Emerging roles of DP and CRTH2 in allergic inflammation.
about
ANKRD13C acts as a molecular chaperone for G protein-coupled receptorsPGH1, the precursor for the anti-inflammatory prostaglandins of the 1-series, is a potent activator of the pro-inflammatory receptor CRTH2/DP2Prostanoid receptor antagonists: development strategies and therapeutic applicationsExpression of DP2 (CRTh2), a prostaglandin D₂ receptor, in human mast cells.Single- and multiple-dose tolerability and pharmacokinetics of the CRTH2 antagonist setipiprant in healthy male subjects.Pharmacokinetics, Safety, and Tolerability of Fevipiprant (QAW039), a Novel CRTh2 Receptor Antagonist: Results From 2 Randomized, Phase 1, Placebo-Controlled Studies in Healthy Volunteers.Chitin particles induce size-dependent but carbohydrate-independent innate eosinophiliaMechanistic systems biology of inflammatory gene expression in airway smooth muscle as tool for asthma drug development.Prostagladin D2 is a mast cell-derived antiangiogenic factor in lung carcinomaActivation of the D prostanoid 1 receptor suppresses asthma by modulation of lung dendritic cell function and induction of regulatory T cellsGeneration and characterization of an antagonistic monoclonal antibody against an extracellular domain of mouse DP2 (CRTH2/GPR44) receptors for prostaglandin D2.Anti-inflammatory role of PGD2 in acute lung inflammation and therapeutic application of its signal enhancement.Prostaglandin D(2) in inflammatory arthritis and its relation with synovial fluid dendritic cells.The roles of the prostaglandin D(2) receptors DP(1) and CRTH2 in promoting allergic responsesRole of prostaglandin D2 receptor DP as a suppressor of tumor hyperpermeability and angiogenesis in vivo.The mast cell and allergic diseases: role in pathogenesis and implications for therapy.In vitro allergen challenge of peripheral blood induces differential gene expression in mononuclear cells of asthmatic patients: inhibition of cytosolic phospholipase A2alpha overcomes the asthma-associated response.Cyclooxygenase-2 in newborn hyperoxic lung injuryMicrosomal prostaglandin E synthase-1 inhibition in cardiovascular inflammatory disease.Prostaglandins in pathogenesis and treatment of multiple sclerosis.Efficacy and safety of setipiprant in seasonal allergic rhinitis: results from Phase 2 and Phase 3 randomized, double-blind, placebo- and active-referenced studies.Novel CRTH2 antagonists: a review of patents from 2006 to 2009.Lipid-cytokine-chemokine cascades orchestrate leukocyte recruitment in inflammationRole of phospholipase A2s and lipid mediators in secondary damage after spinal cord injury.Identification of a prostaglandin D2 metabolite as a neuritogenesis enhancer targeting the TRPV1 ion channel.Targeting the PGD2/CRTH2/DP1 Signaling Pathway in Asthma and Allergic Disease: Current Status and Future Perspectives.A randomized controlled phase II clinical trial comparing ONO-4053, a novel DP1 antagonist, with a leukotriene receptor antagonist pranlukast in patients with seasonal allergic rhinitis.Discovery of anti-inflammatory role of prostaglandin D2.Optimization of the Central Core of Indolinone-Acetic Acid-Based CRTH2 (DP2) Receptor Antagonists.The C-terminal tail of CRTH2 is a key molecular determinant that constrains Galphai and downstream signaling cascade activation.Mast cell-derived prostaglandin D2 controls hyaluronan synthesis in human orbital fibroblasts via DP1 activation: implications for thyroid eye disease.Prostaglandins and Their Receptors in Eosinophil Function and As Therapeutic Targets.Pharmacokinetic interactions between simvastatin and setipiprant, a CRTH2 antagonist.Co-operative signalling through DP(1) and DP(2) prostanoid receptors is required to enhance leukotriene C(4) synthesis induced by prostaglandin D(2) in eosinophils.Eosinophils Contribute to Intestinal Inflammation via Chemoattractant Receptor-homologous Molecule Expressed on Th2 Cells, CRTH2, in Experimental Crohn's Disease.Disposition and metabolism of setipiprant, a selective oral CRTH2 antagonist, in humans.Expression and detrimental role of hematopoietic prostaglandin D synthase in spinal cord contusion injury.Interferon Potentiates Toll-Like Receptor-Induced Prostaglandin D2 Production through Positive Feedback Regulation between Signal Transducer and Activators of Transcription 1 and Reactive Oxygen Species.Prostaglandin D2 metabolite in urine is an index of food allergy.Niacin Promotes Cardiac Healing after Myocardial Infarction through Activation of the Myeloid Prostaglandin D2 Receptor Subtype 1.
P2860
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P2860
Emerging roles of DP and CRTH2 in allergic inflammation.
description
2006 nî lūn-bûn
@nan
2006年の論文
@ja
2006年学术文章
@wuu
2006年学术文章
@zh-cn
2006年学术文章
@zh-hans
2006年学术文章
@zh-my
2006年学术文章
@zh-sg
2006年學術文章
@yue
2006年學術文章
@zh
2006年學術文章
@zh-hant
name
Emerging roles of DP and CRTH2 in allergic inflammation.
@ast
Emerging roles of DP and CRTH2 in allergic inflammation.
@en
type
label
Emerging roles of DP and CRTH2 in allergic inflammation.
@ast
Emerging roles of DP and CRTH2 in allergic inflammation.
@en
prefLabel
Emerging roles of DP and CRTH2 in allergic inflammation.
@ast
Emerging roles of DP and CRTH2 in allergic inflammation.
@en
P1476
Emerging roles of DP and CRTH2 in allergic inflammation.
@en
P2093
Evi Kostenis
Trond Ulven
P304
P356
10.1016/J.MOLMED.2006.02.005
P577
2006-03-20T00:00:00Z