Physiological properties of hERG 1a/1b heteromeric currents and a hERG 1b-specific mutation associated with Long-QT syndrome. - Wikidata - wikimedia - TriplyDB

Physiological properties of hERG 1a/1b heteromeric currents and a hERG 1b-specific mutation associated with Long-QT syndrome.

Physiological properties of hERG 1a/1b heteromeric currents and a hERG 1b-specific mutation associated with Long-QT syndrome.

http://www.wikidata.org/entity/Q37385262

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Rescue of aberrant gating by a genetically encoded PAS (Per-Arnt-Sim) domain in several long QT syndrome mutant human ether-á-go-go-related gene potassium channels A recombinant N-terminal domain fully restores deactivation gating in N-truncated and long QT syndrome mutant hERG potassium channels Computer-based prediction of the drug proarrhythmic effect: problems, issues, known and suspected challenges Autonomous beating rate adaptation in human stem cell-derived cardiomyocytes.Mechanistic Insight into Human ether-a-go-go-related Gene (hERG) K+ Channel Deactivation Gating from the Solution Structure of the EAG Domain Computational cardiology: how computer simulations could be used to develop new therapies and advance existing ones Molecular Cloning and Functional Expression of the Equine K+ Channel KV11.1 (Ether à Go-Go-Related/KCNH2 Gene) and the Regulatory Subunit KCNE2 from Equine Myocardium Antiarrhythmics cure brain arrhythmia: The imperativeness of subthalamic ERG K+ channels in parkinsonian discharges.Cardiac models in drug discovery and development: a review.Combined gating and trafficking defect in Kv11.1 manifests as a malignant long QT syndrome phenotype in a large Danish p.F29L founder family.Differential expression of hERG1 channel isoforms reproduces properties of native I(Kr) and modulates cardiac action potential characteristics.HERG1 channelopathies Properties of WT and mutant hERG K(+) channels expressed in neonatal mouse cardiomyocytes.hERG 1b is critical for human cardiac repolarization Sig1R protein regulates hERG channel expression through a post-translational mechanism in leukemic cells.Recapitulation of an ion channel IV curve using frequency components hERG1a N-terminal eag domain-containing polypeptides regulate homomeric hERG1b and heteromeric hERG1a/hERG1b channels: a possible mechanism for long QT syndrome.hERG potassium channel blockade by the HCN channel inhibitor bradycardic agent ivabradine.The virtual heart as a platform for screening drug cardiotoxicity.Reduced response to IKr blockade and altered hERG1a/1b stoichiometry in human heart failure The eag domain regulates hERG channel inactivation gating via a direct interaction.Computational assessment of drug-induced effects on the electrocardiogram: from ion channel to body surface potentials Dominant negative consequences of a hERG 1b-specific mutation associated with intrauterine fetal death.Cotranslational association of mRNA encoding subunits of heteromeric ion channels.Computational approaches to understand cardiac electrophysiology and arrhythmias.Enhancement of hERG channel activity by scFv antibody fragments targeted to the PAS domain Endocytic control of ion channel density as a target for cardiovascular disease.Long QT syndrome-associated mutations in intrauterine fetal death.Using computational modeling to predict arrhythmogenesis and antiarrhythmic therapy.The voltage-gated channel accessory protein KCNE2: multiple ion channel partners, multiple ways to long QT syndrome.Cardiac potassium channel subtypes: new roles in repolarization and arrhythmia.The enigmatic cytoplasmic regions of KCNH channels.hERG subunit composition determines differential drug sensitivity.Proliferative Role of Kv11 Channels in Murine Arteries.Molecular Pathophysiology of Congenital Long QT Syndrome.Effects of Temperature on Heteromeric Kv11.1a/1b and Kv11.3 Channels Cysteine 723 in the C-linker segment confers oxidative inhibition of hERG1 potassium channels.hERG1a/1b heteromeric currents exhibit amplified attenuation of inactivation in variant 1 short QT syndrome.Functional expression of potassium channels in cardiomyocytes derived from embryonic stem cells.Cysteines control the N- and C-linker-dependent gating of KCNH1 potassium channels.

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Physiological properties of hERG 1a/1b heteromeric currents and a hERG 1b-specific mutation associated with Long-QT syndrome.

http://www.wikidata.org/entity/Q37385262

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article científic

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article scientifique

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articolo scientifico

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bilimsel makale

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scientific article published on 05 September 2008

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vedecký článok

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vetenskaplig artikel

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vědecký článek

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Physiological properties of hE ...... ociated with Long-QT syndrome.

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Physiological properties of hE ...... ociated with Long-QT syndrome.

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Physiological properties of hE ...... ociated with Long-QT syndrome.

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Physiological properties of hE ...... ociated with Long-QT syndrome.

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Physiological properties of hE ...... ociated with Long-QT syndrome.

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Physiological properties of hE ...... ociated with Long-QT syndrome.

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CIRCRESAHA.108.185249

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Circulation Research

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Physiological properties of hE ...... ociated with Long-QT syndrome.

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David J Tester

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Gail A Robertson

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Harinath Sale

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Jia-Qiang He

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Jinling Wang

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Michael J Ackerman

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Pallavi Phartiyal

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Thomas J O'Hara

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Yoram Rudy

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P2860

A mechanistic link between an inherited and an acquired cardiac arrhythmia: HERG encodes the IKr potassium channel

A molecular basis for cardiac arrhythmia: HERG mutations cause long QT syndrome

HERG, a human inward rectifier in the voltage-gated potassium channel family

The inward rectification mechanism of the HERG cardiac potassium channel

A comparison of currents carried by HERG, with and without coexpression of MiRP1, and the native rapid delayed rectifier current. Is MiRP1 the missing link?

Crystal structure of a mammalian voltage-dependent Shaker family K+ channel

Prevalence of long-QT syndrome gene variants in sudden infant death syndrome

A structural basis for drug-induced long QT syndrome

Properties of HERG channels stably expressed in HEK 293 cells studied at physiological temperature

Two isoforms of the mouse ether-a-go-go-related gene coassemble to form channels with properties similar to the rapidly activating component of the cardiac delayed rectifier K+ current

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10.1161/CIRCRESAHA.108.185249

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7

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