Independence and cooperativity in rearrangements of a potassium channel voltage sensor revealed by single subunit fluorescence.
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Strong cooperativity between subunits in voltage-gated proton channelsThe opening of the two pores of the Hv1 voltage-gated proton channel is tuned by cooperativityBinding of a gating modifier toxin induces intersubunit cooperativity early in the Shaker K channel's activation pathwayMechanosensitive gating of Kv channelsConformational changes and slow dynamics through microsecond polarized atomistic molecular simulation of an integral Kv1.2 ion channelIndependent movement of the voltage sensors in KV2.1/KV6.4 heterotetramersWhole cell patch clamp recording performed on a planar glass chipThe ion channel inverse problem: neuroinformatics meets biophysics.S1 constrains S4 in the voltage sensor domain of Kv7.1 K+ channels.Use of voltage clamp fluorimetry in understanding potassium channel gating: a review of Shaker fluorescence data.Separation of heteromeric potassium channel Kcv towards probing subunit composition-regulated ion permeation and gating.Stepwise contribution of each subunit to the cooperative activation of BK channels by Ca2+.A physical model of potassium channel activation: from energy landscape to gating kineticsElectrostatic model of S4 motion in voltage-gated ion channels.Detecting rearrangements of shaker and NaChBac in real-time with fluorescence spectroscopy in patch-clamped mammalian cells.Coupled motions between pore and voltage-sensor domains: a model for Shaker B, a voltage-gated potassium channelStructural rearrangements in single ion channels detected optically in living cellsProbability fluxes and transition paths in a Markovian model describing complex subunit cooperativity in HCN2 channelsThe cooperative voltage sensor motion that gates a potassium channel.Voltage-dependent conformational changes in human Ca(2+)- and voltage-activated K(+) channel, revealed by voltage-clamp fluorometry.Intra- and intersubunit cooperativity in activation of BK channels by Ca2+beta-Scorpion toxin modifies gating transitions in all four voltage sensors of the sodium channelKinetic relationship between the voltage sensor and the activation gate in spHCN channelsFast and slow voltage sensor movements in HERG potassium channels.S4 movement in a mammalian HCN channel.Coupling interactions between voltage sensors of the sodium channel as revealed by site-specific measurements.Constitutive activation of the Shaker Kv channel.Immobilizing the moving parts of voltage-gated ion channelsStabilizing the closed S6 gate in the Shaker Kv channel through modification of a hydrophobic seal.A gastropod toxin selectively slows early transitions in the Shaker K channel's activation pathwayLocalization of the activation gate of a voltage-gated Ca2+ channel.Dynamics of internal pore opening in K(V) channels probed by a fluorescent unnatural amino acid.Modeling subunit cooperativity in opening of tetrameric ion channels.Direct analysis of cooperativity in multisubunit allosteric proteins.Local anesthetics disrupt energetic coupling between the voltage-sensing segments of a sodium channel.Molecular recognition and self-assembly special feature: Calix[4]arene-based conical-shaped ligands for voltage-dependent potassium channels.Emerging approaches to probing ion channel structure and function.Molecular mechanism of voltage sensor movements in a potassium channel.Uncooperative voltage sensors.Interactive domains between pore loops of the yeast K+ channel TOK1 associate with extracellular K+ sensitivity.
P2860
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P2860
Independence and cooperativity in rearrangements of a potassium channel voltage sensor revealed by single subunit fluorescence.
description
2000 nî lūn-bûn
@nan
2000年の論文
@ja
2000年学术文章
@wuu
2000年学术文章
@zh-cn
2000年学术文章
@zh-hans
2000年学术文章
@zh-my
2000年学术文章
@zh-sg
2000年學術文章
@yue
2000年學術文章
@zh
2000年學術文章
@zh-hant
name
Independence and cooperativity ...... y single subunit fluorescence.
@ast
Independence and cooperativity ...... y single subunit fluorescence.
@en
type
label
Independence and cooperativity ...... y single subunit fluorescence.
@ast
Independence and cooperativity ...... y single subunit fluorescence.
@en
prefLabel
Independence and cooperativity ...... y single subunit fluorescence.
@ast
Independence and cooperativity ...... y single subunit fluorescence.
@en
P2860
P356
P1476
Independence and cooperativity ...... y single subunit fluorescence.
@en
P2093
E Y Isacoff
L M Mannuzzu
P2860
P304
P356
10.1085/JGP.115.3.257
P577
2000-03-01T00:00:00Z