Š²Š°Š½Š° Š² Š±ŠµŃŠµŠ·Š½Ń 1992
@uk
Ł
ŁŲ§ŁŲ© Ų¹ŁŁ
ŁŲ© (ŁŲ“Ų±ŲŖ ŁŁ 6-3-1992)
@ar
name
RAG-2-deficient mice lack matu ...... o initiate V(D)J rearrangement
@ast
RAG-2-deficient mice lack matu ...... o initiate V(D)J rearrangement
@en
RAG-2-deficient mice lack matu ...... o initiate V(D)J rearrangement
@nl
type
label
RAG-2-deficient mice lack matu ...... o initiate V(D)J rearrangement
@ast
RAG-2-deficient mice lack matu ...... o initiate V(D)J rearrangement
@en
RAG-2-deficient mice lack matu ...... o initiate V(D)J rearrangement
@nl
prefLabel
RAG-2-deficient mice lack matu ...... o initiate V(D)J rearrangement
@ast
RAG-2-deficient mice lack matu ...... o initiate V(D)J rearrangement
@en
RAG-2-deficient mice lack matu ...... o initiate V(D)J rearrangement
@nl
P2093
P3181
P1433
P1476
RAG-2-deficient mice lack matu ...... o initiate V(D)J rearrangement
@en
P2093
A. M. Stall
E. M. Oltz
G. Rathbun
J. Charron
M. Mendelsohn
V. Stewart
Y. Shinkai
P304
P3181
P356
10.1016/0092-8674(92)90029-C
P407
P577
1992-03-06T00:00:00Z