Trapping of a methanesulfonanilide by closure of the HERG potassium channel activation gate.
about
Role of voltage-gated sodium, potassium and calcium channels in the development of cocaine-associated cardiac arrhythmiasThe antipsychotic drug chlorpromazine inhibits HERG potassium channelsIn silico analysis of conformational changes induced by mutation of aromatic binding residues: consequences for drug binding in the hERG K+ channelMechanistic Insight into Human ether-a-go-go-related Gene (hERG) K+ Channel Deactivation Gating from the Solution Structure of the EAG DomainA structural basis for drug-induced long QT syndromeDistinct mechanisms of block of Kv1.5 channels by tertiary and quaternary amine clofilium compounds.Toxicologic myocardial sensitization.Inherited and acquired vulnerability to ventricular arrhythmias: cardiac Na+ and K+ channels.Discovery of a novel activator of KCNQ1-KCNE1 K channel complexes.Proline scan of the HERG channel S6 helix reveals the location of the intracellular pore gate.A multiscale computational modelling approach predicts mechanisms of female sex risk in the setting of arousal-induced arrhythmias.HERG1 channelopathiesPosition of aromatic residues in the S6 domain, not inactivation, dictates cisapride sensitivity of HERG and eag potassium channels.BeKm-1 is a HERG-specific toxin that shares the structure with ChTx but the mechanism of action with ErgTx1Identification and characterization of a compound that protects cardiac tissue from human Ether-à-go-go-related gene (hERG)-related drug-induced arrhythmiasAtALMT1, which encodes a malate transporter, is identified as one of several genes critical for aluminum tolerance in Arabidopsis.Cellular basis of drug-induced torsades de pointesCocaine-induced channelopathies: emerging evidence on the multiple mechanisms of sudden death.The search is on for the voltage sensor-to-gate coupling.Inhibition of hEAG1 and hERG1 potassium channels by clofilium and its tertiary analogue LY97241.Inhibition of cardiac HERG currents by the DNA topoisomerase II inhibitor amsacrine: mode of actionAntiarrhythmic drugs: new agents and evolving concepts.Stereoselective Inhibition of the hERG1 Potassium Channel.Drug binding to HERG channels: evidence for a 'non-aromatic' binding site for fluvoxamineBlockade of HERG human K+ channels and IKr of guinea-pig cardiomyocytes by the antipsychotic drug clozapineAntiarrhythmic drugs: past, present and future.hERG potassium channel blockade by the HCN channel inhibitor bradycardic agent ivabradine.Channel structure and drug-induced cardiac arrhythmias.Suppression of phosphoinositide 3-kinase signaling and alteration of multiple ion currents in drug-induced long QT syndromeStructural and functional role of the extracellular s5-p linker in the HERG potassium channelPharmacogenetic issues in thorough QT trials.Molecular mechanisms for drug interactions with hERG that cause long QT syndrome.The hERG potassium channel as a therapeutic target.Mechanism of HERG potassium channel inhibition by tetra-n-octylammonium bromide and benzethonium chloride.hERG gating microdomains defined by S6 mutagenesis and molecular modeling.The organic cation transporter, OCTN1, expressed in the human heart, potentiates antagonism of the HERG potassium channelRole of the pH in state-dependent blockade of hERG currents.Transfer of rolf S3-S4 linker to HERG eliminates activation gating but spares inactivation.Physiological properties of hERG 1a/1b heteromeric currents and a hERG 1b-specific mutation associated with Long-QT syndrome.The emerging role of antiarrhythmic compounds with atrial selectivity in the management of atrial fibrillation.
P2860
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P2860
Trapping of a methanesulfonanilide by closure of the HERG potassium channel activation gate.
description
2000 nî lūn-bûn
@nan
2000年の論文
@ja
2000年学术文章
@wuu
2000年学术文章
@zh-cn
2000年学术文章
@zh-hans
2000年学术文章
@zh-my
2000年学术文章
@zh-sg
2000年學術文章
@yue
2000年學術文章
@zh
2000年學術文章
@zh-hant
name
Trapping of a methanesulfonani ...... ssium channel activation gate.
@ast
Trapping of a methanesulfonani ...... ssium channel activation gate.
@en
type
label
Trapping of a methanesulfonani ...... ssium channel activation gate.
@ast
Trapping of a methanesulfonani ...... ssium channel activation gate.
@en
prefLabel
Trapping of a methanesulfonani ...... ssium channel activation gate.
@ast
Trapping of a methanesulfonani ...... ssium channel activation gate.
@en
P2860
P356
P1476
Trapping of a methanesulfonani ...... assium channel activation gate
@en
P2093
M C Sanguinetti
P2860
P304
P356
10.1085/JGP.115.3.229
P577
2000-03-01T00:00:00Z