The accessory subunit of mtDNA polymerase shares structural homology with aminoacyl-tRNA synthetases: implications for a dual role as a primer recognition factor and processivity clamp.
about
Protein sequences conserved in prokaryotic aminoacyl-tRNA synthetases are important for the activity of the processivity factor of human mitochondrial DNA polymeraseA human mitochondrial transcription factor is related to RNA adenine methyltransferases and binds S-adenosylmethionineThe role of protein structure in genomics.Human APE2 protein is mostly localized in the nuclei and to some extent in the mitochondria, while nuclear APE2 is partly associated with proliferating cell nuclear antigenMitochondrial DNA replication: a PrimPol perspective.Each monomer of the dimeric accessory protein for human mitochondrial DNA polymerase has a distinct role in conferring processivity.Aminoacyl-tRNA synthetases database Y2KA mechanistic view of human mitochondrial DNA polymerase gamma: providing insight into drug toxicity and mitochondrial diseaseFunctional analysis of H. sapiens DNA polymerase gamma spacer mutation W748S with and without common variant E1143G.In vivo functional analysis of the human mitochondrial DNA polymerase POLG expressed in cultured human cells.The highly compact structure of the mitochondrial DNA polymerase genomic region of Drosophila melanogaster: functional and evolutionary implications.The accessory subunit of DNA polymerase gamma is essential for mitochondrial DNA maintenance and development in Drosophila melanogasterDefects of mitochondrial DNA replication.Mutations of mitochondrial DNA polymerase gammaA are a frequent cause of autosomal dominant or recessive progressive external ophthalmoplegia.DNA binding properties of human pol gammaB.MGME1 processes flaps into ligatable nicks in concert with DNA polymerase γ during mtDNA replication.Biochemical analysis of human POLG2 variants associated with mitochondrial disease.Evolution of the metazoan mitochondrial replicase.Muscle-specific overexpression of the catalytic subunit of DNA polymerase γ induces pupal lethality in Drosophila melanogaster.A novel processive mechanism for DNA synthesis revealed by structure, modeling and mutagenesis of the accessory subunit of human mitochondrial DNA polymeraseNumber matters: control of mammalian mitochondrial DNA copy number.Animal Mitochondrial DNA Replication.Pathological ribonuclease H1 causes R-loop depletion and aberrant DNA segregation in mitochondria.The accessory subunit of mitochondrial DNA polymerase gamma determines the DNA content of mitochondrial nucleoids in human cultured cells.A genomics method to identify pathogenicity-related proteins. Application to aminoacyl-tRNA synthetase-like proteins.Replicating animal mitochondrial DNA.Differential regulation of the catalytic and accessory subunit genes of Drosophila mitochondrial DNA polymerase.Crystal structure of a eukaryote/archaeon-like protyl-tRNA synthetase and its complex with tRNAPro(CGG)RECQL4 and p53 potentiate the activity of polymerase γ and maintain the integrity of the human mitochondrial genome.
P2860
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P2860
The accessory subunit of mtDNA polymerase shares structural homology with aminoacyl-tRNA synthetases: implications for a dual role as a primer recognition factor and processivity clamp.
description
1999 nî lūn-bûn
@nan
1999年の論文
@ja
1999年学术文章
@wuu
1999年学术文章
@zh-cn
1999年学术文章
@zh-hans
1999年学术文章
@zh-my
1999年学术文章
@zh-sg
1999年學術文章
@yue
1999年學術文章
@zh
1999年學術文章
@zh-hant
name
The accessory subunit of mtDNA ...... factor and processivity clamp.
@ast
The accessory subunit of mtDNA ...... factor and processivity clamp.
@en
type
label
The accessory subunit of mtDNA ...... factor and processivity clamp.
@ast
The accessory subunit of mtDNA ...... factor and processivity clamp.
@en
prefLabel
The accessory subunit of mtDNA ...... factor and processivity clamp.
@ast
The accessory subunit of mtDNA ...... factor and processivity clamp.
@en
P2093
P2860
P356
P1476
The accessory subunit of mtDNA ...... factor and processivity clamp.
@en
P2093
P2860
P304
P356
10.1073/PNAS.96.17.9527
P407
P577
1999-08-01T00:00:00Z