Lapatinib and obatoclax kill breast cancer cells through reactive oxygen species-dependent endoplasmic reticulum stress.
about
The BH3 Mimetic Obatoclax Accumulates in Lysosomes and Causes Their AlkalinizationPDE5 inhibitors enhance the lethality of standard of care chemotherapy in pediatric CNS tumor cells.Lapatinib induces autophagic cell death and inhibits growth of human hepatocellular carcinoma.Afatinib and its encapsulated polymeric micelles inhibits HER2-overexpressed colorectal tumor cell growth in vitro and in vivoSorafenib/regorafenib and lapatinib interact to kill CNS tumor cells.Piperlongumine selectively kills hepatocellular carcinoma cells and preferentially inhibits their invasion via ROS-ER-MAPKs-CHOP.Lapatinib induces autophagic cell death and differentiation in acute myeloblastic leukemiaSorafenib/regorafenib and phosphatidyl inositol 3 kinase/thymoma viral proto-oncogene inhibition interact to kill tumor cells.Survival of HER2-Positive Breast Cancer Cells: Receptor Signaling to Apoptotic Control Centers.Histone deacetylase inhibitors restore toxic BH3 domain protein expression in anoikis-resistant mammary and brain cancer stem cells, thereby enhancing the response to anti-ERBB1/ERBB2 therapy.Phosphodiesterase 5 inhibitors enhance chemotherapy killing in gastrointestinal/genitourinary cancer cells.The putative BH3 mimetic S1 sensitizes leukemia to ABT-737 by increasing reactive oxygen species, inducing endoplasmic reticulum stress, and upregulating the BH3-only protein NOXA.Smac mimetic LCL161 overcomes protective ER stress induced by obatoclax, synergistically causing cell death in multiple myeloma.Bisdemethoxycurcumin exerts pro-apoptotic effects in human pancreatic adenocarcinoma cells through mitochondrial dysfunction and a GRP78-dependent pathway.A novel BH3 mimetic efficiently induces apoptosis in melanoma cells through direct binding to anti-apoptotic Bcl-2 family proteins, including phosphorylated Mcl-1.Inhibition of JNK3 promotes apoptosis induced by BH3 mimetic S1 in chemoresistant human ovarian cancer cells.Obatoclax induces G1/G0-phase arrest via p38/p21(waf1/Cip1) signaling pathway in human esophageal cancer cells.Everolimus enhances cellular cytotoxicity of lapatinib via the eukaryotic elongation factor-2 kinase pathway in nasopharyngeal carcinoma cells.PTK6 regulates growth and survival of endocrine therapy-resistant ER+ breast cancer cells.Mephebrindole, a synthetic indole analog coordinates the crosstalk between p38MAPK and eIF2α/ATF4/CHOP signalling pathways for induction of apoptosis in human breast carcinoma cells.RFX-1-dependent activation of SHP-1 inhibits STAT3 signaling in hepatocellular carcinoma cells.
P2860
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P2860
Lapatinib and obatoclax kill breast cancer cells through reactive oxygen species-dependent endoplasmic reticulum stress.
description
2012 nî lūn-bûn
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2012年の論文
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2012年学术文章
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2012年学术文章
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2012年学术文章
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2012年学术文章
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name
Lapatinib and obatoclax kill b ...... endoplasmic reticulum stress.
@ast
Lapatinib and obatoclax kill b ...... endoplasmic reticulum stress.
@en
type
label
Lapatinib and obatoclax kill b ...... endoplasmic reticulum stress.
@ast
Lapatinib and obatoclax kill b ...... endoplasmic reticulum stress.
@en
prefLabel
Lapatinib and obatoclax kill b ...... endoplasmic reticulum stress.
@ast
Lapatinib and obatoclax kill b ...... endoplasmic reticulum stress.
@en
P2093
P2860
P356
P1476
Lapatinib and obatoclax kill b ...... endoplasmic reticulum stress.
@en
P2093
Hossein Hamed
Laurence Booth
Nichola Cruickshanks
Steven Grant
P2860
P304
P356
10.1124/MOL.112.081539
P50
P577
2012-09-18T00:00:00Z