High-Affinity Interaction of the K-Ras4B Hypervariable Region with the Ras Active Site.
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Inhibitors of Ras-SOS Interactions.The RAS-Effector Interface: Isoform-Specific Differences in the Effector Binding RegionsGTP Binding and Oncogenic Mutations May Attenuate Hypervariable Region (HVR)-Catalytic Domain Interactions in Small GTPase K-Ras4B, Exposing the Effector Binding Site.The Structural Basis of Oncogenic Mutations G12, G13 and Q61 in Small GTPase K-Ras4B.The disordered hypervariable region and the folded catalytic domain of oncogenic K-Ras4B partner in phospholipid binding.The higher level of complexity of K-Ras4B activation at the membrane.Modeling of RAS complexes supports roles in cancer for less studied partners.Flexible-body motions of calmodulin and the farnesylated hypervariable region yield a high-affinity interaction enabling K-Ras4B membrane extraction.K-Ras4B/calmodulin/PI3Kα: A promising new adenocarcinoma-specific drug target?Calmodulin and PI3K Signaling in KRAS Cancers.Drugging Ras GTPase: a comprehensive mechanistic and signaling structural view.A New View of Pathway-Driven Drug Resistance in Tumor Proliferation.Intrinsic protein disorder in oncogenic KRAS signaling.Disordered Regions Flanking Ordered Domains Modulate Signaling TransductionMultiplexed in vivo homology-directed repair and tumor barcoding enables parallel quantification of Kras variant oncogenicity.The dynamic mechanism of RASSF5 and MST kinase activation by Ras.Structural basis for intramolecular interaction of post-translationally modified H-Ras•GTP prepared by protein ligation.Assessment of mutation probabilities of KRAS G12 missense mutants and their long-timescale dynamics by atomistic molecular simulations and Markov state modeling
P2860
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P2860
High-Affinity Interaction of the K-Ras4B Hypervariable Region with the Ras Active Site.
description
2015 nî lūn-bûn
@nan
2015年の論文
@ja
2015年学术文章
@wuu
2015年学术文章
@zh-cn
2015年学术文章
@zh-hans
2015年学术文章
@zh-my
2015年学术文章
@zh-sg
2015年學術文章
@yue
2015年學術文章
@zh
2015年學術文章
@zh-hant
name
High-Affinity Interaction of the K-Ras4B Hypervariable Region with the Ras Active Site.
@ast
High-Affinity Interaction of the K-Ras4B Hypervariable Region with the Ras Active Site.
@en
type
label
High-Affinity Interaction of the K-Ras4B Hypervariable Region with the Ras Active Site.
@ast
High-Affinity Interaction of the K-Ras4B Hypervariable Region with the Ras Active Site.
@en
prefLabel
High-Affinity Interaction of the K-Ras4B Hypervariable Region with the Ras Active Site.
@ast
High-Affinity Interaction of the K-Ras4B Hypervariable Region with the Ras Active Site.
@en
P2093
P2860
P1433
P1476
High-Affinity Interaction of the K-Ras4B Hypervariable Region with the Ras Active Site.
@en
P2093
Avik Banerjee
Benjamin C Freed
Hyunbum Jang
Liv Johannessen
Lyuba Khavrutskii
Nadya I Tarasova
Sergey G Tarasov
Sherwin J Abraham
Tanmay S Chavan
Vadim Gaponenko
P2860
P304
P356
10.1016/J.BPJ.2015.09.034
P407
P577
2015-12-01T00:00:00Z