Genetics of Parkinson disease: paradigm shifts and future prospects.
about
Absence of Ret signaling in mice causes progressive and late degeneration of the nigrostriatal systemWeb-based genome-wide association study identifies two novel loci and a substantial genetic component for Parkinson's diseaseThe importance of integrating basic and clinical research toward the development of new therapies for Huntington diseaseA genomic pathway approach to a complex disease: axon guidance and Parkinson diseaseImpaired dopaminergic neurotransmission and microtubule-associated protein tau alterations in human LRRK2 transgenic miceFunctional alteration of PARL contributes to mitochondrial dysregulation in Parkinson's diseaseIdentification of potential protein interactors of Lrrk2Characterisation of a novel NR4A2 mutation in Parkinson's disease brainPINK1 protects against oxidative stress by phosphorylating mitochondrial chaperone TRAP1Membrane localization of LRRK2 is associated with increased formation of the highly active LRRK2 dimer and changes in its phosphorylationThe G2385R variant of leucine-rich repeat kinase 2 associated with Parkinson's disease is a partial loss-of-function mutationA Nurr1/CoREST pathway in microglia and astrocytes protects dopaminergic neurons from inflammation-induced deathRole of autophagy in G2019S-LRRK2-associated neurite shortening in differentiated SH-SY5Y cellsAneuploidy: cells losing their balanceSCFCdc4 acts antagonistically to the PGC-1alpha transcriptional coactivator by targeting it for ubiquitin-mediated proteolysisEpigenetic Research of Neurodegenerative Disorders Using Patient iPSC-Based ModelsFriends or Foes: Matrix Metalloproteinases and Their Multifaceted Roles in Neurodegenerative DiseasesBiophysical characterization of α-synuclein and its controversial structurePathogenesis of synaptic degeneration in Alzheimer's disease and Lewy body diseaseTargeting Hsp90/Hsp70-based protein quality control for treatment of adult onset neurodegenerative diseasesKnockdown of Hsc70-5/mortalin induces loss of synaptic mitochondria in a Drosophila Parkinson's disease modelParkin promotes proteasomal degradation of p62: implication of selective vulnerability of neuronal cells in the pathogenesis of Parkinson's diseaseStructure of the Roc–COR domain tandem of C. tepidum, a prokaryotic homologue of the human LRRK2 Parkinson kinaseGDNF-Ret signaling in midbrain dopaminergic neurons and its implication for Parkinson diseaseGene-environment interactions: key to unraveling the mystery of Parkinson's diseaseDEGAS: de novo discovery of dysregulated pathways in human diseasesGDNF-transfected macrophages produce potent neuroprotective effects in Parkinson's disease mouse modelA mouse forward genetics screen identifies LISTERIN as an E3 ubiquitin ligase involved in neurodegeneration.DNAJC13 mutations in Parkinson diseaseModelling idiopathic Parkinson disease as a complex illness can inform incidence rate in healthy adults: the PREDIGT scoreDisease-toxicant interactions in Parkinson's disease neuropathologyThe effects of oxidative stress on parkin and other E3 ligases.Elevated alpha-synuclein mRNA levels in individual UV-laser-microdissected dopaminergic substantia nigra neurons in idiopathic Parkinson's disease.High-throughput homogeneous mass cleave assay technology for the diagnosis of autosomal recessive Parkinson's diseaseBiophysics of Parkinson's disease: structure and aggregation of alpha-synuclein.Lrrk2 R1441G-related Parkinson's disease: evidence of a common founding event in the seventh century in Northern SpainLack of evidence for an association between UCHL1 S18Y and Parkinson's disease.Cellular stress responses: cell survival and cell deathEtiology and pathophysiology of frontotemporal dementia, Parkinson disease and Alzheimer disease: lessons from genetic studies.Histamine N-methyltransferase Thr105Ile is not associated with Parkinson's disease or essential tremor.
P2860
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P2860
Genetics of Parkinson disease: paradigm shifts and future prospects.
description
2006 nî lūn-bûn
@nan
2006年の論文
@ja
2006年学术文章
@wuu
2006年学术文章
@zh-cn
2006年学术文章
@zh-hans
2006年学术文章
@zh-my
2006年学术文章
@zh-sg
2006年學術文章
@yue
2006年學術文章
@zh
2006年學術文章
@zh-hant
name
Genetics of Parkinson disease: paradigm shifts and future prospects.
@ast
Genetics of Parkinson disease: paradigm shifts and future prospects.
@en
type
label
Genetics of Parkinson disease: paradigm shifts and future prospects.
@ast
Genetics of Parkinson disease: paradigm shifts and future prospects.
@en
prefLabel
Genetics of Parkinson disease: paradigm shifts and future prospects.
@ast
Genetics of Parkinson disease: paradigm shifts and future prospects.
@en
P2860
P356
P1476
Genetics of Parkinson disease: paradigm shifts and future prospects
@en
P2093
Matthew James Farrer
P2860
P2888
P304
P356
10.1038/NRG1831
P577
2006-04-01T00:00:00Z