High-Affinity Interaction of the K-Ras4B Hypervariable Region with the Ras Active Site. - Wikidata - wikimedia - TriplyDB

High-Affinity Interaction of the K-Ras4B Hypervariable Region with the Ras Active Site.

High-Affinity Interaction of the K-Ras4B Hypervariable Region with the Ras Active Site.

http://www.wikidata.org/entity/Q36426356

about

Inhibitors of Ras-SOS Interactions.The RAS-Effector Interface: Isoform-Specific Differences in the Effector Binding Regions GTP Binding and Oncogenic Mutations May Attenuate Hypervariable Region (HVR)-Catalytic Domain Interactions in Small GTPase K-Ras4B, Exposing the Effector Binding Site.The Structural Basis of Oncogenic Mutations G12, G13 and Q61 in Small GTPase K-Ras4B.The disordered hypervariable region and the folded catalytic domain of oncogenic K-Ras4B partner in phospholipid binding.The higher level of complexity of K-Ras4B activation at the membrane.Modeling of RAS complexes supports roles in cancer for less studied partners.Flexible-body motions of calmodulin and the farnesylated hypervariable region yield a high-affinity interaction enabling K-Ras4B membrane extraction.K-Ras4B/calmodulin/PI3Kα: A promising new adenocarcinoma-specific drug target?Calmodulin and PI3K Signaling in KRAS Cancers.Drugging Ras GTPase: a comprehensive mechanistic and signaling structural view.A New View of Pathway-Driven Drug Resistance in Tumor Proliferation.Intrinsic protein disorder in oncogenic KRAS signaling.Disordered Regions Flanking Ordered Domains Modulate Signaling Transduction Multiplexed in vivo homology-directed repair and tumor barcoding enables parallel quantification of Kras variant oncogenicity.The dynamic mechanism of RASSF5 and MST kinase activation by Ras.Structural basis for intramolecular interaction of post-translationally modified H-Ras•GTP prepared by protein ligation.Assessment of mutation probabilities of KRAS G12 missense mutants and their long-timescale dynamics by atomistic molecular simulations and Markov state modeling

P2860

Q35859222-9873C76B-AA1C-4BBC-83F2-A0DFDDE519E3 Q36217950-D8D92FA6-1B3D-4826-B41F-A4052E6F4B87 Q36323471-469C5728-83BF-4AD1-82A7-B19ADAB79063 Q36606151-1B9036A1-C6AF-4C03-B1CD-127CEC4D077B Q36669604-82C384BE-CD91-4844-803C-AAC02D600D93 Q36705290-8BE58AD5-72E7-4D8E-954C-4FFF1EFAACF8 Q38641385-2CDDABEB-6263-458B-B39D-6B2A0F4320B8 Q38721757-76ACAF62-C400-4100-B479-140443E5DC0E Q38731776-4D0FCA1D-E736-4E5D-865F-F17D4E06E7E4 Q38809850-940CB6B3-FB15-4413-9802-E2B500B1F6AD Q38891257-41BCFC26-9FDC-44EA-B918-85DA43895F32 Q39155018-A5D25C38-8831-446E-AB83-7B9689EE322E Q39361391-7BB4C0BF-2891-4B15-B784-BDE22C4A7153 Q41275884-4847206A-68EC-40F9-A81D-B83467B43D5D Q47141518-1E0B219B-6964-43B6-85BD-978F2AF9B51A Q47566645-2EA6FB83-6EFF-43C2-A557-BDF03A742B06 Q47899100-8885FDFD-86CF-4E1B-B29A-C742F38DDDDD Q58753858-993CCDC5-B43F-40F4-8638-3A2D34547150

P2860

High-Affinity Interaction of the K-Ras4B Hypervariable Region with the Ras Active Site.

http://www.wikidata.org/entity/Q36426356

description

2015 nî lūn-bûn

@nan

2015年の論文

@ja

2015年学术文章

@wuu

2015年学术文章

@zh-cn

2015年学术文章

@zh-hans

2015年学术文章

@zh-my

2015年学术文章

@zh-sg

2015年學術文章

@yue

2015年學術文章

@zh

2015年學術文章

@zh-hant

name

High-Affinity Interaction of the K-Ras4B Hypervariable Region with the Ras Active Site.

@ast

High-Affinity Interaction of the K-Ras4B Hypervariable Region with the Ras Active Site.

@en

type

label

High-Affinity Interaction of the K-Ras4B Hypervariable Region with the Ras Active Site.

@ast

High-Affinity Interaction of the K-Ras4B Hypervariable Region with the Ras Active Site.

@en

prefLabel

High-Affinity Interaction of the K-Ras4B Hypervariable Region with the Ras Active Site.

@ast

High-Affinity Interaction of the K-Ras4B Hypervariable Region with the Ras Active Site.

