Functional properties of cardiac L-type calcium channels transiently expressed in HEK293 cells. Roles of alpha 1 and beta subunits.
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Biophysical properties, pharmacology, and modulation of human, neuronal L-type (alpha(1D), Ca(V)1.3) voltage-dependent calcium currentsIon Channels in the HeartThe neuronal beta 4 subunit increases the unitary conductance of L-type voltage-gated calcium channels in PC12 cellsExcitatory but not inhibitory synaptic transmission is reduced in lethargic (Cacnb4(lh)) and tottering (Cacna1atg) mouse thalamiPosthearing Ca(2+) currents and their roles in shaping the different modes of firing of spiral ganglion neuronsMultiple modulation pathways of calcium channel activity by a beta subunit. Direct evidence of beta subunit participation in membrane trafficking of the alpha1C subunit.Topology of the P segments in the sodium channel pore revealed by cysteine mutagenesisRecovery of Ca2+ current, charge movements, and Ca2+ transients in myotubes deficient in dihydropyridine receptor beta 1 subunit transfected with beta 1 cDNA.The beta subunit increases Ca2+ currents and gating charge movements of human cardiac L-type Ca2+ channels.Ca2+ current activation rate correlates with alpha 1 subunit density.Reduced Ca2+ current, charge movement, and absence of Ca2+ transients in skeletal muscle deficient in dihydropyridine receptor beta 1 subunit.Molecular origin of the L-type Ca2+ current of skeletal muscle myotubes selectively deficient in dihydropyridine receptor beta1a subunitDifferential regulation of skeletal muscle L-type Ca2+ current and excitation-contraction coupling by the dihydropyridine receptor beta subunit.Stac adaptor proteins regulate trafficking and function of muscle and neuronal L-type Ca2+ channelsEffect of serum withdrawal on the contribution of L-type calcium channels (CaV1.2) to intracellular Ca2+ responses and chemotaxis in cultured human vascular smooth muscle cellsCalcium and arrhythmogenesis.Regulation of a proteinaceous elicitor-induced Ca2+ influx and production of phytoalexins by a putative voltage-gated cation channel, OsTPC1, in cultured rice cells.Regulation of maximal open probability is a separable function of Ca(v)beta subunit in L-type Ca2+ channel, dependent on NH2 terminus of alpha1C (Ca(v)1.2alpha).Redox modulation of L-type calcium channels in ferret ventricular myocytes. Dual mechanism regulation by nitric oxide and S-nitrosothiols.Structural regions of the cardiac Ca channel alpha subunit involved in Ca-dependent inactivation.The Na+/Ca2+ exchange inhibitor 2-(2-(4-(4-nitrobenzyloxy)phenyl)ethyl)isothiourea methanesulfonate (KB-R7943) also blocks ryanodine receptors type 1 (RyR1) and type 2 (RyR2) channelsFunctional interaction of auxiliary subunits and synaptic proteins with Ca(v)1.3 may impart hair cell Ca2+ current properties.Current modulation and membrane targeting of the calcium channel alpha1C subunit are independent functions of the beta subunit.Four conductance levels of cloned cardiac L-type Ca2+ channel alpha1 and alpha1/beta subunits.Ethanol regulates calcium channel subunits by protein kinase C delta -dependent and -independent mechanisms.Endogenous calcium channels in human embryonic kidney (HEK293) cells.Direct measurement of single-channel Ca(2+) currents in bullfrog hair cells reveals two distinct channel subtypes.Influence of channel subunit composition on L-type Ca2+ current kinetics and cardiac wave stability.Identification of a second region of the beta-subunit involved in regulation of calcium channel inactivation.Facilitation by the beta2a subunit of pore openings in cardiac Ca2+ channels.Membrane targeting of L-type calcium channels. Role of palmitoylation in the subcellular localization of the beta2a subunit.The expression of endogenous voltage-gated potassium channels in HEK293 cells is affected by culture conditions.
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P2860
Functional properties of cardiac L-type calcium channels transiently expressed in HEK293 cells. Roles of alpha 1 and beta subunits.
description
1995 nî lūn-bûn
@nan
1995年の論文
@ja
1995年学术文章
@wuu
1995年学术文章
@zh-cn
1995年学术文章
@zh-hans
1995年学术文章
@zh-my
1995年学术文章
@zh-sg
1995年學術文章
@yue
1995年學術文章
@zh
1995年學術文章
@zh-hant
name
Functional properties of cardi ...... of alpha 1 and beta subunits.
@ast
Functional properties of cardi ...... of alpha 1 and beta subunits.
@en
type
label
Functional properties of cardi ...... of alpha 1 and beta subunits.
@ast
Functional properties of cardi ...... of alpha 1 and beta subunits.
@en
prefLabel
Functional properties of cardi ...... of alpha 1 and beta subunits.
@ast
Functional properties of cardi ...... of alpha 1 and beta subunits.
@en
P2860
P356
P1476
Functional properties of cardi ...... s of alpha 1 and beta subunits
@en
P2093
P2860
P304
P356
10.1085/JGP.105.2.289
P577
1995-02-01T00:00:00Z