CD40-CD40 ligand interactions in vivo regulate migration of antigen-bearing dendritic cells from the skin to draining lymph nodes.
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Dendritic cells induce peripheral T cell unresponsiveness under steady state conditions in vivoMMP19 is essential for T cell development and T cell-mediated cutaneous immune responsesNanoparticle-delivered multimeric soluble CD40L DNA combined with Toll-Like Receptor agonists as a treatment for melanoma.Characterization of the CD154-positive and CD40-positive cellular subsets required for pathogenesis in retrovirus-induced murine immunodeficiency.In vivo maturation and migration of dendritic cells.A positive regulatory role for Cbl family proteins in tumor necrosis factor-related activation-induced cytokine (trance) and CD40L-mediated Akt activation.CD40 stimulation leads to effective therapy of CD40(-) tumors through induction of strong systemic cytotoxic T lymphocyte immunity.Dendritic cell maturation in active immunotherapy strategies.Immunotargeting with CD154 (CD40 ligand) enhances DNA vaccine responses in ducks.Some interfaces of dendritic cell biology.Dendritic cells: regulators of alloimmunity and opportunities for tolerance induction.CD40/CD154 interactions are required for the optimal maturation of skin-derived APCs and the induction of helminth-specific IFN-gamma but not IL-4.Immunotherapy of high-risk acute leukemia with a recipient (autologous) vaccine expressing transgenic human CD40L and IL-2 after chemotherapy and allogeneic stem cell transplantation.In the absence of CD154, administration of interleukin-12 restores Th1 responses but not protective immunity to Schistosoma mansoniEBNA1-specific CD4+ T cells in healthy carriers of Epstein-Barr virus are primarily Th1 in functionCD4 memory T cells survive and proliferate but fail to differentiate in the absence of CD40IRF4 promotes cutaneous dendritic cell migration to lymph nodes during homeostasis and inflammation.Complementary role of CD4+ T cells and secondary lymphoid tissues for cross-presentation of tumor antigen to CD8+ T cells.Uncoupling of proliferative potential and gain of effector function by CD8(+) T cells responding to self-antigens.The linkage of innate to adaptive immunity via maturing dendritic cells in vivo requires CD40 ligation in addition to antigen presentation and CD80/86 costimulationCombinational adenovirus-mediated gene therapy and dendritic cell vaccine in combating well-established tumors.Retinoic acid promotes mouse splenic B cell surface IgG expression and maturation stimulated by CD40 and IL-4.Rhamnogalacturonan II is a Toll-like receptor 4 agonist that inhibits tumor growth by activating dendritic cell-mediated CD8+ T cells.Dendritic cells serve as a "Trojan horse" for oncolytic adenovirus delivery in the treatment of mouse prostate cancerImmunological mechanisms of contact hypersensitivity in mice.Transfection and ligation of CD40 in human oral keratinocytes affect proliferation, adhesion and migration but not apoptosis in vitro.Coexpression of CD40L and CD70 by semiallogenic tumor cells induces anti-tumor immunity.Concurrent delivery of tumor antigens and activation signals to dendritic cells by irradiated CD40 ligand-transfected tumor cells resulted in efficient activation of specific CD8+ T cells.CD40 is necessary for activation of naïve T cells by a dendritic cell line in vivo but not in vitro.Neuroinvasion by scrapie following inoculation via the skin is independent of migratory Langerhans cells.Inflammatory conditions distinctively alter immunological functions of Langerhans-like cells and dendritic cells in vitro.Overexpression of CD40 ligand in murine epidermis results in chronic skin inflammation and systemic autoimmunity.Systemic treatment with anti-CD40 antibody stimulates Langerhans cell migration from the skin.Intratumoral administration of immature dendritic cells following the adenovirus vector encoding CD40 ligand elicits significant regression of established myeloma.CD8(+) T cells responding to alveolar self-antigen lack CD25 expression and fail to precipitate autoimmunity.Loss of CD154 impairs the Th2 extrafollicular plasma cell response but not early T cell proliferation and interleukin-4 induction.Inability to induce tolerance through direct antigen presentation.Modulation of immune responses to bovine herpesvirus-1 in cattle by immunization with a DNA vaccine encoding glycoprotein D as a fusion protein with bovine CD154.Skin antigens in the steady state are trafficked to regional lymph nodes by transforming growth factor-beta1-dependent cells.
P2860
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P2860
CD40-CD40 ligand interactions in vivo regulate migration of antigen-bearing dendritic cells from the skin to draining lymph nodes.
description
2000 nî lūn-bûn
@nan
2000年の論文
@ja
2000年学术文章
@wuu
2000年学术文章
@zh-cn
2000年学术文章
@zh-hans
2000年学术文章
@zh-my
2000年学术文章
@zh-sg
2000年學術文章
@yue
2000年學術文章
@zh
2000年學術文章
@zh-hant
name
CD40-CD40 ligand interactions ...... skin to draining lymph nodes.
@ast
CD40-CD40 ligand interactions ...... skin to draining lymph nodes.
@en
type
label
CD40-CD40 ligand interactions ...... skin to draining lymph nodes.
@ast
CD40-CD40 ligand interactions ...... skin to draining lymph nodes.
@en
prefLabel
CD40-CD40 ligand interactions ...... skin to draining lymph nodes.
@ast
CD40-CD40 ligand interactions ...... skin to draining lymph nodes.
@en
P2093
P2860
P356
P1476
CD40-CD40 ligand interactions ...... skin to draining lymph nodes.
@en
P2093
A M Moodycliffe
J Walterscheid
L Flores-Romo
M L Kripke
S E Ullrich
V Shreedhar
P2860
P304
P356
10.1084/JEM.191.11.2011
P407
P577
2000-06-01T00:00:00Z