@en

P1433

Q36426356-A1621557-943E-48CF-B731-B10F224033DA

P1476

Q36426356-127BF46D-CD1A-4686-BBEF-500438E40371

P2093

Q36426356-1346E761-F325-4269-AE90-1EDDD318D507

Q36426356-42585107-8FAA-4093-BF7C-4ABD8FE16A75

Q36426356-48C35C06-6DFB-48FF-BFD7-4ACBEB8FAA79

Q36426356-53DD424A-F44B-48AB-926A-9D348EB7D79B

Q36426356-6ECAB5A1-0B70-4E55-BBF6-2A055E7C31E6

Q36426356-6EFC2072-DE3E-4AB9-A04E-AAACB7DA6F4A

Q36426356-E61872DF-A8E5-415F-8A40-7A2AC65747F1

Q36426356-EE707E0C-EA4B-43C4-931E-4A07C4E9774B

Q36426356-FDBF3452-C882-45B8-A3E8-067DCD414A73

Q36426356-FDD66F34-10B5-4218-95FC-3B4F1132B6D5

P2860

Q36426356-028D0806-1ED5-49C3-AC0F-F64600F57EF5

Q36426356-05739ACC-A6A2-4DE7-BD0A-CF08C9DC7A9E

Q36426356-08BAE9C6-041A-46F7-897B-FAE58C8F4EB8

Q36426356-0BE68852-7139-475B-98F1-A15637733EE7

Q36426356-106B69B9-DDEA-4AC0-B217-384C7EA15E0B

Q36426356-15AD3D92-314F-4972-96D3-357F492D912E

Q36426356-1B4E4D64-5284-46FD-A794-FB6AB9461E3F

Q36426356-1EBDD10A-D315-43BD-AA28-B179F8F066D7

Q36426356-23606407-1BB4-4400-B2D3-E1AB1E2571A4

Q36426356-23E03902-5EC5-4EA2-A352-D5D7B2C53DFB

P304

Q36426356-DCE5CC9D-B74A-49E1-A1C3-62F9F3EBA98A

P31

Q36426356-F36DDB3E-181E-45DD-9461-8EBA9A4E7A05

P356

Q36426356-C5EF620A-07E7-4260-B43A-981BB8F228BF

P407

Q36426356-CEF100A6-F876-4B9C-B9AB-A5CAD804A003

P433

Q36426356-C0C4E1F7-5CCA-4ED1-9A35-F637161CB9DC

P478

Q36426356-FB83A5FD-7EC0-4DE0-96E1-202CC7012E49

P50

Q36426356-DE751611-2B08-4089-9140-A3CCD7BE1D21

P577

Q36426356-00046CAC-F4D4-4E83-BE79-53FCF5BBFA44

P698

Q36426356-9C8DD9FE-607D-4CF8-B41A-0815895CBF3B

P932

Q36426356-D06B6C09-EE80-437A-9CF5-EEFF9179D023

P356

J.BPJ.2015.09.034

P1433

Biophysical Journal

P1476

High-Affinity Interaction of the K-Ras4B Hypervariable Region with the Ras Active Site.

@en

P2093

Avik Banerjee

http://www.w3.org/2001/XMLSchema#string

Benjamin C Freed

http://www.w3.org/2001/XMLSchema#string

Hyunbum Jang

http://www.w3.org/2001/XMLSchema#string

Liv Johannessen

http://www.w3.org/2001/XMLSchema#string

Lyuba Khavrutskii

http://www.w3.org/2001/XMLSchema#string

Nadya I Tarasova

http://www.w3.org/2001/XMLSchema#string

Sergey G Tarasov

http://www.w3.org/2001/XMLSchema#string

Sherwin J Abraham

http://www.w3.org/2001/XMLSchema#string

Tanmay S Chavan

http://www.w3.org/2001/XMLSchema#string

Vadim Gaponenko

http://www.w3.org/2001/XMLSchema#string

P2860

The Ras-RasGAP complex: structural basis for GTPase activation and its loss in oncogenic Ras mutants

A comprehensive catalogue of somatic mutations from a human cancer genome

Solution structure and backbone dynamics of the second PDZ domain of postsynaptic density-95

Small-molecule ligands bind to a distinct pocket in Ras and inhibit SOS-mediated nucleotide exchange activity

Discovery of Small Molecules that Bind to K-Ras and Inhibit Sos-Mediated Activation

K-Ras(G12C) inhibitors allosterically control GTP affinity and effector interactions

Molecular switch for signal transduction: structural differences between active and inactive forms of protooncogenic ras proteins

VMD: visual molecular dynamics

Scalable molecular dynamics with NAMD

NMRPipe: a multidimensional spectral processing system based on UNIX pipes

P304

2602-2613

http://www.w3.org/2001/XMLSchema#string

P31

scholarly article

P356

10.1016/J.BPJ.2015.09.034

http://www.w3.org/2001/XMLSchema#string

P407

P433

12

http://www.w3.org/2001/XMLSchema#string

P478

109

http://www.w3.org/2001/XMLSchema#string

P50

P577

2015-12-01T00:00:00Z

http://www.w3.org/2001/XMLSchema#dateTime

P698

26682817

http://www.w3.org/2001/XMLSchema#string

P932

4699860

http://www.w3.org/2001/XMLSchema#string